Penurunan progesterone-induced blocking factor (PIBF) sebagai penanda preeklampsia

Achmad Salman, Budi Wicaksono, Erry Gumilar Dachlan, Widjiati Widjiati

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Background: Pathogenesis of preeclampsia still a controversial research objects. Progesterone induced blocking factor has protective effects in pregnancy.

Objectives: To compare PIBF serum level and placental weight and investigate correlation between both in preeclampsia.

Methods: This experimental study used 16 Mus musculus with normal pregnancy and 16 Mus musculus that were injected with anti Qa-2 to create a preeclampsia model. Terminations of were performed in day 16th, followed by ELISA examination for PIBF serum level and placental weight measurement.

Result: PIBF serum level significantly reduced on preeclampsia model  compared with control (33,21±29,36 ng/ml vs 105,76±59,69 ng/ml; p<0,05). There was no different of placental weight in preeclampsia model compared with control (97,75±50,74 mg vs 116,09±44,45 mg; p>0,05). There was no significant correlation between PIBF serum level and placental weight.

Conclusion: Decreased of PIBF serum level could be used as a marker of preeclampsia. Decreased of PIBF serum level may be correlate with placental pathology in preeclampsia.


Preeclampsia, PIBF, placental weight, Mus musculus, model preeclampsia

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