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Submitted
19 August 2022
Accepted
5 October 2022
Published
5 December 2022
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Abstract

Highlights :



  1. Alternative medicine is needed for pityriasis versicolor because there are recurrence cases and resistance to antifungal agents.

  2. Kinar leaf ethanol extract cannot inhibit the growth of Malassezia furfur.

  3. Further studies are suggested on the type of solvent and appropriate concentration to attract more bioactive compounds.


Abstract :


Pityriasis versicolor is a superficial dermatomycosis that can decrease human self-confidence. This infection is caused by the fungus Malassezia furfur. Eighty percent of recurrence cases after treatment and resistance to antifungal agents were found. Therefore, alternative medicine is needed. Kinar (Kleinhovia hospita Linn.) is a tropical plant that have bioactive compounds, such as alkaloids, flavonoids, tannins, and saponins. The purpose of this study was to determine the effectiveness of kinar leaf extract against the growth of Malassezia furfur. This research was a laboratory experimental study using paper disc diffusion method. Kinar leaves (green and yellow leaves) were macerated using 96% ethanol and made into concentrations of 10%, 20%, 40%, 60%, 80%, and 100%. As much as 200 mg of ketoconazole was used as a positive control and distilled water as a negative control then tested on Malassezia furfur using Sabouraud dextrose agar (SDA). The parameter observed was the clear zone formed around the paper disc. The tests and observations showed that there was a clear zone formed around the paper disc. It means that the kinar leaf extract cannot inhibit the growth of Malassezia furfur.

Keywords

Antifungal Kleinhovia hospita L. Malassezia furfur tropical disease human and medicine

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How to Cite
Muhammad Zaid Wakano, Astuty, E., & Amanda Gracia Manuputty. (2022). Antifungal Activity of Kinar (Kleinhovia hospita L.) Leaf Ethanol Extract Against Malassezia furfur. Folia Medica Indonesiana, 58(4), 343–347. https://doi.org/10.20473/fmi.v58i4.38387
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References

