Efektivitas Penggunaan Kombinasi Vitamin B pada Pasien Neuropati Diabetikum

Rizaldy Taslim Pinzon, Rosa De Lima Renita Sanyasi

= http://dx.doi.org/10.20473/jfiki.v5i12018.6-12
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Abstract


Pendahuluan: Neuropati diabetikum (ND) adalah salah satu bentuk neuropati yang paling umum dijumpai. Terapi yang ada saat ini lebih ditujukan untuk mengatasi gejala. Pemberian kombinasi vitamin B ditujukan bukan hanya untuk mengendalikan gejala, namun memperbaiki fungsi saraf. Penelitian terdahulu tentang vitamin untuk neuropati diabetika masih terbatas dan belum konklusif. Tujuan: Penelitian ini bertujuan untuk menilai efektivitas vitamin B kombinasi terhadap gejala klinis neuropati diabetika dan kualitas hidup (QoL) pada pasien diabetes melitus (DM). Metode: Metode yang digunakan dalam penelitian ini adalah metode penelitian observasional pada pasien DM dengan ND. Setiap subjek memperoleh vitamin B kombinasi yang terdiri dari vitamin B1, vitamin B6, dan vitamin B12 dengan dosis masing-masing secara berurutan 100 mg, 100 mg, dan 5 mg. Gejala klinis ND dinilai dengan menggunakan Total Symptom Score (TSS). QoL dinilai dengan menggunakan kuesioner SF-8. Penilaian dilakukan sebanyak 5 kali, yaitu penilaian awal hingga 3 bulan. Hasil: Total terdapat 104 subjek pada awal penelitian. Tujuh subjek tidak dapat mengikuti penelitian sampai selesai, sehingga tersisa 97 subjek pada akhir penelitian. Terdapat perbaikan berbagai gejala ND, yang meliputi sensasi nyeri tertusuk, sensasi nyeri terbakar, kesemutan, dan rasa kebas/baal, setelah pemberian vitamin B kombinasi. Perubahan tersebut bermakna secara statistik (p < 0,0001). Hal serupa juga tampak pada QoL. Terdapat perbaikan QoL dari awal penelitian hingga akhir penelitian. Perbedaan tersebut bermakna secara statistik (physical component summary dengan p < 0,0001 dan mental component summary dengan p = 0,0001). Kesimpulan: Vitamin B kombinasi efektif untuk memperbaiki gejala klinis dan meningkatkan kualitas hidup pada pasien ND.

Keywords


vitamin B kombinasi, diabetes mellitus, neuropati diabetikum, TSS, SF-8

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