Essential of Graptophyllum pictum for the medical and dental purposes
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Background: The use of plants for medicinal purposes continues to expand rapidly across the world. Up to 80% of the world's population is estimated to rely heavily on herbal medicines for their primary health care. Graptophyllum pictum leaves (GPL) have long been used as herbal medicine for several diseases or health conditions. However, until now, there have been only limited studies regarding laboratory experiments and the pharmacological effects of GPL. Purpose: To summarize the phytopharmacology aspect of GPL used for medical and dental purposes. Review(s): Based on the 36 articles included, GPL is widely used in medicine and dentistry, such as for treatment of hemorrhoids, periodontitis, and candidiasis, due to its anti-inflammatory, antioxidant, and antifungal properties. However, the current research study designs are still in vitro and in vivo experiments. Continuing experiments and clinical tests are needed to explore the essential use of the GPL. Conclusion: GPL can be used for medical and dental purposes due to its anti-inflammatory, antioxidant, antibacterial, and antifungal properties.
Ekor M. The growing use of herbal medicines : issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177.
Larsson DGJ. Antibiotic resistance in the environment. Nat Rev Microbiol. 2022;20(May):257–69.
HYSH N, Nurfatriani F, Indrajaya Y, Yuwati T, Ekawati S, Salminah M, et al. Mainstreaming Ecosystem Services from Indonesia ' s Remaining Forests. Sustainability. 2022;14(19):12124.
Kusumawati I, Rullyansyah S, Rizka A, Hestianah E, Matsunami K. Histomorphometric study of ethanolic extract of Graptophyllum pictum ( L .) Griff . leaves on croton oil-induced hemorrhoid mice : A Javanese traditional anti-hemorrhoid herb. J Ethnopharmacol. 2020;284(2022):114765.
Goswami M, Ojha A, Mehra M. A Narrative literature review on Phytopharmacology of a Caricature Plant: Graptophyllum pictum (L.) Griff. (Syn: Justicia picta Linn.). Asian Pacific J Heal Sci. 2021;8(3):44–7.
Kurniawati A. Expression of TLR-2 of Mice Infected by Mycobacterium Tuberculosis by Administration of Methanol Extract of Graftophyllum pictum L. Griff. In: International Seminar on Science and Technology (ISOTECH). Jember: University of Jember; 2014. p. 23–6.
Sartika S, Indradi RB. Pharmacological Activities of Daun Ungu Plants (Graptophyllum pictum L. Griff). Indones J Biol Pharm. 2021;1(2):88–96.
Singh P, Khosa RL, Mishra G, Tahseen MA. A phytopharmacological review on Justicia picta (Acanthaceae): A well known tropical folklore medicinal plant. J Coast Life Med. 2015;3(12):1000–2.
Prasetyo SA, Wisnu Y, Eriawan, Dharmana E, Susilaningsih N, Riwanto I. Gratophyllum Pictum (L.) Griff Extract as Anti-Inflammatory on Wistar Rat with Experimental Hemorrhoids. . Int Surg. 2020;
Ratnasari Y, Susanti S, Dhiani BA. Anti-inflammation and anti-platelet aggregation activities of the ethanolic extract of Graptophyllum pictum leaves in Wistar rats. Pharmaciana. 2020;10(2):167.
Azhar A, Riwanto I, Nugroho E, Susilaningsih N, Prajoko Y, Budiono P, et al. Antioxidant and Anti-inflammatory effect of Graptophyllumpictum ( L .) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids. Medica Hosp J Clin Med. 2020;7(2):422–6.
Hutagalung M, Budiono B, Prasetyo S, Riwanto I, Nugroho E, Prajoko Y, et al. Phlebotrophic Effect of Graptophyllum pictum ( L .) Griff . on Experimental Wistar Hemorrhoids. J Biomed Transl Res. 2019;5(1):1–4.
Elnitiarta J, Istiadi H, Hendrianingtyas M, Retnoningrum D. Pengaruh Ekstrak Daun Wungu terhadap Kadar Malondialdehid Darah pada Tikus Diabetes Melitus Tipe 1. Medica Hosp J Clin Med. 2021;8(2):139–43.
Excelinda T, Istiadi H, Retnoningrum D, Hendrianingtyas M. Pengaruh Ekstrak Daun Wungu Terhadap Luas Islet Pankreas Tikus Wistar Diabetes Melitus. Medica Hosp J Clin Med. 2021;8(1):91–7.
Leonereza A, Excelinda T, Elnitiarta J, Heri-Nugroho H, Hendrianingtas M, Retnoningrum D. Effectiveness of Graptophyllum pictum ( L .) Griff leaf extraction on blood glucose level in alloxan - induced Wistar rat. Food Res. 2020;4(Suppl. 3):123–6.
Rahmi H, Artika IM, Azwar NR, Sasongko D, Seno D, Nurcholis W. The Activity of Wungu Leaf ( Graptophyllum pictum ( L ) Griff ) Extract in Reducing Blood Glucose Level of Hyperglycemic Mice. Curr Biochem. 2014;1(2):83–8.
Kusumaningsih T, Firdausi A, Diyatri I, Ridwan RD, Arundina I. Antioxidant Effects of Graptophyllum pictum Leaf Extract on Malondialdehyde ( MDA ) Levels of Mice Induced By a Toxic Dose of Paracetamol. J Krishna Inst Med Sci. 2018;7(3):59–64.
