New vesicovaginal fistula formation in a rabbit model

Eighty M Kurniawati, Tri HS Hadi, Nur AR Widiatmoko, Widjiati Widjiati, Fedik A Rantam, Budi Santoso, Budi I Santoso, Hari Paraton, Gatut Hardianto, Azami D Azinar, Boedi Setiawan

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Objective: To create an animal model of vesicovaginal fistula as a modality to develop therapy.

Material and Methods: This study was an preliminary experimental study to create new fistula vesicovaginal formation in a rabbit model. Six female New Zealand white rabbits of Stem Cell Research and Development Center of Universitas Airlangga were used in this study and were divided into 3 groups in which there were 2 rabbits in each group. Vesicovaginal fistula formation was performed through laparotomy surgery. After the abdomen is opened, the Nasogastric tube is inserted vaginally into the anterior vaginal wall. The incision is made on the anterior vaginal wall and the posterior wall of the bladder. The Nasogastric tube that comes out of the vagina is inserted into the bladder incision to maintain the formation of vesicovaginal fistula. Both mucosal walls are sutured and tested to determine if there is any leak. Evaluation the model of vesicovaginal fistula was carried out 3 weeks postoperatively according the group.

Result: Four out of six rabbits have formed vesicovaginal fistulas, which are from groups two and three. There are no complications during the treatment period until termination

Conclusion: Rabbits have the potential to become experimental animals for the vesicovaginal fistula model. The best time to release a nasogastric tube to maintain a fistula is 2 weeks.


vesicovaginal fistula; animal model

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Stamatakos M, Sargedi C, Stasinou T, Kontzoglou K. Vesicovaginal Fistula: Diagnosis and Management. Indian J Surg. 2014;76(2):131-136. doi:10.1007/s12262-012-0787-y

Diallo AB, Oury Diallo TM, Bah I, et al. Vesicovaginal Fistulas: Anatomical Clinical and Surgical Aspects in the Conakry University Hospital Center. Open J Urol. 2015;05(12):224-230. doi:10.4236/oju.2015.512036

Yuh LM, Rothschild JG. Complications and Long-Term Sequelae of Bladder Fistula Repair. Curr Bladder Dysfunct Rep. 2016;11(4):317-324. doi:10.1007/s11884-016-0398-8

Javed A, Abdullah A, Faruqui N, Syed SS, Binat-Ul-Mehdi, Pirzada AJ. Doctor!will I be dry? Factors determining recurrence after vesicovaginal fistula repair. J Pak Med Assoc. 2015;65(9):954-958.

Quesenberry KE, Carpenter JW. FERRETS, RABBITS, and RODENTS Clinical Medicine and Surgery. Third. Elsevier Inc.; 2012.

Hawk CT, Leary SL, Morris TH. FORMULARY FOR LABORATORY ANIMALS. third. Blackwell Publishing; 2005.

Meeks GR, Sams IV JO, Field KW, Fulp KS, Margolis MT, Schneider GT. Formation of vesicovaginal fistula: The role of suture placement into the bladder during closure of the vaginal cuff after transabdominal hysterectomy. Am J Obstet Gynecol. 1997;177(6):1298-1304. doi:10.1016/S0002-9378(97)70068-1

Lindberg J, Rickardsson E, Andersen M, Lund L. Formation of a vesicovaginal fistula in a pig model. Res Reports Urol. 2015;7:113-116. doi:10.2147/RRU.S72119

Abramov Y, Golden B, Sullivan M, et al. Histologic characterization of vaginal vs. abdominal surgical wound healing in a rabbit model. Wound Repair Regen. 2007;15(1):80-86. doi:10.1111/j.1524-475X.2006.00188.x


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