The Influence of Psychocurative on Cortisol Level, Anxiety, and Quality of Life in Advanced Stage Cervical Cancer Patients

Soetrisno Soetrisno, Sri Mulyani, Hafi Nurinasari, Hafi Nurinasari, Erindra Budi

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Every year, there are 500.000 new cases and more than 250.000 deaths caused by cervical cancerworldwide. Cervical cancer patients faced physical and psychological problems several times that it activate stress mechanism such as hypothalamus-pituitary-adrenal (HPA) axis. These recurrent activations caused HPA axis disruption and adverse clinical effects. Several symptoms of endocrine stress response are the change of circadian cortisol rhythm. Cortisol is known as a stress hormone that involves an organism's response to stress and anxiety that influence the quality of life. This research aims to analyze the differences among serum cortisol level, anxiety, and quality of life in cervical cancer patients before and after psychocurative intervention in obstetrics and gynecology wards and polyclinic in RSUD Dr. Moewardi Surakarta. This research is an experimental double-blind randomized controlled clinical trial pre-test post-test group design study. The subjects were advance stage (IIB-IV)cervical cancer patients. The subjects were randomly chosen into fifteen subjects that given standard therapy and psychocurative, while the other fifteen subjects as a control only got standard therapy. Data were obtained from measurement of serum cortisol level, anxiety questionnaire DASS 42 and WHO quality of life questionnaire. Data were analyzed using SPSS 21 using difference test. The difference mean test result of cortisol serum level, anxiety, quality of life from the controlled group and uncontrolled group showed a significant difference (p < 0.05). In conclusion, psychocurative is significant to reduce cortisol level, anxiety, and improve the quality of life in advanced stage cervical cancer patients.


Psychocurative; cortisol; anxiety; quality of life

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in cervical cancer survivors. Acta Medica Marisiensis 58, 275-277

American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorder. 5th Ed. Virginia, American Psychiatric Publishing, p 155-158

Andrijono (2007). Kanker serviks. Jakarta, Balai Penerbit Fakultas Kedokteran Universitas Indonesia

Azis MF (2009). Gynecological cancer in Indonesia, J Gynecol Oncol 20, 8-10

Bastaman HD (2007). Logoterapi: Psikologi untuk menemukan makna hidup dan meraih hidup bermakna. 1st Ed. Jakarta, PT Raja Grafindo Persada

Himpunan Onkologi Ginekologi Indonesia (2013). Panduan pelayanan klinik kanker ginekologi. Jakarta, Himpunan Onkologi Ginekologi Indonesia

Kang KA, Im JI, Kim HS, et al (2009). The effect of logotherapy on the suffering,finding meaning, and spiritual well-being of adolescents with terminal cancer. JKorean Acad Child Health Nus 15, 136-144

King CR, Hinds PS (2012). Quality of life: From nursing and patient perspectives. United Kingdom, Jones and Barlett Publishers

Lovallo WR, Farag NH, Vincent AS, et el (2006). Cortisol responses to mental stres, exercise, and meals following caffeine intake in men and women. Pharmacology Biochemistry and Be-haviour 83, 441-447

Martha M (2006). Effect of spirituality in breast cancer survivors. Oncology Nursing Forum 33, E1-E7

Murti B (2010). Desain dan ukuran sampel untuk penelitian kuantitatif dan kualitatif di bidang kesehatan. Yogyakarta, Gajah Mada University Press

Rasjidi I (2009). Epidemiologi kanker serviks. Indonesian Journal of Cancer 3, 108

Schettler T (2013). The ecology of breast cancer: The promise of preventionand the hope for healing. Stres, Social Support, and Breast Cancer, 145-162

Sephton SE, Sapolsky RM, Kraemer HC, et al (2000). Diurnal cortisol rhythm as a predictor of breast cancer survival. J Natl Cancer Inst. 92, 994-1000.

Stone AA, Schwartz JE, Smyth J, et al (2001). Individual differences in the diurnal cycle of salivary free cortisol: A replication of flattened cycles for some individuals. Psychoneuroendocrinology 26, 295-306

Soetrisno (2009). Ekspresi Heat shock Protein60,70,90 dan kortisol pada persalinan ibu primigravida yang mendapat psikokuratif. A dissertation. Surabaya, Universitas Airlangga

Young AH (2004). Cortisol in mood disorders. Stress 7, 205-8


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