Ivermectin Versus Selamectin and Fipronil as Ectoparasite Treatment in Cats and Dogs: A Literature Review
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Ectoparasite is commonly found on the skin and can cause dermatological problems. In veterinary practices, ivermectin, selamectin, and fipronil are commonly used to treat ectoparasitosis. This article aims to deeply examines the indications and contraindications of ivermectin, selamectin and fipronil. Ectoparasites are commonly found in cats and dogs and make up a large percentage of cases compared to other diseases. Therefore, it is important to have an understanding of the drugs that are effective against ectoparasites. In the past, ivermectin was a popular antiparasitic drug due to its high efficacy. However, its safety is not directly proportional its efficacy. Ivermectin has adverse effects, as evidenced by numerous case reports of overdose, intoxication, and interference with certain organ functions. In the field of pharmacology, many new drugs have been developed with the expectation of improved efficacy and safety. Two examples of such drugs are selamectin and fipronil. This article allows veterinarians and other readers to compare the safety and efficacy of these drugs before administering them to their patients.
Amir, K. L., I Gusti, M. K. E., I Putu G. Y. A. (2020). Laporan Kasus: Pemberian Terapi Ivermectin dan Sulfur terhadap Kasus Scabiosis pada Kucing Ras Persia. Indonesia Medicus Veterinus, 9 (1): 89-98
Becskei, C., Lin, D., Rugg, D., Geurden, T. (2017). Speed of kill of a new spot-on formulation of selamectin plus sarolaner for cats against induced infestations with Ixodes ricinus. Vet Parasitol, 238 Suppl 1:S8-S11.
Becskei C., Cherni J. A., Vatta A. F., King V. L., Lin D., Rugg D. (2017). Efficacy And Speed Of Kill Of A New Spot-On Formulation Of Selamectin Plus Sarolaner Against Flea Infestations In Cats. Veterinary Parasitology. Volume 238. Supplement 1. Pages S18-S21.
Bilwal, A. K., V. L Paramar., N. N Brahmbhatt., A. A. Vagh., A. A. Vasava. (2020). Clinical presentation and therapeutic management of ivermectin toxicity in German Spitz dog. Journal of Entomology and Zoology Studies, 8(1): 1155-1157.
Bonneau, S., Gupta, S., Cadiergues, M.C. (2010). Comparative efficacy of two fipronil spot-on formulations against experimental tick infestations (Ixodes ricinus) in dogs. Parasitol Res,107(3):735-9.
Bouhsira ., FrancM., LienardE., Bouillin C., Gandoin C., Geurden T., Becskei C., Jacquiet P., Thomas A., Boulouis H. J. (2015). The Efficacy Of A Selamectin (Stronghold®) Spot On Treatment In The Prevention Of Bartonella Henselae Transmission By Ctenocephalides Felis In Cats, Using A New High-Challenge Model. Parasitology Research Volume 114. Pages 1045-1050.
Bowman. D. D., Satomi, K., Elizabeth, A. F. (2001). Effects of an Ivermectin Otic Suspension on Egg Hatching of the Cat Ear Mite, Otodectes cynotis, in Vitro. Veterinary Therapeutics, 2 (4)
Boy, M.G., Six, R.H., Thomas, C.A., Novotny, M.J., Smothers, C.D., Rowan, T.G., Jernigan, A.D. (2000). Efficacy and safety of selamectin against fleas and heartworms in dogs and cats presented as veterinary patients in North America. Vet Parasitol, 23;91(3-4):233-50.
Canga. A. G., Nélida, F. M., Ana. S. P., Juan, G. V., María, J. D. L., Pedro, P. T. M., Matilde, S. V. (2010). Safety of ivermectin: toxicity and adverse reactions in several mammal species. Rev.MVZ Córdoba, 15(2):2127-2135.
Canga. A. G., Ana. S. P., M. Jose ´ Diez, L., Ne ´lida, F. M., Matilde, S. V., Juan, J. G. V. (2009) The pharmacokinetics and metabolism of ivermectin in domestic animal species. The Veterinary Journal, 179: 25–37
Carol, M., McNair. (2015). Ectoparasites of medical and veterinary importance: drug resistance and the need for alternative control methods. Royal Pharmaceutical Society, Journal of Pharmacy and Pharmacology, 67, pp. 351–363
Dong, Z., Shou-ye, X., Ji-yu, Z., Xu-zhen, Z. (2020). 14-Day Toxicity of Ivermectin Microemulsion. Frontiers in Veterinary Science, 7: 598313
Dryden, M.W., Payne, P.A., Smith, V., Berg, T.C., Lane, M. (2013). Efficacy of selamectin, spinosad, and spinosad/milbemycin oxime against the KS1 Ctenocephalides felis flea strain infesting dogs. Parasit Vectors, 25;6:80.
