The role of continuous moderate-intensity exercise on increasing collagen density after tooth extraction
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Background: The wound healing process post-extraction is expected to be quick, which can reduce the risk of complications and restore normal tissue function. A minimum oxygen supply needs to be met so that acceleration of the wound healing process can occur. Wound healing can be accelerated by continuous moderate-intensity exercise with increasing tissue oxygenation. Collagen requires oxygen in the procollagen formation process to support wound healing. Purpose: This study aimed to prove the role of continuous moderate-intensity exercise in increasing collagen density in the dental sockets of Wistar rats (Rattus norvegicus) after tooth extraction. Methods: Four groups of Wistar rats were created: control groups K1 (on day 3) and K2 (on day 7), and treatment groups K3 (on day 3) and K4 (on day 7). K1 and K2 were submerged in a bucket of water, and K3 and K4 received daily moderate-intensity exercise for a duration of two weeks. The rats' incisors were extracted on the day 15. Post-extraction collagen density was measured on day 3 (K1 and K3) and on day 7 (K2 and K4). The one-way ANOVA test and post-hoc Tukey test were used in the statistical analysis of the data. Results: There was a significant difference between all groups (p: 0.0001; p<0.05). Group K4 had a higher collagen density than the other groups. Conclusion: Continuous moderate-intensity exercise played a role in increasing the density of collagen in the rat tooth socket after tooth extraction.
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Ngangi RS, Mariati NW, Hutagalung BSP. Gambaran Pencabutan Gigi Di Balai Pengobatan Rumah Sakit Gigi Dan Mulut Universitas Sam Ratulangi Tahun 2012. e-GIGI. 2013; 1(2): 1–7. doi: https://doi.org/10.35790/eg.1.2.2013.3211
World Health Organization. Oral health. 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/oral-health. Accessed 2022 Sep 30.
FDI World Dental Federation. The challenge of oral disease – A call for global action. The oral health atlas. 2nd ed. Geneva: FDI World Dental Federation; 2015. p. 17. web: https://www.fdiworlddental.org/oral-health-atlas
Karalis M, Pavlidis TE, Psarras K, Ballas K, Zaraboukas T, Rafailidis S, Symeonidis N, Marakis GN, Sakantamis AK. Effect of experimentally induced liver cirrhosis on wound healing of the post-extraction tooth socket in rats. Eur Surg Res. 2008; 40(2): 190–6. doi: https://doi.org/10.1159/000110860
Shafer WG, Hine MK, Levy BM. Shafer's textbook of oral pathology. 7th ed. Rajendran A, Sivapathasundharam B, editors. Elsevier; 2012. p. 567–70. web: https://books.google.co.id/books/about/Shafer_s_Textbook_of_Oral_Pathology.html?id=WnhtAwAAQBAJ&redir_esc=y
Afiyah LL, Medawati A. Efektifitas gel ekstrak Pithecellobium lobatum Benth. pada proses kesembuhan luka pascapencabutan gigi: Studi pada Cavia cobaya dengan pengamatan histologis. Mutiara Med J Kedokt dan Kesehat. 2017; 17(2): 86–91. doi: https://doi.org/10.18196/mm.170205
Xue M, Jackson CJ. Extracellular matrix reorganization during wound healing and its impact on abnormal scarring. Adv wound care. 2015; 4(3): 119–36. doi: https://doi.org/10.1089/wound.2013.0485
Sunarjo L, Hendari R, Rimbyastuti H. Manfaat xanthone terhadap kesembuhan ulkus rongga mulut dilihat dari jumlah sel PMN dan fibroblast. ODONTO Dent J. 2015; 2(2): 17–24. doi: https://doi.org/10.30659/odj.2.2.17-24
Sen CK. Wound healing essentials: Let there be oxygen. Wound Repair Regen. 2009; 17(1): 1–18. doi: https://doi.org/10.1111/j.1524-475X.2008.00436.x
Babalola TK, Abasi UU. Effects of exercise on plasma lactic acid and body temperature in man, following a standardized meal. Bangladesh J Med Sci. 2018; 17(2): 270–4. doi: https://doi.org/10.3329/bjms.v17i2.35883
Oki AS, Alviansyah MF, Khoswanto C, Rahayu RP, Luthfi M. Acceleration of post-tooth extraction socket healing after continuous aerobic and anaerobic physical exercise in Wistar rats (Rattus norvegicus). Dent J. 2020; 53(4): 196–200. doi: https://doi.org/10.20473/j.djmkg.v53.i4.p196-200
Irmawati A, Rachma LA, Sidarningsih S, Hatta MN, Arundina I, Aljunaid M. Exercise as a method to reduce the risk of oral cancer: A narrative review. Dent J. 2022; 55(1): 56–61. doi: https://doi.org/10.20473/j.djmkg.v55.i1.p56-61
Oki AS, Bimarahmanda ME, Rahardjo MB. Increased number of fibroblasts and neovascularization after tooth extraction in wistar rats with moderate-intensity continuous exercise. J Int Dent Med Res. 2018; 11(3): 840–5. pdf: http://www.jidmr.com/journal/wp-content/uploads/2019/01/14_D18_630_Aqsa_Sjuhada.pdf
