Main Article Content

Abstract

Highlights:


1. Uncertainty regarding the association between hypertension and the levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) signifies the need for more research, particularly in the realm of sex-specific analysis.
2. Our study uncovered significant associations between hypertension and the levels of total cholesterol and triglycerides, expanding our understanding of the impact of lipid profiles on hypertension.
3. This research may potentially pave the way for personalized diagnostic and therapeutic strategies, ultimately enhancing hypertension management and patient outcomes. 


 


Abstract


Hypertension is one of the most frequent non-communicable diseases and a risk factor for cardiovascular disease, contributing to most deaths globally. The risk of hypertension is higher in those with uncontrolled lipids. In this study, the incidence of hypertension and lipid profiles were examined from March 2020 to March 2022. The aim of this study was to determine the relationship between hypertension in men aged 45–60 years and their lipid profiles, which include total cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). This study used an analytical observational design with a cross-sectional approach. Medical records were utilized as secondary data. Statistical analysis was conducted using the Spearman rank correlation test. Statistical significance was determined at p<0.05. This research examined 115 patients with hypertension. The results showed that the stage of hypertension was correlated with total cholesterol (r=0.317; p=0.001) and triglyceride levels (r=0.217; p=0.02). However, the stage of hypertension was not significantly correlated with LDL (r=0.158; p=0.91) and HDL (r=0.75; p=0.423). Hence, this current study underscores the nuanced relationship between lipid profiles and the stage of hypertension in middle-aged male patients. This study highlights the importance of sex-specific analysis in hypertensive research. It also provides promising avenues for further investigation. 

Keywords

cardiovascular disease hypertension triglyceride LDL HDL

Article Details

Author Biography

Sulistiawati, Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

How to Cite
Arin Nurtya, Artaria Tjempakasari, Ummi Maimunah, Sulistiawati, & I Made Subhawa Harsa. (2023). Hypertension and Lipid Profiles in Middle-Aged Male Patients: A Study at a Tertiary Hospital in Surabaya, Indonesia. Folia Medica Indonesiana, 59(4), 321–328. https://doi.org/10.20473/fmi.v59i4.49674