Dryden, M.W, Payne, P.A, Vicki, S., Riggs, B., Davenport, J., Kobuszewski, D. (2015). Efficacy of dinotefuran-pyriproxyfen, dinotefuran-pyriproxyfen-permethrin and fipronil-(S)-methoprene topical spot-on formulations to control flea populations in naturally infested pets and private residences in Tampa, FL. Vet Parasitol,15;182(2-4):281-6.
Eiden A. L., Kaufman P. E., OI F. M., Allan S. A., Miller R. J. (2015). Detection of Permethrin Resistance and Fipronil Tolerance in Rhipicephalus sanguineus (Acari: Ixodidae) in the United States. Journal of Medical Entomology. Volume 52. Issue 3. Pages 429–436.
El-Saber Batiha, G., Alqahtani, A., Ilesanmi, O.B., Saati, A.A., El-Mleeh, A., Hetta, H.F., Magdy Beshbishy, A.(2020).Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. Pharmaceuticals 2020, 13, 196.
Fankhauser, B., Dumont, P., Hunter, J.S., McCall, J.W., Kaufmann, C., Mathis, A, Young, D.R, Carroll, S.P., McCall, S., Chester, S.T., Soll, M.D. (2015). Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs. Parasit Vectors, 30;8:64.
Farmaki, R., Simou, C., Papadopoulos, E., Koutinas, A.F, Saridomichelakis, M.N.(2013). Effectiveness of a single application of 0·25% fipronil solution for the treatment of hirstiellosis in captive green iguanas (Iguana iguana): an open-label study. Parasitology. 140(9):1144-8.
Fauziyah, S., Abdul, H. F., Norma, F. F., Adi, P., Pradika, G. B., Lensa, R. S., Zukhaila, S. (2020). Ectoparasite Infestation among Stray Cats around Surabaya Traditional Market, Indonesia. Journal of Tropical Biodiversity and Biotechnology, 05, (3): 201- 210
Gant, D. B., Chalmers, A. E., Wolff, M. A., Hoffman, H. B., Bushey, D. F. (1998). Fipronil: action at the GABA receptor.Pesticides and the future: minimizing chronic exposure of humans and the environment. pp.147-156 ref.27.
Geurden, T., Becskei, C., Vatta, A.F., Slootmans, N., von Reitzenstein, M., King, V.L., Lin, D., Rugg, D. (2017). Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe. Vet Parasitol, 238 Suppl 1:S3-S7.
Geurden, T., Becskei, C., Farkas, R., Lin, D., Rugg, D. (2017). Efficacy And Safety Of A New Spot-On Formulation Of Selamectin Plus Sarolaner In The Treatment Of Naturally Occurring Flea And Tick Infestations In Cats Presented As Veterinary Patients In Europe. Veterinary Parasitology. Volume 238, Supplement 1. Pages S12-S17.
Hany, E. (2017). Ectoparasites: preventive plans and innovations in treatment. Vet Times The website for the veterinary profession https://www.vettimes.co.uk.
