Application of the Simplex Lattice Design Methode to Determine the Optimal Formula Nanoemulsion with Virgin Coconut Oil and Palm Oil
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Background: The success of nanoemulsion preparation is characterized by characteristics such as small droplet size, polydispersity index (PDI), and % transmittance, which are close to 100%. One of these factors is the type of oil component used. The Simplex Lattice Design (SLD) method can be used to determine the ratio of oil combinations to obtain an optimal nanoemulsion formula. Objective: The application of the Simplex Lattice Design (SLD) method can help researchers speed up the acquisition of optimal formulas without trial and error so that nanoemulsion formulas that meet specifications can be obtained. Methods: This research uses the Simplex Lattice Design (SLD) method with Design of Expert Version 13 software, with an upper limit value for oil (VCO and Palm Oil) of 2.66% and a lower limit value for oil (VCO and Palm Oil) of 0, which then The results of several formulas come out and characterization testing is carried out to get the best formula from the recommendations produced by the software. Results: The results of the Simplex Lattice Design (SLD) showed that oil affected the droplet size and PDI (p <0.05). Six optimal formulas were obtained, and after testing in the laboratory, there was no significant difference between the results of the SLD program and those of the laboratory (Sig. <0.05). Conclusion: This study shows that the Simplex Lattice Design (SLD) method is very effective.
Amrina, F., Purwanto, A., & Riauwati, R. (2024). Optimasi Formula Krim Ekstrak Etanol Daun Patikan Kebo (Euphorbia Hirta L.) Dengan Metode Simplex Lattice Design. Jurnal Insan Farmasi Indonesia, 7(2), 53-65.
Aprilya, A., Rahmadevi, R., & Meirista, I. (2021). Formulasi Nanoemulsi dengan Bahan Dasar Minyak Ikan (Oleum Iecoris Aselli): Nanoemulsion Formulation with Fish Oil (Oleum Iecoris Aselli) Base Ingredients. Jurnal Sains Dan Kesehatan, 3(3), 370-375.
Bashir, M., Ahmad, J., Asif, M., Khan, S. U. D., Irfan, M., Y Ibrahim, A., ... & AS Abourehab, M. (2021). Nanoemulgel, an innovative carrier for diflunisal topical delivery with profound anti-inflammatory effect: In vitro and in vivo evaluation. International Journal of Nanomedicine, 1457-1472.
Bolton, S.. 1997. Pharmaceutical Statistics : Practical and Clinical Applications, 3 rd Ed, Marcel Dekker Inc., New York.
Das, S. S., Verma, P. R. P., & Singh, S. K. (2020). Screening and preparation of quercetin doped nanoemulsion: Characterizations, antioxidant and anti-bacterial activities. LWT, 124, 109141.
Dwiputri, A. S., Pratiwi, L., & Nurbaeti, S. N. (2022). Optimasi Formula Sabun Organik Sebagai Scrub Kombinasi VCO, Palm Oil, Dan Olive Oil Menggunakan Metode Simplex Lattice Design. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 6(1).
Erawati, T., Firdaus, A. W., & Soeratri, W. (2017). Virgin coconut oil as oil phase in tretinoin nanoemulsion. International Journal of Drug Delivery Technology, 7(1).
Gao, L., & Li, B. (2023). The Effects of Surfactant and Metal Ions on the Stability and Rheological Properties of Nanoemulsions Loaded with Gardenia Yellow Pigment. Applied Nano, 4(2), 61-74.
Ghasemiyeh, P., & Mohammadi-Samani, S. (2020). Potential of nanoparticles as permeation enhancers and targeted delivery options for skin: Advantages and disadvantages. Drug design, development and therapy, 3271-3289.
Huda, N., & Wahyuningsih, I. (2016). Karakterisasi self-nanoemulsifying drug delivery system (SNEDDS) minyak buah merah (Pandanus conoideus Lam.). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 3(2), 49-57.
Jadhav, R. P., Koli, V. W., Kamble, A. B., & Bhutkar, M. A. (2020). A review on nanoemulsion. Asian Journal of Research in Pharmaceutical Science, 10(2), 103-108.
Li, H., Peng, Q., Guo, Y., Wang, X., & Zhang, L. (2020). Preparation and in vitro and in vivo study of asiaticoside-loaded nanoemulsions and nanoemulsions-based gels for transdermal delivery. International Journal of Nanomedicine, 3123-3136.
Mahiya, M., Ratnasari, D., & Utami, M. R. (2022). Optimasi Formula SNEDDS (Self-Nanoemulsifying Drug Delivery System) Ekstrak Daun Kejibeling Menggunakan Metode SLD (Simplex Lattice Design). Jurnal Ilmiah Wahana Pendidikan, 8(11), 124-129.
Nandita, S. P., Kuncahyo, I., & Harjanti, R. (2021). Formulation and Optimization of Furosemide Snedds With Variation Concentration of Tween 80 and PEG. Journal of Fundamental and Applied Pharmaceutical Science, 2(1).
Ningsih, I. Y., Faradisa, H., Cahyani, M. D., Rosyidi, V. A., & Hidayat, M. A. (2020). The formulation of ginger oil nanoemulsions of three varieties of ginger (Zingiber officinale Rosc.) as natural antioxidant. J. Res. Pharm.(Online), 24, 914-924.
Pratiwi, G., Ramadhiani, A. R., Shiyan, S., & Chabib, L. (2024). Combination Simplex Lattice Design Modelling with Chemometrics Analysis for Optimization Formula Self-Nano Emulsion Loaded Quercetin.
Rachman, E. S., Soeratri, W., & Erawati, T. (2023). Characteristics and Physical Stability of Nanoemulsion as a Vehicle for Anti-Aging Cosmetics: A Systematic Review. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia Vol, 10(1), 62-85.
Rakhma, D. N., Nailufa, Y., Najih, Y. A., & Wahjudi, H. (2021). Optimization Of Skin Moisturizer Formula Based On Fixed Oil (VCO, Olive Oil, And Jojoba Oil): Optimasi Formula Pelembab Kulit Berbasis Minyak Nabati (VCO, Minyak Zaitun dan Minyak Jojoba). Journal Pharmasci, 6(2), 109-114.
Son, H. Y., Lee, M. S., Chang, E., Kim, S. Y., Kang, B., Ko, H., ... & Kim, Y. (2019). Formulation and characterization of quercetin-loaded oil in water nanoemulsion and evaluation of hypocholesterolemic activity in rats. Nutrients, 11(2), 244.
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