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Submitted
26 July 2017
Accepted
26 July 2017
Published
8 August 2017
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Abstract

Singawalang leaf is used as a traditional medicine by the communities suffering from pneumonia due to TB disease. However, experiments to explain it's toxicity are few. Therefore, this study was conducted to disclose it's toxicity. This was an experimental laboratory study using post–test only control group design. The sampling method was simple random sampling. The animals were randomly divided into 4 (four) groups, each group consisted of 8 (eight) mice, the control group (P0) received distilled water as a solvent material. Treatment group 1 (P1) obtained ethanol extract of singawalang (Petiveria alliaceae) in low doses of 90 mg/kgbw. Treatment group 2 (P2) obtained ethanol extract of singawalang (Petiveria alliaceae) in medium doses of 180 mg/kgbw. Treatment group 3 (P3) obtained ethanol extract of singawalang (Petiveria alliaceae) in high doses of 360 mg/kgbw. Th extracts were given with sonde once a day for 30 days. Results showed that the leaf ethanol extract singawalang (Petiveria alliaceae) does not induce sub-acute necrosis effects on kidney of male white mice (Mus musculus) in doses 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw.

Keywords

Singawalang extract necrosis kidney

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  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

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How to Cite
Naibaho, A. H., Mustika, A., & Rahaju, A. S. (2017). SHORT-TERM TOXICITY TEST OF SINGALAWANG EXTRACT ON MALE WHITE RATS KIDNEY NECROSIS. Folia Medica Indonesiana, 52(1), 62–65. https://doi.org/10.20473/fmi.v52i1.5212
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References

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  2. Lu FC (1985). Basic Toxicology: Fundamentals, Target Organs, and Risk Assesment, Washington DC, Hemisphere Publishing Corporation, p 46-65
  3. Sarman (2008). Singawalang, si tangguh melawan TBC. Available from http://omnilogos.blogspot.com/2008/ 12/singawalang-si-tangguh-melawan-tbc.html. Accessed July 25, 2012
  4. Zakaria (2010). Uji Toksisitas Akut Daun Singawalang pada Mencit Putih Jantan. Research Report, Universitas Airlangga, Surabaya

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