SHORT-TERM TOXICITY TEST OF SINGALAWANG EXTRACT ON MALE WHITE RATS KIDNEY NECROSIS

Ardy Hamonangan Naibaho, Arifa Mustika, Anny Setijo Rahaju

= http://dx.doi.org/10.20473/fmi.v52i1.5212
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Abstract


Singawalang leaf is used as a traditional medicine by the communities suffering from pneumonia due to TB disease. However, experiments to explain it’s toxicity are few. Therefore, this study was conducted to disclose it’s toxicity. This was an experimental laboratory study using post–test only control group design. The sampling method was simple random sampling. The animals were randomly divided into 4 (four) groups, each group consisted of 8 (eight) mice, the control group (P0) received distilled water as a solvent material. Treatment group 1 (P1) obtained ethanol extract of singawalang (Petiveria alliaceae) in low doses of 90 mg/kgbw. Treatment group 2 (P2) obtained ethanol extract of singawalang (Petiveria alliaceae) in medium doses of 180 mg/kgbw. Treatment group 3 (P3) obtained ethanol extract of singawalang (Petiveria alliaceae) in high doses of 360 mg/kgbw. Th extracts were given with sonde once a day for 30 days. Results showed that the leaf ethanol extract singawalang (Petiveria alliaceae) does not induce sub-acute necrosis effects on kidney of male white mice (Mus musculus) in doses 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw.

Keywords


Singawalang extract, necrosis, kidney

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References


Lien Y-HH, Yong KC, Cho S, Igarashi S, Lai LW (2006). S1P1-Selective Agonist, SEW2871, ameliorates ischemic acute renal failure. Official Journal of The International Society of Nephrology 69, 1601-1608

Lu FC (1985). Basic Toxicology: Fundamentals, Target Organs, and Risk Assesment, Washington DC, Hemisphere Publishing Corporation, p 46-65

Sarman (2008). Singawalang, si tangguh melawan TBC. Available from http://omnilogos.blogspot.com/2008/ 12/singawalang-si-tangguh-melawan-tbc.html. Accessed July 25, 2012

Zakaria (2010). Uji Toksisitas Akut Daun Singawalang pada Mencit Putih Jantan. Research Report, Universitas Airlangga, Surabaya


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