Hill, P. B., A. Lo., C. A. N. Eden., S. Huntley., V. Morey., S. Ramsey., C. Richardson.,
D. J. Smith., C. Sutton., M. D. Taylor., E. Thorpe., R. Tidmarsh., V. Williams. (2006). Survey of the prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice
Jadhav, R.K and A.U. Bhikane.(2020). Ivermectin toxicity in American Pit Bull Terrier bitch and its therapeutic management. The Indian Veterinary Journal. Med, 40 (1) : pp. 48-51
Jourdan, G., Guillaume, B., Isabelle, R. L., Emilie, B., Benjamin, B., Patrick, V. (2015). Intravenous lipid emulsion therapy in 20 cats accidentally overdosed with ivermectin. Journal of Veterinary Emergency and Critical Care, 25(5): pp 667–671
Kumar, K.S., P. Selvara., S. Vairamuthu., S.R. Srinivasan., D. Kathiresan. (2008). Ivermectin Therapy In the Management Of Notoedric Mange In Cats. Tamilnadu J. Veterinary & Animal Sciences, 4 (6) 240-241
Magalhí£es, H. K. N. M., Lúcia, F. L.S., Ana, K.R.M. L., Wesley, L. C. R. Bruna, P. C. Intoxicaçí£o por ivermectina em gato - Relato de caso. (2015). Brazilian Journal of Hygiene and Animmal Sanity, 9(1): 69-77
Mohsen, E. M. A., El Maghraby, N. M., Salama, A. A., Abdlmonem, A. S., Authman, E. A., Abdelmohsen, E. A., Eltras, M. A. E., Barseem, O. N., Awad, S. R., Matter, A. A., Abo, S. A. M., Elgozier, E. A., Elnagar, M. A., El Bialy, B. E. S., El Borai, N. B. (2019). Protective effects of vitamin E and grape seed oil against acute hepatorenal ivermectin toxicity in mice: biochemical and histopathological studies. GSC Biological and Pharmaceutical Sciences, 07(02): 087–094
Muhammad, G., Jabbar, A., Khan, M.Z., Saqib, M. (2004). Use of Neostigmine in Massive Ivermectin Toxicity in Cats. Vet Human Toxicol. 46 (1)
McTier, TL., Hair, J.A., Walstrom, D.J., Thompson, L. (2003). Efficacy and safety of topical administration of selamectin for treatment of ear mite infestation in rabbits. J Am Vet Med Assoc. 223(3):322-4.
Nasution, A. Y. A. Upik, K. H., Elok, B. R. (2018) Prevalence of ectoparasites and endoparasites on companion dogs which visit animal clinic at north Jakarta. Journal of Entomology and Zoology Studies, 6(4): 1099-1104
Oh, T. H., Oh, W. S., Kim, S. R., Oh, H. Y., Hoh, W. P., Jeong, A. Y., Jeong, H. H., Park, S. J. (2004). Efficacy Of Selamectin In Canine Scabies And Ear Mite Infestation In Korea. First Veterinary Dermatology Volume15, Issues1, Pages 48-48.
Olivieri, L., Nardini, G., Leopardi, S., & Abramo, F. (2015). Mite Infection In A Masked Palm Civet (Paguma Larvata) Treated By Selamectin (Stronghold®, Pfizer Ltd.). Journal Of Zoo And Wildlife Medicine, 46(3), 592-595.
Page, N., Caroline, J., Manon, P. (2000). Observations on topical ivermectin in the treatment of otoacariosis, cheyletiellosis, and toxocariosis in cats. The Canadian veterinary journal, 41:773-776
Panwar, N., Kumar, A. (2011). Efficacy Of Sekamectin And Fipronil Against Ctenocephalides Canis. Journal Of Experimental Zoology, India. Vol.14 No.1 Pp.209-211 Ref.19.
Paterson. T. E., Richard ,E. H., Paul. J. F., Marta L. L., Geoff, B., Jakobus, L., Rhonda, P. (2014). Canine generalized demodicosis treated with varying doses of a 2.5% moxidectin + 10% imidacloprid spot-on and oral ivermectin: Parasiticidal effects and long-term treatment outcomes. Veterinary Parsitology.
Perkins R., Whitehead M., Civil W., Goulson D. (2021). Potential Role Of Veterinary Flea Products In Widespread Pesticide Contamination Of English Rivers. Science Of The Total Environment. Vol. 755. Part 1.
Peter, M. D. 2016. Therapeutic Review: Selamectin. Journal Of Exotic Pet Medicine 25 (2016), Pp 80–83.
Poché, D.M, Torres-Poché, Z., Yeszhanov, A., Poché, R.M., Belyaev, A., DvoÅ™ák, V., Sayakova, Z., Polyakova, L., Aimakhanov, B. (2018). Field evaluation of a 0.005% fipronil bait, orally administered to Rhombomys opimus, for control of fleas (Siphonaptera: Pulicidae) and phlebotomine sand flies (Diptera: Psychodidae) in the Central Asian Republic of Kazakhstan. PLoS Negl Trop Dis, 25;12(7).
