Casein phosphopeptide-amorphous calcium phosphate varnish versus dentin desensitizer in the treatment of non-carious dentin hypersensitivity
Downloads
Background: Dentin hypersensitivity (DH) is one of the most common conditions clinicians encounter in clinical practice. New techniques are continuously being set forth to treat this condition. In recent times, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has garnered attention owing to its ability to improve remineralization and prevent enamel demineralization. Consequently, it has been indicated as an advanced treatment for DH. Purpose: This clinical trial aims to assess the efficacy of a CPP-ACP varnish in the management of non-carious cervical hypersensitivity and compare it with that of a dentin desensitizer. Methods: Patients between the ages of 20 and 65 years who reported to our institute with complaints of DH were selected for this study. Forty teeth were chosen for this study and randomly assigned to two groups. The test group was treated with a CPP-ACP varnish (MI Varnish®, GC Corporation, Japan), while the control group was treated with a dentin desensitizer (Gluma®, Heraeus-Kulzer, Germany). Dentin hypersensitivity assessments were conducted during pre-treatment, immediately following treatment, and 2 and 4 weeks after treatment. Statistical analysis was performed after data collection. Results: An intragroup comparison showed both the CPP-ACP varnish and the dentin desensitizer achieved a maximum decrease in sensitivity in the time interval from baseline to post-op, and these desensitizing effects were sustained through the second and fourth week following treatment. An intergroup comparison revealed no statistically significant difference in sensitivity between the two groups at different time intervals. Conclusion: It could be concluded that CPP-ACP varnish and dentin desensitizer possess similar efficacy in the treatment of DH.
Downloads
Liu X-X, Tenenbaum HC, Wilder RS, Quock R, Hewlett ER, Ren Y-F. Pathogenesis, diagnosis and management of dentin hypersensitivity: an evidence-based overview for dental practitioners. BMC Oral Health. 2020; 20: 220. doi: https://doi.org/10.1186/s12903-020-01199-z
Iskandar CHM, Mulya HB, Kusumawati WP, Kusuma ARP. Purple sweet potato (Ipomea Batatas P.) as dentin hypersensitivity desensitization gel. Dent J. 2015; 48(4): 170–2. doi: https://doi.org/10.20473/j.djmkg.v48.i4.p170-172
Haneet RK, Vandana LK. Prevalence of dentinal hypersensitivity and study of associated factors: a cross-sectional study based on the general dental population of Davangere, Karnataka, India. Int Dent J. 2016; 66(1): 49–57. doi: https://doi.org/10.1111/idj.12206
Barunawati SB, Artama WT, Saleh S, Sunarintyas S, Murti YB. Effects of manufacturing methods of abalone gel as a desensitisation material on the closing of dentinal tubules. Dent J. 2020; 53(2): 99–106. doi: https://doi.org/10.20473/j.djmkg.v53.i2.p99-106
Forouzande M, Rezaei-Soufi L, Yarmohammadi E, Ganje-Khosravi M, Fekrazad R, Farhadian M, Farmany A. Effect of sodium fluoride varnish, Gluma, and Er,Cr:YSGG laser in dentin hypersensitivity treatment: a 6-month clinical trial. Lasers Med Sci. 2022; 37(7): 2989–97. doi: https://doi.org/10.1007/s10103-022-03583-3
Divyapriya G, Yavagal P, Veeresh D. Casein phosphopeptide-amorphous calcium phosphate in dentistry: An update. Int J Oral Heal Sci. 2016; 6(1): 18–25. doi: https://doi.org/10.4103/2231-6027.186660
Pithon MM, dos Santos AFS, dos Santos AM, da Silva Fidalgo TK, de França AKA, Coqueiro RS, de Andrade ACDV, Oliveira DD, Maia LC. Effectiveness of chewing gum containing CPP-ACP for remineralisation of demineralised enamel around orthodontic brackets: An in situ study. Pesqui Bras Odontopediatria Clin Integr. 2022; 22: 1–11. doi: https://doi.org/10.1590/pboci.2022.025
