The evaluation of mandibular bone density in chronic periodontitis models

Yuliana Mahdiyah Da’at Arina, F. Ferdiansyah, Mohamad Rubianto

= http://dx.doi.org/10.20473/j.djmkg.v51.i4.p210-215
Abstract views = 128 times | views = 92 times

Abstract


Background: Bone density, an important factor in functional bone quality, can affect the success of implant osteointegration or orthodontic treatment. A number of studies report that chonic periodontitis constitutes one risk factor of osteoporosis characterized by low bone mineral density and that the mandible is susceptible to osteoporosis. Purpose: The purpose of this study was to evaluate mandibular bone density in animal subjects suffering from chronic periodontitis. Methods: 40 male Wistar rats were divided into four chronic periodontitis groups and four control groups (each group n=5). As chronic periodontitis models, the subjects were injected with 2×109 CFU/ml of Porphyromonas gingivalis in the sulcular gingiva, whereas control group members were injected with normal saline. After 2, 3, 4 and 6-week injection periods, the subjects were sacrificed and radiographic examination of the mandibular bone subsequently performed. Mandibular bone density was evaluated by histometric analysis. Results: The mandibular bone density in members of the chronic periodontitis group was significantly lower than those of the control group (p<0.05). The reduced mandibular bone density in the chronic periodontitis group was in line with the protracted bouts of periodontitis. Conclusion: Reduced mandibular bone density was found in the chronic periodontitis model. The longer the duration of a bout of chronic periodontitis, the greater the reduction in mandibular bone density.

Keywords


chronic periodontitis; mandibular bone density; Porphyromonas gingivalis

Full Text:

PDF

References


Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza’s clinical periodontology. 12th ed. Philadelphia: Saunders Elsevier; 2015. p. 706-22.

Yuce HB, Toker H, Ozdemir H, Goze F. Effects of two experimental models of osteoporosis on alveolar bone: histopathologic and densitometric study. Oral Health Dent Manag. 2014; 13(4): 915–20.

Jonasson G, Billhult A. Mandibular bone structure, bone mineral density, and clinical variables as fracture predictors: a 15-year follow-up of female patients in a dental clinic. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116(3): 362–8.

Lohana M, Suragimath G, Abbayya K, Varma S, Zope S, Kale V. A study to assess and correlate osteoporosis and periodontitis in selected population of Maharashtra. J Clin Diagn Res. 2015; 9(6): ZC46-50.

Newman MG, Takei HH, Klokkevold PR, Carranza FA. Carranza’s clinical periodontology. 12th ed. Philadelphia: Saunders Elsevier; 2015. p. 309-20.

Lafzi A, Amid R, Kadkhodazadeh M, Ahrara F. Is there any association between systemic bone mineral density and clinical manifestations of periodontal disease? J Periodontol Implant Dent. 2012; 4(2): 49–55.

Tonguç MÖ, Büyükkaplan UŞ, Fentoğlu Ö, Gümüş BA, Çerçi SS, Kırzıoğlu FY. Comparison of bone mineral density in the jaws of patients with and without chronic periodontitis. Dentomaxillofacial Radiol. 2012; 41(6): 509–14.

Brennan-Calanan RM, Genco RJ, Wilding GE, Hovey KM, Trevisan M, Wactawski-Wende J. Osteoporosis and oral infection: independent risk factors for oral bone loss. J Dent Res. 2008; 87(4): 323–7.

Guiglia R, Di Fede O, Lo Russo L, Sprini D, Rini G-B, Campisi G. Osteoporosis, jawbones and periodontal disease. Med Oral Patol Oral Cir Bucal. 2013; 18(1): e93–9.

Kusumawardani B, Arina YMD, Purwandhono A. Evaluation of the placental development and fetal growth in a pregnant rat model induced by periodontal disease. BJOG An Int J Obstet Gynaecol. 2015; 122(S1): 9–10.

de Molon RS, de Avila ED, Boas Nogueira AV, Chaves de Souza JA, Avila-Campos MJ, de Andrade CR, Cirelli JA. Evaluation of the host response in various models of induced periodontal disease in mice. J Periodontol. 2014; 85(3): 465–77.

Oz HS, Puleo DA. Animal models for periodontal disease. J Biomed Biotechnol. 2011; 2011: 1–8.

How KY, Song KP, Chan KG. Porphyromonas gingivalis: an overview of periodontopathic pathogen below the gum line. Front Microbiol. 2016; 7: 1–14.

Mysak J, Podzimek S, Sommerova P, Lyuya-Mi Y, Bartova J, Janatova T, Prochazkova J, Duskova J. Porphyromonas gingivalis: major periodontopathic pathogen overview. J Immunol Res. 2014; 2014: 1–8.

Han X, Lin X, Yu X, Lin J, Kawai T, LaRosa KB, Taubman MA. Porphyromonas gingivalis infection-associated periodontal bone resorption is dependent on receptor activator of NF-κB ligand. Infect Immun. 2013; 81(5): 1502–9.

Zhang W, Ju J, Rigney T, Tribble G. Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model. BMC Oral Health. 2014; 14: 1–9.

Hienz SA, Paliwal S, Ivanovski S. Mechanisms of bone resorption in periodontitis. J Immunol Res. 2015; 2015: 1–10.

Graves DT, Li J, Cochran DL. Inflammation and uncoupling as mechanisms of periodontal bone loss. J Dent Res. 2011; 90(2): 143–53.

Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep. 2014; 3: 1–10.

Di Benedetto A, Gigante I, Colucci S, Grano M. Periodontal disease: linking the primary inflammation to bone loss. Clin Dev Immunol. 2013; 2013: 1–7.

Yu J-H, Huang H-L, Liu C-F, Wu J, Li Y-F, Tsai M-T, Hsu J-T. Does orthodontic treatment affect the alveolar bone density? Medicine (Baltimore). 2016; 95(10): 1–10.


Refbacks

  • There are currently no refbacks.


View My Stats