Deoxypyridinoline and mineral levels in gingival crevicular fluid as disorder indicators of menopausal women with periodontal disease

Agustin Wulan Suci Dharmayanti, Banun Kusumawardani

= http://dx.doi.org/10.20473/j.djmkg.v50.i3.p131-137
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Abstract


Background: Menopause is a phase of a woman’s life marked by menstruation cycle cessation and an increased risk of periodontal disease. It can be caused by estrogen deficiency which alters the microenvironment in the sulcular gingival area and influences the composition and flow of gingival crevicular fluid (GCF). GCF has been widely studied as a non-invasive diagnostic and predictive tool for periodontal diseases. However, insufficient reports exist that explore its role as a predictive or diagnostic tool for bone loss detection in menopausal women. Purpose: This study aimed was to investigate deoxypyridinoline (DPD) and mineral levels that could be utilized as disorder indicators in menopausal women with periodontal disease. Methods: This study represents a form of analytical observation. Eighty-four patients of the Dental Hospital, University of Jember who fulfilled certain criteria were recruited. The subjects were divided into two main groups based on the presence of periodontal disease, (gingivitis=26; periodontitis=58) which were subsequently divided into three sub-groups based on their menopausal phase (pre-menopausal=26; perimenopausal=40; post-menopausal=18). GCF was collected using paper points from the buccal site of a posterior maxillary tooth with each subject having their GCF taken on only one occasion. DPD analysis was conducted by means of an ELISA test. The analysis of calcium, magnesium and sodium incorporated the use of an Atomic Absorption Spectroscope (AAS), while that of phosphor was by means of a spectrophotometer. Statistical analyses were performed using a comparison and correlation test (p<0.05). Results: There were significant differences in DPD and the mineral level of GCF in menopausal women with periodontal diseases (p<0.05). DPD and mineral levels showed significant correlation to those of menopausal women with periodontal diseases and a pH of GCF. Conclusion: DPD and mineral level in GCF could be used as disorder indicators in menopausal women with periodontal diseases.

Keywords


menopause; periodontal disease; deoxypyridinoline; mineral; gingival crevicular fliud

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References


Dharmayanti AWS. Deoxypyridinoline level in gingival crevicular fluid as alveolar bone loss biomarker in periodontal disease. Dent J (Maj Ked Gigi). 2012; 45(2): 102–6.

Mariotti A. Sex steroid hormones and cell dynamics in the periodontium. Crit Rev Oral Biol Med. 1994; 5(1): 27–53.

Markou E, Eleana B, Lazaros T, Antonios K. The influence of sex steroid hormones on gingiva of women. Open Dent J. 2009; 3: 114–9.

Yoshihara A, Hayashi Y, Miyazaki H. Relationships among bone turnover, renal function and periodontal disease in elderly Japanese. J Periodontal Res. 2011; 46: 491–6.

Bhardwaj A, Bhardwaj S. Effect of menopause on women's periodontium. J Midlife Health. 2012; 3(1): 5–9.

Guiglia R, Di-Fede O, Lo-Russo L, Sprini D, Rini G, Campisi G. Osteoporosis, jawbones and periodontal disease. Med Oral Patol Oral Cir Bucal. 2013; 18(1): e93–9.

Khurshid Z, Mali M, Naseem M, Najeeb S, Zafar M. Human gingival crevicular fluids (GCF) proteomics: an overview. Dent J. 2017; 5: 1–8.

Barros SP, Williams R, Offenbacher S, Morelli T. Gingival crevicular as a source of biomarkers for periodontitis. Periodontol 2000. 2016; 70(1): 53–64.

Hirose A, Terauchi M, Akiyoshi M, Owa Y, Kato K, Kubota T. Depressive symptoms are associated with oxidative stress in middleaged women: a cross-sectional study. Biopsychosoc Med. 2016; 10: 1–6.

Phipps AI, Ichikawa L, Bowles EJA, Carney PA, Kerlikowske K, Miglioretti DL, Buist DSM. Defining menopausal status in epidemiologic studies: a comparison of multiple approaches and their effects on breast cancer rates. Maturitas. 2010; 67(1): 60–6.

Ardiani DK, Dharmayanti AWS, Pujiastuti P. Kadar fosfor (P) dalam cairan sulkus gingiva pada penderita penyakit periodontal. IDJ. 2014; 3(1): 1–9.

Sharma R, Sharma P, Kumar P, Gupta G. Role of magnesium in post-menopausal women with osteoporosis and osteopenia. Asian J Pharm Clin Res. 2016; 9:198–9.

Hosthor SS, Mahesh P, Priya SA, Sharada P, Jyotsna M, Chitra S. Quantitative analysis of serum levels of trace elements in patients with oral submucous fibrosis and oral squamous cell carcinoma: a randomized cross-sectional study. J Oral Maxillofac Pathol. 2014; 18(1): 46–51.

Koregol AC, More SP, Nainegali S, Kalburgi N, Verma S. Analysis of inorganic ions in gingival crevicular fluid as indicators of periodontal disease activity: a clinico-biochemical study. Contemp Clin Dent. 2011; 2(4): 278–82.

Penido MGMG, Alon US. Phosphate homeostasis and its role in bone health. Pediatr Nephrol. 2012; 27: 2039–48.

Razmandeh R, Nasli-Esfahani E, Heydarpour R, Faridbod F, Ganjali MR, Norouzi P, Larijani B, Khoda-Amorzideh D. Association of zinc, copper and magnesium with bone mineral density in Iranian postmenopausal women – a case control study. J Diabetes Metab Disord. 2014; 13: 1–6.

Gur A, Colpan L, Nas K, Cevik R, Sarac J, Erdogan F, Duz MZ. The role of trace minerals in the pathogenesis of postmenopausal osteoporosis and a new effect of calcitonin. J Bone Min Metab. 2002; 20: 39–43.

Kasuma N. Correlation between magnesium and alkaline phosphatase from gingival crevicular fluid periodontal diseases. Dent J (Maj Ked Gigi). 2015; 48(3): 130–4.

He LY, Zhang XM, Liu B, Tian Y, Ma WH. Effect of magnesium ion on human osteoblast activity. Braz J Med Biol Res. 2016; 49(7): 1–6.

Fijorek K, Püsküllüoğlu M, Tomaszewska D, Tomaszewski R, Glinka A, Polak S. Serum potassium, sodium and calcium levels in healthy individuals - literature review and data analysis. Folia Med Cracov. 2014; 54(1): 53–70.

Boras VV, Brailo V, Rogić D, Puhar I, Bosnjak A, Badovinac A, Rogulj AA. Salivary electrolytes in patients with periodontal disease. RJPBCS. 2016; 7(2): 8–14.

Moe SM. Disorders involving calcium, phosphorus, and magnesium. Prim Care. 2008; 35(2): 1–19.

Terauchi M, Honjo H, Mizunuma H, Aso T. Effects of oral estradiol and levonorgestrel on cardiovascular risk markers in postmenopausal women. Arch Gynecol Obstet. 2012; 285: 1647–56.


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