References

  1. Aslam M (2020). Introducing Kolmogorov-Smirnov tests under uncertainty: An application to radioactive data. ACS Omega 5, 914–917. doi: 10.1021/acsomega.9b03940.
  2. Astana PRW, Triyono A (2018). Gambaran profil lipid pada pasien hipertensi di Klinik Saintifikasi Jamu Hortus Medicus Tawamangu. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal). Available at: https://docplayer.info/72814612-Gambaran-profil-lipid-pada-pasien-hip ertensi-di-klinik-saintifikasi-jamu-hortusmedicus-tawangmangu-peristiwan-r-widhi-astana-1-dan-agus-triyono-1.html.
  3. Benslaiman SJ-, Galicia-García U, Larrea-Sebal A, et al. (2022). Pathophysiology of atherosclerosis. International Journal of Molecular Sciences 23, 3346. doi: 10.3390/ijms23063346.
  4. Chen S, Cheng W (2022). Relationship between lipid profiles and hypertension: A cross-sectional study of 62,957 chinese adult males. Frontiers in Public Health. doi: 10.3389/fpubh.2022.895499.
  5. Choi HM, Kim HC, Kang DR (2017). Sex differences in hypertension prevalence and control: Analysis of the 2010-2014 Korea National Health and Nutrition Examination Survey ed. Spracklen CN. PLoS One 12, e0178334. doi: 10.1371/journal.pone.0178334.
  6. Cuschieri, S. (2019) The STROBE guidelines. Saudi Journal of Anaesthesia. Wolters Kluwer Medknow Publications, S31–S34. doi: 10.4103/sja.SJA_543_18.
  7. Diana R, Khomsan A, Nurdin NM, et al (2018). Smoking habit, physical activity and hypertension among middle aged men. Media Gizi Indonesia 13, 57. doi: 10.20473/mgi.v13i1.57-61.
  8. Donni YR, Fionaliza, Triyana R, et al (2023). Overview of the lipid profile of hypertension patients at the installation of the Siti Rahmah RSI Padang outpatient clinic in 2021. Science Midwifery 10, 4757–4765. doi: 10.35335/midwifery.v10i6.1094.
  9. Feryadi R, Sulastri D, Kadri H (2014). Hubungan kadar profil lipid dengan kejadian hipertensi pada masyarakat etnik Minangkabau di Kota Padang Tahun 2012. Jurnal Kesehatan Andalas. doi: 10.25077/jka.v3i2.89.
  10. Huldani, Kaidah S, Adiputro DL, et al (2020). Effect of Total Cholesterol Levels and Triglycerides on Blood Pressure Hypertension Patients Overview against Puskesmas Banjar Ethnic Group in Cempaka Banjarmasin. Systematic Reviews in Pharmacy 11, 384–389. doi: 10.31838/srp.2020.4.57.
  11. Irnameria D, Nurjumareta V, Marlina L (2019). Description of triglyceride levels in the elderly who have hypertension. In Proceedings of the 1st International Conference on Inter-professional Health Collaboration (ICIHC 2018). Atlantis Press, Paris, France. Available at: https://www.atlantis-press.com/article/55916782.
  12. Islam S, Choudhury KN, Mainuddin A, et al (2014). Serum lipid profile and its association with hypertension in Bangladesh. Vascular Health and Risk Management 327. doi: 10.2147/VHRM.S61019.
  13. Jafar N, Hasan N, Hadju V, et al (2020). Gender aspect of triglyceride, HDL, and their ratio in high school teachers in Makassar City, Indonesia. Al-sihah: The Public Health Science Journal 12, 167. doi: 10.24252/al-sihah.v12i2.15911.
  14. James PA, Oparil S, Carter BL, et al (2014). 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA 311, 507. doi: 10.1001/jama.2013.284427.
  15. Kamajaya GAP, Lestari AW, Yasa IWS (2016). Hubungan antara profil dan hipertensi pada penderita stroke iskemik di RSUP Sanglah Denpasar tahun 2014. Med Udayana. Available at: https://ojs.unud.ac.id/index.php/eum/article/view/30457.
  16. Kingue S, Ngoe CN, Menanga AP, et al (2015). Prevalence and risk factors of hypertension in urban areas of cameroon: A nationwide population‐based cross‐sectional study. The Journal of Clinical Hypertension 17, 819–824. doi: 10.1111/jch.12604.
  17. Kuang H, Yang F, Zhang Y, et al (2018). The impact of egg nutrient composition and its consumption on cholesterol homeostasis. Cholesterol 2018, 1–22. doi: 10.1155/2018/6303810.
  18. Kurtkulagi O, Aktas G, Taslamacioglu Duman T, et al (2022). Correlation between serum triglyceride to HDL cholesterol ratio and blood pressure in patients with primary hypertension. Precision Medical Sciences 11, 100–105. doi: 10.1002/prm2.12080.
  19. Kusmiati M, Pratiwi D (2015). Gambaran profil lipid pada pasien yang mengalami hipertensi di Desa Setiajaya Kota Tasikmalaya. Kesehat Bakti Tunas Husada. Available at: https://ejurnal.univer sitas-bth.ac.id/index.php/P3M_JKBTH/article/vie w/15/15.
  20. Laurent S, Boutouyrie P (2020). Arterial stiffness and hypertension in the elderly. Frontiers in Cardiovascular Medicine. doi: 10.3389/fcvm.2020.544302.
  21. MacLaughlin, EJ, Slaton, JF, Young, RB. (2018). Blood pressure targets: How low should you go (and for whom)?. The Journal of Family Practice, 67, 416–425. Available at: https://www.mdedge.com/jcomjournal/article/168964/cardiology/blood-pressure-targets-how-low-should-you-go-and-whom.
