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Submitted
5 April 2018
Accepted
5 April 2018
Published
5 April 2018
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Abstract

Colorectal carcinoma has high morbidity and mortality rate worldwide, in which over 90% are adenocarcinoma. Colorectal carcinoma is one of the most cancer that metastasize to the lymph node. Angiogenesis have an important role in tumor growth and metastasis. Hypoxia is the trigger factor for angiogenesis. Hypoxia induced factor-1 (HIF-1) is one critical protein directly reacting to hypoxia. HIF-1alpha, a HIF-1 subunit, is an important regulator of angiogenesis. This study analyzed HIF-1a expression in colorectal adenocarcinoma with and without regional lymph node metastasis. This study was to prove that HIF-1a has a role in regional lymph node metastasis in colorectal adenocarcinoma. An analytical observational study was conducted on thirty formalin fixed paraffin-embedded colorectal adenocarcinoma tissues from Anatomic Pathology Laboratory of Dr. Soetomo Hospital. Detection of HIF-1alpha expressions were performed with immunohistochemistry method, using HIF-1alpha antibody. It were statistically analyzed using Mann-Whitney and Kruskal- Wallis methods. There were no significant differences in the expression of HIF-1alpha in colorectal adenocarcinoma with or without lymph node (LN) metastasis (p>0.05). As a conclusion, this study showed that HIF-1alpha has no role in LN metastasis in colorectal adenocarcinoma.

Keywords

Colorectal adenocarcinoma HIF-1alpha regional LN

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  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

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How to Cite
Rumapar, L., Mustokoweni, S., & Rahniayu, A. (2018). The Role of HIF-1alpha in Regional Lymph Nodes Metastasis in Colorectal Adenocarcinoma. Folia Medica Indonesiana, 54(1), 1–5. https://doi.org/10.20473/fmi.v54i1.8042
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References

  1. Bosman FT, Carneiro F, Hruban R.H, Theise N.D (2010). Carcinoma of the colon and rectum. World Health Organization Classification of Tumours of the Digestive System. Lyon, IARC, 134-138
  2. Cao D, Hou M, Guan Y, Jiang M, Yang Y, Gou H (2009). Expression of HIF-1ï¡ and VEGF in colorectal cancer: association with clinical outcomes and prog-nostics implications. BMC Cancer 9, 432
  3. Decastel M, Andrea AM, Lubeth M (2014). Inflammatory and cell adhesion protein markers in colorectal cancer in patient seen at the teaching hospital of Guadalupe: Role of NF kappaB and P-selectin. J Cytol Histol 5, 276
  4. George ML, Tutton MG, Janssen F (2001). VEGF-A, VEGF-C and VEGF-C in colorectal cancer progress-ion. Nature publishing group, 420-427
  5. Hamilton SR, Aaltonen LA (2000). Pathology and Genetics of tumor of the Digestive System. Lyon, IARC Press, p 103-119
  6. Kwon HC, Kim SH, Oh SY (2010). Clinicopathological significance of nuclear factor-kappa B, HIF-1ï¡, and vascular endothelial growth factor expression in stage III colorectal cancer. Japanese cancer association 101, 1557-1561
  7. Masoud GN, Li W (2015). HIF-1α pahway: role, regu-lation and intervension for cancer therapy. Acta Pharmaceutica Sinica B
  8. Nathanson SD (2003). Insights into the mechanism of lymph node metastasis. American Cancer Society, 413-423.
  9. Powis G, Kirkpatrick L (2004). Hypoxia inducible fac-tor-1a as a cancer drug target. Molecular Cancer Therapeutics, p.647-654
  10. Shepherd NA, Warren BE, Williams GT (2013). Morson and Dawson's Gastrointestinal Pathology, 5th ed.. New Jersey, Blackwell Publishing Ltd., p 685-715
  11. Wincewicz A, Sulkowska M, Koda M (2007). Clinicopathological Significance and Linkage of the Distribution of HIF-1α and GLUT-1 in Human Primary Colorectal Cancer. Pathology Oncology Research vol 13, no.1, 15-20
  12. Wu Y, Jin M, Xu Z (2010). Clinicopathologic Signifi-cance of HIF-1ï¡, CXCR4, and VEGF Expression in Colon Cancer. Hindawi Publishing Corporation, p 1-10