LYMPHATIC FILARIASIS DRUG TREATMENT POLICIES IN EASTERN INDONESIA: WHAT TARGET CHARACTERISTICS MATTER?
Background: Lymphatic filariasis (LF) drug treatment compliance remains a challenge in Eastern Indonesia.
Aims: The study sought to determine which aspects of Eastern Indonesia's LF drug treatment compliance policies were most pertinent.
Methods: The 2018 Indonesian Basic Health Survey data was employed. The analysis units were adults (≥ 15 years) who had received LF drug treatment. LF drug treatment compliance was analyzed based on respondent characteristics (age, gender, marital status, education, occupation, wealth and comorbidities) using binary logistic regression.
Results: The proportion of adherence to LF treatment in Eastern Indonesia was 73.1%. Respondent characteristics that influenced LF treatment compliance were age group > 24 (aOR = 1.374, 95% CI: 1.305-1.447), female (aOR = 1.307, 95% CI: 1.263-1.353), all educated respondent status (aOR = 2.152, 95% CI: 2.043-2.268), and all employed respondents (aOR = 1.437, 95% CI: 1.365 - 1.512). Married respondents and those with all levels of wealth status were less likely to take LF drug treatment.
Conclusion: Policy focus on improving LF treatment compliance among the younger male, the less educated, the unemployed, and those with lower social economic status.
Keywords: compliance, Eastern Indonesia, lymphatic filariasis, public health
Agustini, A. and Indrawati, F. (2018) ‘Program Pemberian Obat Pencegahan Massal (POPM) Filariasis', Higeia Journal of Public Health Research and Development, 1(3), pp. 84–94. Available at: http://journal.unnes.ac.id/sju/index.php/higeia.
Biritwum, N.K. et al. (2019) ‘Progress towards lymphatic filariasis elimination in Ghana from 2000-2016: Analysis of microfilaria prevalence data from 430 communities', PLoS Neglected Tropical Diseases, 13(8). Available at: https://doi.org/10.1371/journal.pntd.0007115.
Boyd, A. et al. (2010) ‘A community-based study of factors associated with continuing transmission of lymphatic filariasis in Leogane, Haiti', PLoS Neglected Tropical Diseases, 4(3), pp. 1–10. Available at: https://doi.org/10.1371/journal.pntd.0000640.
Burgert-Brucker, C.R. et al. (2020) ‘Risk factors associated with failing pretransmission assessment surveys (Pre-tas) in lymphatic filariasis elimination programs: Results of a multi-country analysis', PLoS Neglected Tropical Diseases, 14(6), pp. 1–17. Available at: https://doi.org/10.1371/journal.pntd.0008301.
Deshpande, A. et al. (2020) ‘The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis', The Lancet Global Health, 8(9), pp. e1186–e1194. Available at: https://doi.org/10.1016/S2214-109X(20)30286-2.
Dickson, B.F.R. et al. (2021) ‘Risk factors for lymphatic filariasis and mass drug administration non-participation in Mandalay Region, Myanmar', Parasites and Vectors, 14(1), pp. 1–14. Available at: https://doi.org/10.1186/s13071-021-04583-y.
Durrheim, D.N. et al. (2004) ‘Editorial: Lymphatic filariasis endemicity – an indicator of poverty?', Tropical Medicine & International Health, 9(8), pp. 843–845. Available at: https://doi.org/10.1111/J.1365-3156.2004.01287.X.
Gunawardena, G.S.A. et al. (2007) ‘Impact of the 2004 mass drug administration for the control of lymphatic filariasis, in urban and rural areas of the Western province of Sri Lanka', Annals of Tropical Medicine & Parasitology, 101(4), pp. 335–341. Available at: https://doi.org/10.1179/136485907X176364.
Gunawardena, S. et al. (2007) ‘Factors influencing drug compliance in the mass drug administration programme against filariasis in the Western province of Sri Lanka', Transactions of the Royal Society of Tropical Medicine and Hygiene, 101(5), pp. 445–453. Available at: https://doi.org/10.1016/j.trstmh.2006.09.002.
Ikawati, B. et al. (2019) ‘Supporting factors to get coverage of malaria mass blood survey (MBS) above 80%: Lesson learn from gripit village, Banjarmangu sub district, Banjarnegara district', Indian Journal of Public Health Research and Development, 10(3), pp. 649–653. Available at: https://doi.org/10.5958/0976-5506.2019.00575.8.
Indonesia Ministry of Health (2020) Indonesia Health Profile. Jakarta: Indonesia Ministry of Health.
Inobaya, M.T. et al. (2018) ‘Mass drug administration and the sustainable control of schistosomiasis: Community health workers are vital for global elimination efforts', International Journal of Infectious Diseases, 66, pp. 14–21. Available at: https://doi.org/10.1016/j.ijid.2017.10.023.