Srinivasan KK, Mathew JE, Silva KJAD, Kumar N. Nephroprotective potential of Graptophyllum pictum against renal injury induced by gentamicin. Iran J Basic Med Sci. 2015;18(4):412–6.
Rakasiwi HL, Suhargo L. The effect of Graptophyllum pictum ( L .) Griff leaf extract on morphometry and calcium levels of ovariectomized mice femur The Effect of Graptophyllum pictum ( L .) Griff Leaf Extract on Morphometry and Calcium Levels of Ovariectomized Mice Femur. 2022;070017(July 2019).
Pranoto H. Qualiti of Spermatozoa and Fertility Index of Adult White Rat (Rattus novergicus L.) after Giving of Wungu Leaves. BIOLINK (Jurnal Biol Lingkung Ind Kesehatan). 2018;4(2):160–7.
Wanda G, Njimfo S, Awounfack C, Njamen D. Evaluation of the estrogenic properties of aqueous extracts of Tragia benthamii Baker (Euphorbiaceae) and Graptophyllum pictum (Acanthaceae) and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats. Int J Phytomedicine. 2016;8(3):366–78.
Fauziah R, Irmawati A, Isrul M. Uji Aktivitas Diuretik Ekstrak Etanol Daun Wungu (Graptophyllum pictum L. Griff) Terhadap Mencit (Mus musculus). J Pharm Mandala Waluya. 2022;1(1):37–45.
Prasetyo S, Wisnu Y, Nugroho E, Dharmana E, Susilaningsih N, Riwanto I. Role of micronize purified flavonoid fraction and ethanol Graptophyllum pictum extract on experimental anal ulcer healing. Study on Wistar rat. J Coloproctology. 2019;40(2):105–11.
Masyita M, Sayekti E, Nurlina N. Flavonoid Compounds of the Catechin from Wungu ( Graptophyllum pictum ( L .) Griff ) Leaves and the Sun Protecting Factor Value. J Akad Kim. 2022;11(1):31–8.
Friska YD, Hujjatusnaini N, Ayatussa'adah, Amin AM. The Potential Of Purple Leaves Ethanol Extract (Graptophyllum pictum L.) Against The Growth Of Staphylococcus aureus and Candida albicans. J Agron Tanam Trop. 2021;3(2):196–207.
Kusumaningsih T, Putra A, Aljunaid M. Antibacterial Differences Effect between Purple Leaves (Graptophyllum Pictum (L) Griff.) 70% And 96% Ethanol Extract Against Aggregatibacter Actinomycetemcomittans Bacteria. J Int Dent Med Res. 2021;14(2):519–24.
Rachim SA, Kurniawati A, Astuti P. The Effect of Purple Leaf Extract ( Graptophyllum pictum L . Griff ) to The Amount of Fibroblast in Gingiva Rat Wistar induced by Porphyromonas gingivalis. DENTA. 2021;14(28):94–100.
Diyatri I, Kusumaningsih T, Hidayanto AR. Analysis of the Expression of Macrophage among Periodontitis Rat Model after Treatment with Graptophyllum Pictum ( L .) Griff . Leaves Extract Gel. Malaysian J Med Heal Sci. 2020;16(4):92–6.
Kurniawati A, Praharani D, Handoko GV. Effectiveness of Graptophyllum pictum ( L .) Griff Leaves Extract Toward Porphyromonas gingivalis Adhesion to Neutrophils Digital Repository Universitas Jember. Malaysian J Med Heal Sci. 2020;16(Supp. 4):60–6.
Kurniawati A, Wahyukundari M, Astuti S. Potensi Ekstrak Daun Ungu dalam Menurunkan Jumlah Sel Osteoklas Tikus yang Diinduksi Porphyromonas gingivalis. Cakradonya Dent J. 2021;55(8):75–82.
Juniarti DE, Kusumaningsih T, Juliastuti WS, Soetojo A, Wungsu ND. Phytochemical Analysis and Antibacterial Activity of Purple Leaf Extract [ Graptophyllum pictum ( L .) Griff ] Against Streptococcus mutans. Acta Med Philipp. 2021;55(8):802–6.
Juniarti DE, Kusumaningsih T, Soetojo A, Prasetyo EP, Sunur YK. Antibacterial activity and phytochemical analysis of ethanolic purple leaf extract (Graptophyllum Pictum L.griff) on lactobacillus acidophilus. Malaysian J Med Heal Sci. 2021;17(April):71–3.
Dewi TP. In vitro study comparison of purple leaf extract as denture cleanser at different concentration towards S. mutans growth on flexible denture. Bali Med J. 2020;9(3):716–20.
Kurniawati A. Pengaruh Kumur Ekstrak Daun Ungu Terhadap Jumlah Bakteri dalam Saliva. Stomatognatic (Jurnal Kedokt Gigi Univ Jember). 2018;15(2):43–6.
Kurniawati A. Pengaruh Ekstrak Daun Ungu (EEDU) Graptophyllum Pictum L. Griff terhadap Aktivitas Fagositosis Monosit yang Dipapar Candida albicans. Dent (Jurnal Kedokt Gigi). 2018;12(1):126–33.
Juniarti DE, Kusumaningsih T, Soetojo A, Hariyani N. Effect of Purple Leaf Extract ( Graptophyllum Pictum ( L .) Griff ) on the Number of Macrophage Cells in Pulp Perforation. Indian J Forensic Med Toxicol. 2020;14(3):1846–51.
Zamyatina A, Heine H. Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways. Front Immunol. 2020;11(November):1–22.
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