Effect of Total Amount of Metformin HCl on the Characteristics of Metformin-Ca Alginate Microspheres

Dewi Melani Hariyadi, Noorma Rosita, Tiara Jeni Rosadi

= http://dx.doi.org/10.20473/jfiki.v5i12018.13-19
Abstract views = 400 times | downloads = 324 times

Abstract


Introduction: Metformin hydrochloride (metformin HCl) is an antidiabetic drug that is specifically used for type 2 diabetes mellitus (DM) and belongs to the biguanide antidiabetic drugs. Objective: The aim of this research was to determine the effect of total amount of metformin HCl on the characteristics of metformin HCl-Ca alginate microspheres using aerosolization technique. Methods: The total amount of metformin were 0.5 g (F1); 1 g (F2); 1.5 g (F3) and 2 g (F4). Drug was encapsulated into alginate and was crosslinked using CaCl2. Results: The results showed that drug loadings were 5.09%; 9.61%; 13.11%; and 15.09% respectively, while the entrapment efficiencies were 48.35%; 41.99%; 38.67%; and 30.53%. The yields were 80.92%; 74.12%; 68.27%; and 59.11% respectively. Based on the statistical analysis, it was found that there were significant differences between formulas. Particles of formulas decreased as the amount of drug increased. The resulting sizes were 1.82 μm (F1); 1.96 μm (F2); 2.1 μm (F3); and  2.97 μm (F4). Conclusion: It can be concluded that amount of drug significantly affected the characteristics of metformin-alginate microspheres.


Keywords


metformin HCl, alginate, microspheres, amount of drug, aerosolization

Full Text:

PDF

References


Abdelwahed, W., Degobert, G., Stainmesse, S. & Fessi, H. (2006). Freeze-drying of Nanoparticles: Formulation, Process and Storage Considerations. Advanced Drug Delivery Reviews; 58; 1688–1713.

Alagusurandam, M., Madhu, S. C. C., Umashankari, K., Attuluri, V. B., Lavanya, C. & Ramkanth, S. (2009). Microspheres as a Novel Drug Delivery System. International Journal of ChemTech Research; 1; 526-534.

Balasubramaniam, J., Vinay, U., Rao, M., Vasudha, J. B. & Rajinikanth, P. S. (2007). Sodium Alginate Microspheres of HCl Metformin: Formulation and In Vitro Evaluation. Current Drug Delivery; 4; 249-256.

Choudhury, P. K. & Mousumi, K. (2009). Controlled Release Metformin Hydrochloride Hicrospheres of Ethyl Cellulose Prepared by Different Methods and Study on the Polymer Affected Parameters. Journal of Microencapsulation; 26; 46-53.

Erdinc, B. I. (2007). Micro/Nanoencapsulation of Proteins Whitin Alginate/Chitosan Matrix by Spray Drying. Thesis; Queen’s University, Brisbane.

Goundanavar, P. S., R. S., Bagali, C. S. & Patil, S. M. (2010). Design and Characterization of Diclofenac Sodium Microbeads by Ionotropic Gelation Technique. International Journal of Pharma and Bio Sciences; 1; 1-10.

Hariyadi, D. M., Tutiek, P. & Rahma, N. N. (2014). Effect of Lactose and Maltodectrin on the Physical Characteristics of Ovalbumin-loaded Alginate Microspheres Produced by Aerosolization. International Journal of Life Sciences Biotechnology and Pharma Research; 5; 26-29.

Kuo, C. K. & Peter, X. M. (2001). Ionically Crosslinked Alginate Hydrogels as Scaffolds for Tissue Engineering: Part 1. Structure, Gelation Rate and Mechanical Properties. Biomaterials; 22; 511-521.

Laura, T. R. F., Antonio, P. P. & Mercedes, E. C. (2010). Inulin Like Lyoprotectant of Bovine Plasma Proteins Concentrated by Ultrafiltration. Food Research International; 43; 788-796.

Lee, K. Y. & David, J. M. (2012). Alginate: Properties and Biomedical Applications. Progress in Polymer Science; 37; 106–126.

Martin, M. (2002). Surfactans and Polymers in Drug Delivery. New York: Marcel Dekker, Inc.

Mujoriya, R. & Bodla, R. B. (2011). Microsphere – An Overview. Journal of Biology, Agriculture and Healthcare; 1; 27-33.

Patil, J. S., Kamalapur, M. V., Marapur, S. C. & Kadam, D. V. (2010). Ionotropic Gelation and Polyelectrolyte Complexation: The novel Thechniques to Design Hydrogel Particulate Sustained, Modulated Drug Delivery System. Digest Journal of Nanomaterials and Biostructures; 5; 241-248.

Rastogi, R., Sultana, Y., Aqil, M., Kumar, S., Chuttani, K. & Mishar, A. K. (2007). Alginate Microspheres of Isoniazid for Oral Sustained Drug Delivery. International Journal of Pharmaceutics; 334; 71-77.

Yang, L., Bifang, Z., Liqum, W., Qiuyi, L. & Li-Ming, Z. (2007). Amphiphilic Cholesteryl Grafted Sodium Alginate Derivative: Synthesis and Self Assembly in Aqueous Solution. Carbohydrate Polymers; 68; 218-225.

Zafar, A., Bhattacharyya, A., Bajpai, M., Yasir, M. & Asif, M. (2014). Formulation and In Vitro Characterization of Floating Gel Beads of Metformin Hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences; 7; 2356-2362.


Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

View JFIKI Stats

                

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License