  1. Allen H, Goyal K, Ogrich L (2015). Biofilm formation by Malassezia furfur/ovale as a possible mechanism of pathogenesis in tinea versicolor. J Clin Exp Dermatol Res 06, 2–6.
  2. Araya S, Abuye M, Negesso AE (2021). Epidemiological characterization of dermatomycosis in Ethiopia. Clin Cosmet Investig Dermatol 14, 83–9.
  3. Ariana D (2018). Perbedaan zona hambat terhadap jamur Malassezia furfur antara pemberian ekstrak umbi bawang putih (Allium sativum Linn) dengan ekstrak kulit umbi bawang putih (Allium sativum Linn). J Muhammadiyah Med Lab Technol 1, 77–87.
  4. Azis T, Febrizky S, Mario AD (2014). Pengaruh jenis pelarut terhadap persen yieldalkaloiddari daun salam India (Murraya koenigii). Tek Kim 20, 1–6.
  5. Dirga A, Rahman IW, Yunasdy M (2022). Uji daya hambat daun ketepeng cina terhadap pertumbuhan Malassezia furfur penyebab tinea versicolor. J-HEST J Heal Educ Econ Sci Technol 3, 96–9.
  6. Gaffar I, Mamahit LP (2010). Satu senyawa steroid dari kulit batang tumbuhan paliasa (Kleinhovia hospita L.) asal Sulawesi Selatan. Chem Prog 3, 24–8.
  7. Gupta A, Bluhm R, Summerbell R (2002). Pityriasis versicolor. J Eur Acad Dermatology Venereol 16, 19–33.
  8. Gupta A, Foley K (2015). Antifungal treatment for pityriasis versicolor. J Fungi 1, 13–29.
  9. Hasanuddin S, Andini C (2017). Uji aktivitas antiradikal bebas ekstrak daun paliasa (Kleinhovia hospita Linn.). J Mandala Pharmacon Indones 3, 119–26.
  10. Isa DY, Niode NJ, Pandaleke HE (2016). Profil pitiriasis versikolor di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Desember 2013. e-CliniC 4, 2–6.
  11. Kalyani M, Bhuvaneshwari G, As SB (2014). Characterization and in-vitro susceptibility of malassezia species in pityriasis versicolar cases from a tertiary care centre. Res J Pharm , Biol Chem Sci 5, 4–7.
  12. Kang S, Masayuki A, Bruckner AL, et al (2019). Fitzpatrick’s dermatology, 9th edn. McGraw-Hill Education, New York.
  13. Kulkarni M, Hastak V, Jadhav V, et al (2020). Fenugreek leaf extract and its gel formulation show activity against Malassezia furfur. Assay Drug Dev Technol 18, 45–55.
  14. Kusuma IJ Di, Prasetyorini, Wardatun S (2018). Toksisitas ekstrak daun kenikir (Cosmos caudatus Kunth) dengan perbedaan metode dan jenis pelarut berbeda. J Online Mhs 1, 1–9.
  15. Kyriakidis I, Tragiannidis A, Munchen S, et al (2016). Clinical hepatotoxicity associated with antifungal agents. Expert Opin Drug Saf 16, 1–17.
  16. Mahmoud YA, Metwally MA, Mubarak HH, et al (2014). Treatment of tinea versicolor caused by malassezia furfur with dill seed extract: an experimental study. Int J Pharm Pharm Sci 7, 3–7.
  17. Prohic A, Jovovic Sadikovic T, Krupalija-Fazlic M, et al (2016). Malassezia species in healthy skin and in dermatological conditions. Int J Dermatol 55, 494–504.
  18. Radila W (2022). Hubungan personal hygiene individu dengan kejadian pityriasis versicolor. J Med Hutama 03, 1758–63.
  19. Rosida F, Ervianti E (2017). Retrospective Study: Superficial Mycoses (Penelitian retrospektif: Mikosis superfisialis). Berk Ilmu Kesehat Kulit dan Kelamin – Period Dermatology Venereol 29, 121–4.
  20. Sanjaya W, Rialita A, Mahyarudin M (2021). Aktivitas Antijamur Ekstrak Etanol Daun Cengkodok (Melastoma malabathricum) Terhadap Pertumbuhan Malassezia furfur. J Fitofarmaka Indones 8, 23–32.
  21. Sears D, Schwartz BS (2017). Candida auris : An emerging multidrug-resistant pathogen. Int J Infect Dis 63, 95–8.
  22. Sheiladji MU, Zulkarnain I (2016). Profil mikosis superfisialis pada pasien dermatologi anak. Berk Ilmu Kesehat Kulit dan Kelamin – Period Dermatology Venereol 28, 9–11.
  23. Shibata N, Saitoh T, Tadokoro Y, et al (2009). The cell wall galactomannan antigen from Malassezia furfur and Malassezia pachydermatis contains β-1,6-linked linear galactofuranosyl residues and its detection has diagnostic potential. Microbiology 155, 3420–9.
  24. Sivasankar C, Gayathri S, Bhaskar JP, et al (2017). Evaluation of selected Indian medicinal plants for antagonistic potential against Malassezia spp. and the synergistic effect of embelin in combination with ketoconazole. Microb Pathog 110, 66–72.
  25. Stalhberger T, Simenel C, Clavaud C, et al (2014). Chemical organization of the cell wall polysaccharide core of Malassezia restricta. J Biol Chem 289, 12647–56.
  26. Stevani E, Setyaningsih Y, Harfiani E (2021). Uji efektivitas ekstrak daun kenikir (Cosmos caudatus Kunth) terhadap penghambatan pertumbuhan jamur Malassezia furfur. In Prosiding Seminar Nasional Riset Kedokteran (Sensorik 2022).
  27. Triana O, Prasetya F, Kuncoro H, et al (2016). Aktivitas antijamur ekstrak daun ketepeng cina (Cassia alata L.). J Sains dan Kesehat 1, 311–5.
  28. Valli M, Pivatto M, Danuello A, et al (2012). Tropical biodiversity: Has it been a potential source of secondary metabolites useful for medicinal chemistry? Quim Nova 35, 2278–87.
  29. Vleminckx J, Salazar D, Fortunel C, et al (2018). Divergent secondary metabolites and habitat filtering both contribute to tree species coexistence in the Peruvian Amazon. Front Plant Sci 9, 5–10.
  30. World Health Organization (2005). Epidemiology and management of common skin diseases in children in developing countries. Available at: https://apps.who.int/iris/handle/10665/69229.
  31. Yunus R, Malik N (2019). Uji bioaktivitas ekstrak daun tawa ndokulo (Kleinnhovia hospita Linn) terhadap bakteri enteropatogenik. J Endur 4, 70.
  32. Yusuf AL, Nurawaliah E, Harun N (2017). Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur. Kartika J Ilm Farm 5, 62.