Setyadewi W, Oki AS, Sunariani J. Moderate intensity physical exercise effect on PMN and macrophage expression in Rattus norvegicus post tooth extraction. J Int Dent Med Res. 2017; 10(2): 364–7. pdf: http://www.jidmr.com/journal/wp-content/uploads/2017/05/31_D17_388_Jenny_Sunariani_Alexander_Nugraha4.pdf
Irmawati A, Jasmin N, Sidarningsih. The effect of moderate exercise on the elevation of Bax/Bcl-2 ratio in oral squamous epithelial cells induced by benzopyrene. Vet world. 2018; 11(2): 177–80. doi: https://doi.org/10.14202/vetworld.2018.177-180
Irmawati A, Giffari FZ, Oki AS. The effect of moderate exercise on vascular endothelial growth factor expression during tooth socket wound healing after tooth extraction. J Postgrad Med Inst. 2018; 32(1): 19–23. web: https://www.researchgate.net/publication/324160954
Rüegg MA, Meinen S. Histopathology in Masson Trichrome stained muscle sections. TREAT-NMD Neuromuscular Network; 2014. p. 1–9. web: https://treat-nmd.org/wp-content/uploads/2016/08/cmd-MDC1A_M.1.2.003-67.pdf
Permatasari N, Handayani MP. Efek jus belimbing (averrhoa carambola linn.) Dalam meningkatkan pembentukan kolagen pada soket pasca pencabutan gigi tikus wistar. Prodenta J Dent. 2013; 1(1): 7–14. web: https://jprodenta.ub.ac.id/index.php/prodenta/article/view/31%0Ahttps://jprodenta.ub.ac.id/index.php/prodenta/article/viewFile/31/29
Purnomo W, Bramantoro T. Pengantar metodologi penelitian bidang kesehatan. Surabaya: Airlangga University Press; 2018. p. 98–100. web: https://catalog.aup.unair.ac.id/Kedokteran/298-pengantar-metodologi-penelitian-bidang-kesehatan.html
Zhafirah R, Nur Aida A, Hirawan H, Wardana T. Wound healing induces VEGF expression stimulated by forest honey in palatoplasty Sprague Dawley. Dent J. 2023; 56(1): 48–52. doi: https://doi.org/10.20473/j.djmkg.v56.i1.p48-52
Potter PA, Perry AG. Buku ajar: Fundamental keperawatan - Konsep, proses, dan praktik. Volume 2. 4th ed. Jakarta: EGC; 2005. p. 1153. web: https://digilib.unuja.ac.id/index.php?p=show_detail&id=14723
Fauzia M, Dewanti AP. The effect of lime (Citrus Aurantifola Swingle) peel extract in periodontal dressings on the number of fibroblasts in the gingival wound healing process. Dent J. 2022; 55(2): 81–7. doi: https://doi.org/10.20473/j.djmkg.v55.i2.p81-87
Primadina N, Basori A, Perdanakusuma DS. Proses penyembuhan luka ditinjau dari aspek mekanisme seluler dan molekuler. Qanun Med. 2019; 3(1): 31–43. doi: https://doi.org/10.30651/jqm.v3i1.2198
Purnama H, Sriwidodo, Ratnawulan S. Proses penyembuhan dan perawatan luka: Review sistematik. Farmaka. 2017; 15(2): 251–8. web: https://jurnal.unpad.ac.id/farmaka/article/view/13366
Hanafiah OA, Hanafiah DS, Syaflida R. The effect of 3% binahong leaf extract gel on the wound healing process of post tooth extraction. Dent J. 2021; 54(2): 57–62. doi: https://doi.org/10.20473/j.djmkg.v54.i2.p57-62
Barrett K, Brooks H, Boitano S, Barman S. Ganong's review of medical physiology. 23rd ed. New York: McGraw Hill Medical; 2010. p. 261–72. web: https://books.google.co.id/books/about/Ganong_s_Review_of_Medical_Physiology_23.html?id=fnEc16_ArFUC&redir_esc=y
Kumarudin A. Pengaruh latihan aerobik terhadap peningkatan volume oksigen maksimal (VO2 Maks) pada remaja usia 18-20 tahun. 2013. p. 1–11. web: https://eprints.ums.ac.id/24107/
Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock RE. Schwartz's principles of surgery. 10th ed. New York: McGraw-Hill Medical; 2016. p. 242–6. web: https://books.google.co.id/books/about/Schwartz_s_Principles_of_Surgery_ABSITE.html?id=w3TCCwAAQBAJ&source=kp_book_description&redir_esc=y
Prahasanti C, Arini NL, Wulan KD, Hendro OV, Wijaksana IKE, Ulfah N, Kusumawardani B, Hari P, Abullais SS. The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen. Dent J. 2023; 56(2): 115–21. doi: https://doi.org/10.20473/j.djmkg.v56.i2.p115-121
Wu Z, Korntner SH, Mullen AM, Zeugolis DI. Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering. Biomater Biosyst. 2021; 4: 100030. doi: https://doi.org/10.1016/j.bbiosy.2021.100030
Preston RR, Wilson TE. Lippincott's illustrated reviews: Physiology. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012. p. 48. web: https://meded.lwwhealthlibrary.com/book.aspx?bookid=782
Patel H, Alkhawam H, Madanieh R, Shah N, Kosmas CE, Vittorio TJ. Aerobic vs anaerobic exercise training effects on the cardiovascular system. World J Cardiol. 2017; 9(2): 134–8. doi: https://doi.org/10.4330/wjc.v9.i2.134
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