Article Sidebar

Submitted
21 October 2022
Accepted
3 August 2023
Published
10 June 2023
Download
PDF
Statistic
Read Counter : 804 Download : 215

Main Article Content

Abstract

Highlights :



  1. Cabbage extract application accelerates wound healing and has anti-inflammatory effect.

  2. Cabbage extract serves as an affordable source material for wound healing and anti-inflammation.


Abstract


Cabbage is a widely consumed vegetable known for its health benefits due to its rich nutrients and phytochemicals, especially phenolic compounds, which are known to have potent anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of cabbage extract on wound healing by observing inflammatory responses in wound tissue. A total of 24 male rats were divided into four groups, with six rats in each group. The experiment was conducted for five days by administering cabbage extract to the treatment group and distilled water to the control group. Skin wound tissues were collected from all rats for histological observation by counting the number of macrophages and blood vessels. The results of the observation were analyzed statistically using an independent sample t-test with p<0.05. The results showed that the number of macrophages and blood vessels in the treatment group was significantly higher than the control group on the third day and significantly lower on the fifth day. In conclusion, the administration of cabbage extract can accelerate the inflammatory and proliferative phases of wound healing by promoting the migration of cells, including macrophages, resulting in accelerated angiogenesis. In addition, the decreased number of macrophages and blood vessels during the proliferative phase showed that the healing phase had reached a more advanced stage. 