Ghosh A, Mazumder D. Comparative evaluation of treatment of noncarious cervical hypersensitivity by a fluoride varnish, a dentin bonding agent, and Er, Cr:YSGG laser: An in vivo study. J Conserv Dent. 2019; 22(6): 516. doi: https://doi.org/10.4103/JCD.JCD_215_20
Abuzinadah SH, Alhaddad AJ. A randomized clinical trial of dentin hypersensitivity reduction over one month after a single topical application of comparable materials. Sci Rep. 2021; 11: 6793. doi: https://doi.org/10.1038/s41598-021-86258-3
Kazak M, Dönmez N. Development of dentin bonding systems from past to present. Bezmialem Sci. 2019; 7(4): 322–30. doi: https://doi.org/10.14235/bas.galenos.2019.3102
Kunarti S, Saraswati W, Lashari DM, Salma N, Nafatila T. Enamel remineralisation-inducing materials for caries prevention. Dent J. 2021; 54(3): 165–8. doi: https://doi.org/10.20473/j.djmkg.v54.i3.p165-168
Budi HS, Pebriani I. The protein level and molecular weight analysis in different children's toothpaste, which probably induced hypersensitivity. Contemp Clin Dent. 2020; 11(3): 245–8. doi: https://doi.org/10.4103/ccd.ccd_394_19
Saraf J, Amirisetty R, Zade RM, Mangalekar SB. Evaluation of effectiveness of CPP- ACP combination in treating dentinal hypersensitivity following non surgical periodontal therapy – A randomized clinical trial. Chhattisgarh J Heal Sci. 2013; 1(1): 32–4. web: https://www.researchgate.net/publication/283081769
Bapna RA, Shetty N, Mathur A, Bali A, Taki M, Devani VR. Efficacy of casein phosphopeptide varnish reducing dental hypersensitivity: A randomized clinical trial. Iberoam J Med. 2020; 3(1): 7–11. doi: https://doi.org/10.53986/ibjm.2021.0003
Sharma H, Gupta C, Thakur S, Srivastava S. Comparative evaluation of calcium phosphate-based varnish and resin-modified glass ionomer-based varnish in reducing dentinal hypersensitivity: A randomized controlled clinical trial. Eur J Dent. 2017; 11(4): 491–5. doi: https://doi.org/10.4103/ejd.ejd_127_17
Bou Chebel F, Zogheib CM, Baba NZ, Corbani KA. Clinical comparative evaluation of Nd:YAG laser and a new varnish containing casein phosphopeptides"amorphous calcium phosphate for the treatment of dentin hypersensitivity: A prospective study. J Prosthodont. 2018; 27(9): 860–7. doi: https://doi.org/10.1111/jopr.12984
Guanipa Ortiz MI, Alencar C de M, Freitas De Paula BL, Alves EB, Nogueira Araújo JL, Silva CM. Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial. Lin C-P, editor. PLoS One. 2019; 14(12): e0225501. doi: https://doi.org/10.1371/journal.pone.0225501
Murugesan S, Kumar P, Reddy BN, Arumugam K, Mohankumar P, Chandrasekaran K. Novel management of hypersensitive dentin using propolis-based herbal desensitizing agents: An in vitro scanning electron microscopic study. J Contemp Dent Pract. 2021; 22(9): 1030–4. doi: https://doi.org/10.5005/jp-journals-10024-3154
Zhou K, Liu Q, Yu X, Zeng X. Laser therapy versus topical desensitising agents in the management of dentine hypersensitivity: A meta"analysis. Oral Dis. 2021; 27(3): 422–30. doi: https://doi.org/10.1111/odi.13309
Mahdian M, Behboodi S, Ogata Y, Natto ZS. Laser therapy for dentinal hypersensitivity. Cochrane Database Syst Rev. 2021; 2021(7): 594. doi: https://doi.org/10.1002/14651858.CD009434.pub2
Copyright (c) 2024 Dental Journal
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
- Every manuscript submitted to must observe the policy and terms set by the Dental Journal (Majalah Kedokteran Gigi).
- Publication rights to manuscript content published by the Dental Journal (Majalah Kedokteran Gigi) is owned by the journal with the consent and approval of the author(s) concerned.
- Full texts of electronically published manuscripts can be accessed free of charge and used according to the license shown below.
- The Dental Journal (Majalah Kedokteran Gigi) is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License