Ipa, M. et al. (2016) ‘Analysis of mass drug coverage for prevention of filariasis in Bandung district with a system dynamic model approach.', Balaba, 12(1), pp. 31–38. Available at: http://ejournal2.litbang.kemkes.go.id/index.php/blb/article/view/721.
Kasturiratne, K.T. et al. (2001) ‘Compliance with the mass chemotherapy program for lymphatic filariasis', The Ceylon Medical Journal, 46(4), pp. 126–129. Available at: https://doi.org/10.4038/cmj.v46i4.6431.
Kerjapy, S.L., Titaley, C.R. and Sanaky, M. (2019) ‘Faktor-faktor Penerimaan Obat Pada Program Pemberian Obat Pencegahan Massal (POPM)', Pattimura Medical Review, 1(1). Available at: https://ojs3.unpatti.ac.id/index.php/pameri/article/view/1279.
Kouassi, B.L. et al. (2018) ‘Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea', Acta Tropica, 179, pp. 109–116. Available at: https://doi.org/10.1016/j.actatropica.2017.12.002.
Koyadun, S. and Bhumiratana, A. (2005) ‘Surveillance of imported bancroftian filariasis after two-year multiple-dose diethylcarbamazine treatment', The Southeast Asian Journal of Tropical Medicine and Public Health, 36(4), pp. 822–831. Available at: https://www.thaiscience.info/journals/Article/TMPH/10594791.pdf.
Krentel, A. et al. (2016) ‘Improving Coverage and Compliance in Mass Drug Administration for the Elimination of LF in Two "Endgame” Districts in Indonesia Using Micronarrative Surveys', PLoS Neglected Tropical Diseases, 10(11), pp. 1–22. Available at: https://doi.org/10.1371/journal.pntd.0005027.
Krentel, A., Fischer, P.U. and Weil, G.J. (2013) ‘A Review of Factors That Influence Individual Compliance with Mass Drug Administration for Elimination of Lymphatic Filariasis', PLoS Neglected Tropical Diseases, 7(11). Available at: https://doi.org/10.1371/journal.pntd.0002447.
Kulkarni, P. et al. (2020) ‘Mass drug administration programme against lymphatic filariasis-an evaluation of coverage and compliance in a northern Karnataka district, India', More..., 8(1), pp. 87–90. Available at: https://doi.org/10.1016/j.cegh.2019.04.013.
Laksono, A.D., Rukmini, R. and Wulandari, R.D. (2020) ‘Regional disparities in antenatal care utilization in Indonesia', PLoS ONE, 15(2), pp. e0224006–e0224006. Available at: https://doi.org/10.1371/journal.pone.0224006.
Lourens, G.B. and Ferrell, D.K. (2019) ‘Lymphatic Filariasis', Nursing Clinics of North America, 54(2), pp. 181–192. Available at: https://doi.org/10.1016/j.cnur.2019.02.007.
Manyeh, A.K. et al. (2020) ‘Exploring factors affecting quality implementation of lymphatic filariasis mass drug administration in bole and central gonja districts in northern ghana', PLoS Neglected Tropical Diseases, 14(8), pp. 12–23. Available at: https://doi.org/10.1371/journal.pntd.0007009.
Manyeh, A.K. et al. (2021) ‘Evaluating context-specific evidence-based quality improvement intervention on lymphatic filariasis mass drug administration in Northern Ghana using the RE-AIM framework', Tropical Medicine and Health, 49(1), pp. 16–16. Available at: https://doi.org/10.1186/s41182-021-00305-3.
Maryen, Y., Kusnanto, H. and Indriani, C. (2018) ‘Risk Factors of Lymphatic Filariasis in Manokwari, West Papua', Tropical Medicine Journal, 4(1), pp. 60–64. Available at: https://journal.ugm.ac.id/tropmed/article/view/37186.
Mathieu, E. et al. (2004) ‘Factors associated with participation in a campaign of mass treatment against lymphatic filariasis, in Leogane, Haiti', Annals of Tropical Medicine & Parasitology, 98(7), pp. 703–714. Available at: https://doi.org/10.1179/000349804X3135.
Meireles, B.M. et al. (2020) ‘Factors associated with malaria in indigenous populations: A retrospective study from 2007 to 2016', PLOS ONE. Edited by J. Moreira, 15(10), p. e0240741. Available at: https://doi.org/10.1371/journal.pone.0240741.
Nandha, B. et al. (2007) ‘Delivery strategy of mass annual single dose DEC administration to eliminate lymphatic filariasis in the urban areas of Pondicherry, South India: 5 years of experience', Filaria Journal, 6, pp. 1–6. Available at: https://doi.org/10.1186/1475-2883-6-7.
NIHRD (2019) The 2018 Indonesia Basic Health Survey (Riskesdas): National Report. Jakarta: National Institute of Health Research and Development of The Indonesia Ministry of Health.