Keywords

Healthy lifestyle anti-inflammation cabbage extract wound healing

Article Details

License

Copyright (c) 2023 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Nidya Ulfana Tsania, Willy Sandhika, & Sawitri. (2023). The Effect of Cabbage (Brassica oleracea var. capitata L.) Extract on Macrophage and Blood Vessel Counts in Clean Wound Tissue of Male Rats (Rattus norvegicus). Folia Medica Indonesiana, 59(2), 136–142. https://doi.org/10.20473/fmi.v59i2.39922
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Abdurrahmat AS (2014). Luka, peradangan dan pemulihan. Jurnal Entropi 9, 729–738. Available at: https://repository.ung.ac.id/karyailmiah/show/ 468/luka-peradangan-dan-pemulihan.html
  2. Bhuana HS, Sritamin M, Wirawan IGP (2021). Studi komparasi jenis pelarut ekstraksi terhadap kandungan fitokimia daun tanaman kubis ungu. Nandur. Available at: https://ojs.unud.ac.id/ index.php/nandur/article/view/79047.
  3. Cañedo-Dorantes L, Cañedo-Ayala M (2019). Skin acute wound healing: A comprehensive review. Int International Journal of Inflammation 2019, 1–15. doi: 10.1155/2019/3706315.
  4. Chhabra S, Chhabra N, Kaur A, et al (2017). Wound healing concepts in clinical practice of OMFS. Journal of Maxillofacial and Oral Surgery 16, 403–423. doi: 10.1007/s12663-016-0880-z.
  5. Ekor M (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology. doi: 10.3389/fphar.2013.00177.
  6. Gonzalez AC de O, Costa TF, Andrade Z de A, et al (2016). Wound healing - A literature review. A Anais Brasileiros de Dermatologia 91, 614–620. doi: 10.1590/abd1806-4841.20164741.
  7. Gunawan F, Sandhika W, Wiqoyah N (2021). Effectiveness of black honey as an antiinflammatory substance in rat's wound infected by Staphylococcus aureus. Berkala Ilmu Kesehatan Kulit dan Kelamin 33, 13. doi: 10.20473/bikk.V33.1.2021.13-18.
  8. Kim MR, Kim TI, Choi BR, et al (2020). Brassica oleracea prevents HCl/ethanol-induced gastric damages in mice. Applied Sciences 11, 16. doi: 10.3390/app11010016.
  9. Krzyszczyk P, Schloss R, Palmer A, et al (2018). The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes. Frontiers in Physiology. doi: 10.3389/fphys.2018.00419.
  10. Kurniawati EM, Santoso B, Rantam FA, et al (2022). Does freeze dried amnion useful as scaffold for mesenchymal stem cell for repair of vesicovaginal fistula? An overview of proliferative and remodeling phase in the wound healing process. European Journal of Obstetrics & Gynecology and Reproductive Biology 274, 113–116. doi: 10.1016/j.ejogrb.2022.05.017.
  11. Landén NX, Li D, Ståhle M (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences 73, 3861–3885. doi: 10.1007/s00018-016-2268-0.
  12. Lee YY, Saba E, Kim M, et al (2018). Antioxidant and anti-inflammatory properties of raw and processed fruits and vegetables. Biomedical Science Letters 24, 196–205. doi: 10.15616/BSL.2018.24.3.196.
  13. Panche AN, Diwan AD, Chandra SR (2016). Flavonoids: an overview. Journal of Nutritional Science 5, e47. doi: 10.1017/jns.2016.41.
  14. Park S, Arasu MV, Jiang N, et al. (2014). Metabolite profiling of phenolics, anthocyanins and flavonols in cabbage (Brassica oleracea var. capitata). Industrial Crops and Products 60, 8–14. doi: 10.1016/j.indcrop.2014.05.037.
  15. Rosique RG, Rosique MJ, Farina Junior JA (2015). Curbing inflammation in skin wound healing: A review. International Journal of Inflammation 2015, 1–9. doi: 10.1155/2015/316235.
  16. Ryou SH, Cho IJ, Choi B-R, et al (2021). Brassica oleracea var. capitata L. alleviates indomethacin-induced acute gastric injury by enhancing anti-inflammatory and antioxidant activity. Processes 9, 372. doi: 10.3390/pr9020372.
  17. Sadikim RY, Sandhika W, Saputro ID (2018). Pengaruh pemberian ekstrak jahe merah (Zingiber officinale var. rubrum) terhadap jumlah sel makrofag dan pembuluh darah pada luka bersih mencit (Mus musculus) Jantan (Penelitian Eksperimental pada Hewan Coba). Berkala Ilmu Kesehatan Kulit dan Kelamin 30, 121–127. doi: https://doi.org/10.20473/bikk.V30.2.2018.121-127.
  18. Sanlier N, Guler Saban M (2018). The benefits of brassica vegetables in human health. Journal of Human Health Research. Available at: https://article.scholarena.co/The-Benefits-of-Brassica-Vegetables-on-Human-Health.pdf.
  19. Sarandy MM, Novaes RD, da Matta SLP, et al (2015). Ointment of Brassica oleracea var. capitata matures the extracellular matrix in skin wounds of wistar rats. Evidence-Based Complementary and Alternative Medicine 2015, 1–9. doi: 10.1155/2015/919342.
  20. Serra MB, Barroso WA, Silva NN da, et al (2017). From inflammation to current and alternative therapies involved in wound healing. International Journal of Inflammation 2017, 1–17. doi: 10.1155/2017/3406215.
  21. Shook B, Xiao E, Kumamoto Y, et al (2016). CD301b+ macrophages are essential for effective skin wound healing. Journal of Investigative Dermatology 136, 1885–1891. doi: 10.1016/j.jid.2016.05.107.
  22. Šitum M, Kolić M, Redžepi G, et al. (2014). Kronicne rane kao javnozdravstveni problem. Acta medica Croatica . Available at: https://hrcak.srce.hr/127814.
  23. Sumayyah S, Salsabila N (2017). Obat tradisional : Antara khasiat dan efek sampingnya. Farmasetika.com (Online) 2, 1. doi: 10.24198/farmasetika.v2i5.16780.
  24. Tilg H (2015). Cruciferous vegetables: prototypic anti-inflammatory food components. Clinical Phytoscience 1, 10. doi: 10.1186/s40816-015-0011-2.
  25. Torregrossa M, Kakpenova A, Simon JC, et al (2021). Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds. Biological Chemistry 402, 1289–1307. doi: 10.1515/hsz-2021-0145.
  26. Uuh"Narvaez JJ, Segura"Campos MR (2021). Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management. Journal of Food Science 86, 4775–4798. doi: 10.1111/1750-3841.15939.
  27. Wang N, Wu Y, Zeng N, et al (2016). E2F1 hinders skin wound healing by repressing vascular endothelial growth factor (VEGF) expression, neovascularization, and macrophage recruitment ed. Wary KK. PLoS One 11, e0160411. doi: 10.1371/journal.pone.0160411.
  28. Winarni D, Husna FN, Syadzha MF, et al (2022). Topical administration effect of Sargassum duplicatum and Garcinia mangostana extracts combination on open wound healing process in diabetic mice ed. Brun P. Scientifica (Cairo) 2022, 1–7. doi: 10.1155/2022/9700794.