Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid
Downloads
Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 "‹"‹before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.
Apostolou, M., Assi, S., Fatokun, A. & Khan, I. (2021). The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid Carriers. Journal of Pharmaceutical Sciences; 110; 2859-2872. doi: 10.1016/j.xphs.2021.04.012.
Avadhani, K. S., Manikkath, J., Tiwari, M., Chandrasekhar, M., Godavarthi, A., Vidya, S, M., Hariharapura, R. C., Kalthur, G., Udupa, N., dan Mutalik, S. (2017). Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and antiaging effects in UV radiation-induced skin damage. Research Article Drug Delivery. doi: 10.1080/10717544.2016.1228718.
Czajkowska-Kośnik, A., Szekalska, M., Winnicka, K. (2018). Nanostructured lipid carriers: a potential use for skin drug delivery systems. Department of Pharmaceutical Technology. Medical University of Bialystok. Poland. doi: 10.1016/j.pharep.2018.10.008
Ebtavanny, T.G., Soeratri, W., Rosita, N. (2018). Effect of Lipid Composition on Nanostructured Lipid Carrier (NLC) on Ubiquinone Effectiveness as an Anti-aging Cosmetics. International Journal of Drug Delivery Techonology.
Erawati, T., Hariyadi, D. M., Rosita, N., dan Purwanti, T. (2019). The Anti-inflammatory Activity of p-methoxycinnamic acid (PMCA) in the Nanostructured lipid carrier (NLC) system using combinations of solid lipid, beeswax-oleum cacao and liquid lipid, Virgin Coconut oil (VCO). Research J. Pharm. and Tech. 12(8). doi: 10.5958/0974-360X.2019.00617.6
Gianeti, M., Mercurio, D., Campos, P. (2013). The use of green tea extract in cosmetic formulations: not only an antioxidant active ingredient. Dermatologic Therapy, Vol.26. 267–271. doi: 10.1111/j.1529-8019.2013.01552.x
Jordan, M., Nayel, A., Brownlow, B., dan Elbayoumi, T. (2012). Development and Evaluation of Tocopherol-Rich Argan Oil-Based Nanoemulsions as Vehicles Possessing Anticancer Activity. Journal of Biomedical Nanotechnology Vol. 8, 944–956, 2012. USA. doi: 10.1166/jbn.2012.1460.
Kamila, A.R.. (2017). dalam Kulit Sehat Dimulai dari Kadar pH yang Tepat. Yuk Ketahui Lebih Lanjut Tentang pH Kulit di Sini!, https://journal.sociolla.com/beauty/ph-kulit-wajah/ (Accessed: 4 Januari 2021).
Kelidari, H.R., Saeedi, M., Akbari, K., Morteza-Semnani, K., Valizadeh, H., Maniruzzaman, M., Farmoudeh, A., Nokhodchi, A. (2017). Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability. AAPS PharmSciTech, Vol. 18, No. 5. doi: 10.1208/s12249-016-0621-0.
Manea, A., Vasile, B.S., Meghea, A. (2014). Antioxidant and antimicrobial activities of green tea extract loaded into nanostructured lipid carriers. Acade´mie des sciences. Published by Elsevier Masson SAS. doi:10.1016/j.crci.2013.07.015
Muller, R.H., Radtke, M.., Wissing, S.A., 2002. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) in cosmetic and Dermatological Preparations. Advance Drug Delivery. Rev. 54, p. S131-S155. doi: 10.1016/s0169-409x(02)00118-7.
Paruvathanahalli, Rajinikanth, S., dan chellian, J. (2016). Development And Evaluation Of Nanostructured Lipid Carrier-Based Hydrogel For Topical Delivery Of 5-Fluorouracil. International Journal of Nanomedicine. doi: 10.2147/IJN.S117511.
Pornputtapitak, Pantakitcharoenkul., Teeranachaideekul., Sinthiptharakoon., Sapcharoenkun, Meemuk. (2019). Effect of Oil Content on Physiochemical Characteristics of γ-Oryzanol-Loaded Nanostructured Lipid Carriers. J. Oleo Sci. 68, (8) 699-707. doi: 10.5650/jos.ess18127.
Rohmah, M,. Raharjo., S., Hidayat, C., dan Martin, R. (2019). Formulasi dan Stabilitas Nanostructured Lipid Carrier dari Campuran Fraksi Stearin dan Olein Minyak Kelapa Sawit. Jurnal Aplikasi Teknologi Pangan.
Rosita, N., Nailufa, Y., Hariyadi, D.W. (2019). Characteristics, Stability and Activity of Epigallocatechin Gallate (EGCG)- Chitosan Microspheres: Effect of Polymer Concentration. Research J. Pharm. and Tech; 13(5): 2303-2309. doi: 10.5958/0974-360X.2020.00415.1
Saedi, A., Rostamizadeh, K., Parsa, M., Dalali, N, Ahmadi, N. (2018). Preparation and Characterization of Nanostructured Lipid Carriers as Drug Delivery System: Influence of Liquid Lipid Types on Loading and Cytotoxicity. School of Pharmacy Zanjan University of Medical Sciences. Iran. doi: 10.1016/j.chemphyslip.2018.09.007.
Scalia, S., Trotta, V., Bianchi, A. (2014). In Vivo Human Skin Penetration of (-) Epigallocatechin-3-Gallate from topical formulations. Department of Chemical and Pharmaceutical Sciences, University of Ferrara, Italy. doi: 10.2478/acph-2014-0017.
Soeratri, W., Hidayah, R., Rosita. (2019). Effect Of Combination Soy Bean Oil And Oleic Acid To Characteristic,Penetration, Physical Stability Of Nanostructure Lipid Carrier Resveratrol. Fol Med Indones, Vol. 55 No. 3 September : 213-222. doi:10.20473/fmi.v55i3.15505
Suprobo, G. dan Rahmi, D. (2015). Pengaruh Kecepatan Homegenisasi Terhadap Sifat Fisika Dan Kimia Krim Nanopartikel Dengan Metode High Speed Homogenization (HSH). Jurnal Litbang Industri Vol. 5 No. 1, 1-12.
Tichota, D.M; Silva, C; Lobo J.M.S; Amaral M.H. (2014). Design, Characterization, And Clinical Evaluation Of Argan Oil Nanostructured Lipid Carriers to Improve Skin Hydration. International Journal Of Nanomedicine. doi: 10.2147/IJN.S64008.
Umar, A. (2021). Formulasi Dan Evaluasi Fisik Sediaan Balsem dari Minyak Atsiri Daun Serai Wangi. Jurnal Kesehatan Luwu Raya.
Yapar, W., Inal, O., Erdal, M. (2013). Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil. Acta Pharm. 63; 531–543. doi: 10.2478/acph-2013-0037.
Copyright (c) 2022 JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
1. The copyright of this journal belongs to the Editorial Board and Journal Manager with the author's knowledge, while the moral right of the publication belong to the author.
2. The formal legal aspect of journal publication accessibility refers to the Creative Commons Attribution-Non-Commercial-Share Alike (CC BY-NC-SA), which implies that the publication can be used for non-commercial purposes in its original form.
3. Every publication (print/electronic) is open access for educational, research, and library purposes. In addition to the objectives mentioned above, the editorial board is not responsible for copyright infringement
.jpg)