Purnamaningsing, H., Ida, T. (2002). Efektivitas Ivermectin dan Fipronil dalam Mengatasi Serangan Caplak pada Anjing. Jurnal Sain Veteriner. 20 (1)
Qureshi, S. Biochemical Toxicity of Ivermectin in Wistar Albino Rats. (2013). American-Eurasian Journal of Toxicological Sciences, 5 (1): 15-19.
Ramesh, C., Gupta. (2018). Chapter 42 - Fipronil, Editor(s): Ramesh C. Gupta,Veterinary Toxicology (Third Edition),pp 533-538. ISBN 9780128114117.
Rohdich, N., Zschiesche, E., Wolf, O., Loehlein, W., Pobel, T., Gil, M.J, Roepke, R.K.A. (2018). Field effectiveness and safety of fluralaner plus moxidectin (Bravecto® Plus) against ticks and fleas: a European randomized, blinded, multicenter field study in naturally-infested client-owned cats. Parasit Vectors, 19;11(1):598.
Saqib, M., Ghazanfa, A., Mudassar, N. M. (2015). Successful management of ivermectininduced blindness in an African lion (Panthera leo) by intravenous administration of a lipid emulsion. BMC Veterinary Research 11:287
Schenker,R., Tinembart, O., Humbert-Droz,E., Cavaliero, T.,Yerly, B. (2003). Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs,Veterinary Parasitology,112 (3) : 249-254.
Shanks, D.J., McTier, T.L., Behan, S., Pengo, G., Genchi, C., Bowman, D.D., Holbert, M.S., Smith, D.G., Jernigan, A.D., Rowan, T.G. (2000). The efficacy of selamectin in the treatment of naturally acquired infestations of sarcoptes scabiei on dogs. Vet Parasitol, 23;91(3-4):269-81.
Shiveraw, S. (2018). An Overview of Ectoparasites on Domestic Animals in Ethiopia. Journal Veter Sci Med. 2018;6(1): 5
Sidhu. S., Asmita, N., Kirti, D., Neetu, S. (2019). Successful management of ivermectin toxicity in a Persian cat. The Indian Veterinary Journal, 39 (1) pp. 59-60
Simon, M. S., A. Methai., N. Pazhanivel., K. Krishnakumar. Intralipids for the Management of Ivermectin Toxicity in a Dog. 2019. The Indian Veterinary Journal, 96 (11) : 68 – 69
Six, R.H., Clemence, R.G, Thomas, C.A, Behan S., Boy, M.G., Watson, P., Benchaoui, H.A., Clements, P.J., Rowan, T.G., Jernigan, A.D. (2000). Efficacy and safety of selamectin against Sarcoptes scabiei on dogs and Otodectes cynotis on dogs and cats presented as veterinary patients. Vet Parasitol, 23;91(3-4):291-309.
Timur, N. P. V. T., Putu, A. P, I Ketut, P. (2015). Prevalence of Skin Disorders in Kintamani Dog Prevalensi Gangguan Kulit pada Anjing Kintamani. Jurnal Ilmu dan Kesehatan Hewan, Februari, 3 (1) : 5-9
Tripathi, A.K and J.S. Soodan. (2012). Ivermectin Toxicity in Pomeranian Pup- A Case Report. The North-East Veterinarian, 12 (1)
Tüzer E., Muz M. N., Bilgin Z., Erçin S., Tinar R. (2010). Fipronil Damlatma Çözeltisinin Kedi Ve Köpeklerde Pirelere Ve Köpeklerde Kenelere Etkisi. Kafkas Univ Vet Fak Derg Research Article16 (3): 469-472.
Waleed, M. S. (2010). Clinical and Histopathological Investigation of Ivermectin Toxicity In Pigeons. Bas.J.Vet.Res, 9(1).
Yanuartono., S. Indarjulianto., A. Nururrozi., S. Raharjo., H. Purnamaningsih. (2020) Penggunaan Antiparasit Ivermectin pada Ternak: Antara Manfaat dan Risiko. Jurnal Sain Peternakan Indonesia, 15 (1)
Yonetake, W., Fujii, T., Naito, M., Hodge, A., Maeder, S., Rugg, D. (2019). Efficacy of a new topical formulation of selamectin plus sarolaner for the control of fleas and ticks infesting cats in Japan. Vet Parasitol, 270 Suppl 1:S12-S18.
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