Ogbonnaya, L.U. and Okeibunor, J.C. (2004) ‘Sociocultural Factors Affecting the Prevalence and Control of Lymphatic Filariasis in Lau Local Government Area, Taraba State', International Quarterly of Community Health Education, 23(4), pp. 341–371. Available at: https://doi.org/10.2190/AY5A-QAY4-6H8D-VEL7.
Oktarina, R. (2010) Faktor-Faktor Yang Berhubungan Dengan Praktek Minum Obat Pada Pengobatan Massal Filariasis Di Kelurahan Sukajadi Kabupaten Banyuasin Tahun 2009. Universitas Indonesia.
Purwantyastuti (2010) ‘Pemberian Obat Massal Pencegahan (POMP) Filariasis', Buletin Jendela Epidemiologi, 1(1), pp. 15–20.
Santhi, F. (2011) Kepatuhan Minum Obat Filariasis Pada Pengobatan Massal Berdasarkan Teori Health Belief Model Di Kelurahan Limo Depok Tahun 2011. Universitas Indonesia.
Sari, P.R., Ginandjar, P. and Saraswati, L.D. (2020) ‘Gambaran Kepatuhan Minum Obat Pencegahan Massal Filariasis (Studi Di Wilayah Kerja Puskesmas Jetak Kabupaten Semarang', Jurnal Kesehatan Masyarakat (e-Journal), 8(4), pp. 463–468. Available at: https://ejournal3.undip.ac.id/index.php/jkm/article/view/26982.
Sartirano, D. et al. (2023) ‘Strengths and limitations of relative wealth indices derived from big data in Indonesia', Front Big Data., 6: 1054156. Available at: https://doi.org/10.3389/fdata.2023.1054156.
Silumbwe, A. et al. (2017) ‘A systematic review of factors that shape implementation of mass drug administration for lymphatic filariasis in sub-Saharan Africa', BMC Public Health, 17(1). Available at: https://doi.org/10.1186/s12889-017-4414-5.
Sindhu, K.N. et al. (2023) ‘Perceptions Associated with Noncompliance to Community-Wide Mass Drug Administration for Soil-Transmitted Helminths', American Journal of Tropical Medicine and Hygiene, 109(4), pp. 830–834. Available at: https://doi.org/10.4269/ajtmh.23-0176.
Suharmiati, S., Laksono, A.D. and Astuti, W.D. (2013) ‘Review Kebijakan tentang Pelayanan Kesehatan Puskesmas di Daerah Ter pencil Perbatasan', Bull Heal Syst Res., 16: 109–11. Available at: https://www.neliti.com/publications/20839/up-review-kebijakan-tentang-pelayanan-kesehatan-puskesmas-di-daerah-terpencil-pe.
Sungpradit, S. and Sanprasert, V. (2020) ‘Lymphatic filariasis', in G. Misra and V.K. Srivastava (eds) Molecular Advancements in Tropical Diseases Drug Discovery. London: Elsevier Inc., pp. 65–94. Available at: https://doi.org/10.1201/9781420004946.ch8.
Taylor, M. et al. (2022) ‘Community views on mass drug administration for filariasis: a qualitative evidence synthesis', Cochrane Database of Systematic Reviews, 2022(2), pp. CD013638–CD013638. Available at: https://doi.org/10.1002/14651858.CD013638.pub2.
Titaley, C.R. et al. (2018) ‘Assessing knowledge about lymphatic filariasis and the implementation of mass drug administration amongst drug deliverers in three districts/cities of Indonesia', Parasites and Vectors, 11(1). Available at: https://doi.org/10.1186/s13071-018-2881-x.
Widawati, M. et al. (2020) ‘Sociodemographic, Knowledge, and Attitude Determinants of Lymphatic Filariasis Medication Adherence in Subang, Indonesia', 24(94), pp. 1–6. Available at: https://doi.org/10.2991/ahsr.k.200311.001.
Widiastuti, D. et al. (2021) ‘Adverse reactions following mass drug administration with diethylcarbamazine and albendazole for lymphatic filariasis elimination in West Sumatera, Indonesia', Southeast Asian Journal of Tropical Medicine and Public Health, 52(1), pp. 1–10. Available at: https://journal.seameotropmednetwork.org/index.php/jtropmed/article/view/381.
Widjanarko, B., Saraswati, L.D. and Ginandjar, P. (2018) ‘Perceived threat and benefit toward community compliance of filariasis' mass drug administration in Pekalongan district, Indonesia', Risk Management and Healthcare Policy, 11, pp. 189–197. Available at: https://doi.org/10.2147/RMHP.S172860.
Won, K.Y. et al. (2009) ‘Assessing the Impact of a Missed Mass Drug Administration in Haiti', PLoS Negl Trop Dis, 3(8): e443. Available at: https://doi.org/10.1371/journal.pntd.0000443.
World Bank (2020) ‘Total Population (2018). Public Data. [citation : 21 April 2020].'
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