  22. Mahmuda S, Yeasmin N, Abira M, et al (2018). Association of serum low density lipoprotein cholesterol and high density lipoprotein cholesterol with hypertension in adult female. Bangladesh Critical Care Journal 6, 74–79. doi: 10.3329/bccj.v6i2.38581.
  23. Maryati H (2017). The correlation of cholesterol levels with blood pressure hypertension patients in Sidomulyo Rejoagung Village District Ploso Jombang. Jurnal Keperawatan. doi: 10.22219/jk.v 8i2%20Juli.4030.
  24. Minister of Health of the Republic of Indonesia (2013). Riset Kesehatan Dasar 2013. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI Tahun 2013, Jakarta. Available at: https://repository.badankebijakan.ke mkes.go.id/id/eprint/4467/1/Laporan_riskesdas_2013_final.pdf.
  25. Minister of Health of the Republic of Indonesia (2018). Laporan Riset Kesehatan Dasar Jawa Timur 2018. Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan (LPB), Jakarta. Available at: https://www.scribd.com/document/4 11814045/22033-Hasil-Riskesdas-Jatim-2018.
  26. Nawi AM, Mohammad Z, Jetly K, et al (2021). The prevalence and risk factors of hypertension among the urban population in Southeast Asian countries: A systematic review and meta-analysis ed. Salvetti M. International Journal of Hypertension 2021, 1–14. doi: 10.1155/2021/6657003.
  27. Osuji CU, Omejua EG, Onwubuya EI, et al (2012). Serum lipid profile of newly diagnosed hypertensive patients in Nnewi, South-East Nigeria. International Journal of Hypertension 2012, 1–7. doi: 10.1155/2012/710486.
  28. Otsuka T, Takada H, Nishiyama Y, et al (2016). Dyslipidemia and the risk of developing hypertension in a working‐age male population. Journal of the American Heart Association. doi: 10.1161/JAHA.115.003053.
  29. Putri MPD, Suyasa IPGEA, Budhiapsari PI (2021). Hubungan antara dislipidemia dengan kejadian hipertensi di Bali Tahun 2019. AMJ (Aesculapius Medical Journal). Available at: https://www.ejournal.warmadewa.ac.id/index.php/amj/article/view/4084.
  30. Rafsanjani MS, Asriati A, Kholidha AN, et al (2019). Hubungan kadar High Density Lipoprotein (HDL) dengan kejadian hipertensi. Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan. doi: 10.33533/jpm.v13i2.1274.
  31. Rahminda P, Rasjad AS, Saefulloh A (2019). The relationship of blood lipid profile with hypertension in ischemic stroke patients. Prosiding Pendidikan Dokter. doi: 10.29313/kedokteran.v0i0.15259.
  32. Sari P (2017). Hubungan HDL dan LDL dengan target tekanan darah pada pasien hipertensi (thesis). Universitas Trisakti. Available at: http://repository.trisakti.ac.id/usaktiana/index.php/home/detail/detail_koleksi/0/SKR/judul/00000000000000093271/.
  33. Sawitri H, Maulina N (2022). Gambaran kadar profil lipid pada lansia di Panti Jompo Kota Lhokseumawe tahun 2021. GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh 1, 53. doi: 10.29103/jkkmm.v1i2.8220.
  34. Schober, P, Schwarte, LA. (2018). Correlation coefficients: Appropriate use and interpretation. Anesthesia and Analgesia 126, 1763–1768. doi: 10.1213/ANE.0000000000002864.
  35. Siagian EP (2017). Hubungan antara kadar LDL kolesterol dalam darah dengan kejadian hipertensi di Rumah Sakit Umum UKI (thesis). Universitas Kristen Indonesia. Available at: http://repository.uki.ac.id/1650/.
  36. Sondakh R, Pangemanan D, Marunduh S (2013). Pengaruh senam bugar lansia terhadap kadar trigliserida. Jurnal e-Biomedik. doi: 10.35790/ebm.1.1.2013.4631.
  37. Suci YP (2019). Hubungan kadar trigliserida dengan hipertensi pada pasien prolanis di Puskesmas Halmahera (thesis). Universitas Muhammadiyah Semarang. Available at: https://arpusda.semarangkota.go.id/uploads/data_karya_ilmiah/20210407143735-2021-04-07data_karya_ilmiah143732.pdf.
  38. Umar TP, Mariana M (2021). Correlation between total cholesterol level with blood pressure of hypertensive patients in Kalidoni, Palembang. Jurnal Epidemiologi Kesehatan Komunitas 207–212. doi: 10.14710/jekk.v6i1.8398.
  39. Wang X, Pei J, Zheng K, et al (2021). High‐density lipoprotein cholesterol levels are associated with major adverse cardiovascular events in male but not female patients with hypertension. Clinical Cardiology 44, 723–730. doi: 10.1002/clc.23606.
  40. Wu H, Yu Z, Huang Q (2022). Characteristics of serum lipid levels in patients with hypertension: A hospital-based retrospective descriptive study. BMJ Open 12, e054682. doi: 10.1136/bmjopen-2021-054682.
  41. Zhao D, Guallar E, Ouyang P, et al (2018). Endogenous sex hormones and incident cardiovascular disease in post-menopausal women. Journal of the American College of Cardiology 71, 2555–2566. doi: 10.1016/j.jacc.20 18.01.083.

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