Efek Pemberian Lactobacillus plantarum IS-10506 terhadap Indeks Scoring Atopic Dermatitis (SCORAD) Pasien Dermatitis Atopik Dewasa Derajat Ringan-Sedang: Uji Klinis Acak Terkontrol, Tersamar Ganda
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Latar belakang: Efek terapi probiotik pada dermatitis atopik (DA) telah dibuktikan, namun hanya beberapa studi pada populasi dewasa dan hasilnya masih tidak konsisten. Ketidakseimbangan sel T-helper (Th)1 dan Th2 diduga memengaruhi kadar imunoglobulin (Ig) E, yang juga memengaruhi indeks Scoring Atopic Dermatitis (SCORAD). Penatalaksanaan standar yang telah ada hanya mengurangi gejala DA. Lactobacillus plantarum (LP) IS-10506 merupakan probiotik yang diisolasi dari dadih, suatu fermentasi susu kerbau tradisional asli Indonesia yang diharapkan akan memperbaiki gejala DA karena efek imunomodulator. Tujuan: Mengevaluasi perbaikan indeks SCORAD setelah pemberian LP IS-10506 pada DA dewasa derajat ringan-sedang. Metode: Uji klinis acak terkontrol tersamar ganda terhadap 30 pasien DA dewasa derajat ringan-sedang dirandomisasi untuk mendapatkan LP (dosis: 2x1010 cfu/hari) atau plasebo selama 8 minggu di Divisi Alergi Imunologi Instalasi Rawat Jalan (IRJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Indeks SCORAD dievaluasi sebelum, minggu ke-4, dan sesudah intervensi (minggu ke-8). Hasil: Sebesar 15 sampel pada kelompok LP dan 15 sampel pada kelompok plasebo dapat menyelesaikan studi. Nilai SCORAD pada kelompok LP lebih rendah dibanding plasebo dengan rerata selisih yang berbeda bermakna pada minggu ke-4 (p = 0,040) dan minggu ke-8 (p = 0,022). Simpulan: Pemberian LP IS-10506 dapat dipertimbangkan sebagai terapi tambahan pada DA dewasa derajat ringan-sedang karena memiliki efek imunomodulator.
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