The management of herpes labialis, oral thrush and angular cheilitis in cases of oral diabetes

Maharani Laillyza Apriasari

= http://dx.doi.org/10.20473/j.djmkg.v52.i2.p76-80
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Abstract


Background: As reported in several studies, prolonged or uncontrolled cases of diabetes mellitus (DM) may induce a more extreme inflammatory response. Mucosal lesions can be observed in patients who present this systemic condition. Purpose: The purpose of this study was to elaborate the management of herpes labialis, oral thrush and angular cheilitis as oral manifestations of diabetes. Case: A 49-year-old male complained of having experienced painful lip ulceration for the preceding seven days. The anamnesis of the patient revealed that, prior to lip ulceration, he had experienced high fever and malaise in addition to frequent urination at night and a tingling sensation in the toes and fingertips on waking. Case management: The patient was referred to undergo blood count, fasting blood glucose and oral glucose tolerance tests. The blood test result confirmed the patient to be suffering from DM and anemia. The immunocompromised condition of the patient prompted the occurrence of herpes labialis, oral thrush and angular cheilitis. Conclusion: Multidisciplinary treatment for herpes labialis resulting in oral candidiasis in DM patients is indispensable. Concurrent infection with HSV and candidiasis necessitates a more prolonged healing process. Consequently, it is a essential to treat the hyperglycemia which induces an immunocompromised state in diabetic patients.

Keywords


angular cheilitis; diabetes mellitus; herpes labialis; management; oral thrush

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References


Putra RJS, Achmad A, Rachma H. Kejadian efek samping potensial terapi obat anti diabetes pasien diabetes melitus berdasarkan algoritma naranjo. Pharm J Indones. 2017; 2(2): 45–50.

Badan Penelitian dan Pengembangan Kesehatan. Hasil Utama Riskesdas 2018. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018. p. 66–71.

Barbieri J, Fontela PC, Winkelmann ER, Zimmermann CEP, Sandri YP, Mallet EKV, Frizzo MN. Anemia in patients with type 2 diabetes mellitus. Anemia. 2015; 2015: 1–7.

Apriasari ML, Ainah Y, Febrianty E, Carabelly AN. Antioxidant effect of channa micropeltes in diabetic wound of oral mucosa. Int J Pharmacol. 2019; 15(1): 137–43.

Apriasari ML, Puspitasar D. Effect of Channa micropeltes for increasing lymphocyte and fibroblast cells in diabetic wound healing. J Med Sci. 2018; 18(4): 205–10.

Al-Maskari AY, Al-Maskari MY, Al-Sudairy S. Oral manifestations and complications of diabetes mellitus: a review. Sultan Qaboos Univ Med J. 2011; 11(2): 179–86.

Indurkar MS, Maurya AS, Indurkar S. Oral manifestations of diabetes. Clin Diabetes. 2016; 34(1): 54–7.

Apriasari ML, Baharuddin EM. Penyakit infeksi rongga mulut. Surakarta: Yuma Pustaka; 2012. p. 6–8, 11–3.

Almasdy D, Sari DP, Suhatri S, Darwin D, Kurniasih N. Evaluasi penggunaan obat antidiabetik pada pasien diabetes melitus tipe-2 di suatu rumah sakit pemerintah kota Padang – Sumatera Barat. J Sains Farm Klin. 2015; 2(1): 104–10.

Hatta I, Firdaus IWAK, Apriasari ML. The prevalence of oral mucosa disease of Gusti Hasan Aman Dental Hospital in Banjarmasin, South Kalimantan. Dentino J Kedokt Gigi. 2018; 2(2): 211–4.

Apriasari ML, Tuti H. Stomatitis aftosa rekuren oleh karena anemia. J Dentofasial. 2010; 9(1): 39–46.

Apriasari ML. Methisoprinol as an immunomodulator for treating infectious mononucleosis. Dent J (Majalah Kedokt Gigi). 2016; 49: 1–4.

Apriasari ML, Endariantari A, Oktaviyanti IK. The effect of 25% Mauli banana stem extract gel to increase the epithel thickness of wound healing process in oral mucosa. Dent J (Majalah Kedokt Gigi). 2015; 48(3): 150–3.

Apriasari ML. Peroxide alkaline for cleansing the baby bottle nipple to prevent oral thrush relaps. Dent J (Majalah Kedokt Gigi). 2013; 46(2): 75–9.

Lyu X, Zhao C, Hua H, Yan Z. Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis. Drug Des Devel Ther. 2016; 10: 1161–71.

Zawar V, Godse K, Sankalecha S. Chronic urticaria associated with recurrent genital herpes simplex infection and success of antiviral therapy — a report of two cases. Int J Infect Dis. 2010; 14(6): e514–7.

McDonald P, Krishnan-Natesan S. Concurrent reactivation of VZV and HSV-2 in a patient with uncontrolled diabetes mellitus: a case report. Eur J Med Case Reports. 2017; 1(3): 108–13.

Ascione C, Sala A, Mazaheri-Tehrani E, Paulone S, Palmieri B, Blasi E, Cermelli C. Herpes simplex virus-1 entrapped in Candida albicans biofilm displays decreased sensitivity to antivirals and UVA1 laser treatment. Ann Clin Microbiol Antimicrob. 2017; 16(1): 1–8.

Mohammadi F, Javaheri MR, Nekoeian S, Dehghan P. Identification of Candida species in the oral cavity of diabetic patients. Curr Med Mycol. 2016; 2(2): 1–7.


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