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Abstract
Highlight:
- Profile of skin biopsy results which carried out the anatomical pathology examination was reviewed.
- The highest skin biopsy disease group case are erythropapulosquamous, infection, skin tumor, vesiculobullous, connective tissue disease, pigmentation disorders, and vasculitis
Abstract:
Skin biopsy is an important tool used by dermatologists in diagnostic determination. The correlation between clinical and histological features is needed in understanding pathogenesis and formulating the diagnosis of a skin disease with a greatly varied spectrum of histopathological results, while the observable clinical symptoms are highly limited. Skin diseases are still a serious problem worldwide, especially in Indonesia. Based on the Indonesian Health Profile in 2010, skin diseases ranked third out of 10 most diseases in outpatients in hospitals throughout Indonesia. This study was a review of the profile of skin biopsy results in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from 1 July 2014 to 31 July 2019, which were subjected to anatomic pathology examination. This study was an observational descriptive study using secondary data sources from the medical records at the Communication and Information Technology Installation (ICT) of Dr. Soetomo General Academic Hospital, Surabaya. Based on data searches, the total number of biopsy examinations performed was 1,368 cases. There were more female patients (50.3%) than males (49.7%). The most common skin disorder found was erythropapulosquamous disorder (30%), followed by infection (18%). Other cases consisted of skin tumor (15%), vesiculobullous (13%), connective tissue disease (7%), pigmentation disorders (5%), and vasculitis (5%). Diseases that could not be classified into 7 groups of the biopsy criteria were grouped separately in other diseases (7%).
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References
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- Alviariza A, Widyawati S (2020). Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019. Bali Dermatology Venerol. J 3, 52–54.
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- Apalla Z, Lallas A, Sotiriou E, (2017). Epidemiological trends in skin cancer. Dermatol. Pract. Concept 7, 1–6.
- Arundhati S, Ragunatha S, Mahadeva K (2013). A cross-sectional study of clinical, histopathological and direct immunofluorescence spectrum of vesiculobullous disorders. J. Clin. Diagnostic Res 7, 2788–2792.
- Costa G, Bharambe B (2010). Spectrum of non-infectious erythematous, papular and squamous lesions of the skin. Indian J. Dermatol 55, 225–228.
- Glinkova V, Shevah O, Boaz M, et al (2004). Hepatic haemangiomas: possible association with female sex hormones. Gut 53, 1352–1355.
- Goldsmith L, Katz S, Gilchrest B, et al (2012). Fitzpatrick's dermatology in general medicine. 8th ed. McGraw-Hill, New York.
- Gottschalk P, Vasquez R, Lopez P, et al (2014). Scleroderma in the Caribbean: Characteristics in a dominican case series. Reumatol. Clin 10, 373–379.
- Greenberg R, Skornick Y, Kaplan O (1998). Management of breast fibroadenomas. J. Gen. Intern. Med 13, 640–645.
- Gupta S, Handa S, Kanwar A, et al (2009). Cutaneous vasculitides: Clinico-pathological correlation. Indian J Dermatol Venerol Leprol 75, 356–362.
- Hosamane S, Pai M, Philipose T, et al (2016). Clinicopathological study of non-infectious erythematous papulosquamous skin diseases. J. Clin. Diagnostic Res 10, 19–22.
- James W, Elston D, Berger T (2015). Andrews' diseases of the skin: Clinical dermatology. 12th ed. Elsevier, London.
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- Jha S, Mendez M (2021). Café au lait macules. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
- Johnson D, Voorhees R, Lufkin R (1983). Cholesteatomas of the temporal bone: Role of CT. Radiology 148, 733–737.
- Khumar A, Shrestha P, Pun J, et al (2015). Profile of skin biopsies and patterns of skin cancer in a tertiary care center of Western Nepal. Asian Pacific J. Cancer Prev 16, 3403–3406.
- Klein S (2012). Immune cells have sex and so should journal articles. Endocrinology 153, 2544–2550.
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- Odonwodo A, Badri T, Hariz A (2021). Scleroderma. Available from https://www.ncbi.nlm.nih.gov/.
- Fol Med Indones, Vol. 58 No. 1 March 2022: 372-380 Asnar et al: Profile of Skin Biopsy Patients in Dr.Soetomo
- Accessed 14 January, 2022.
- Oliver J, Silman A (2009). Why are woman predisposed to
- autoimmune rehumatic diseases? Arthritis Res. Ther 11, 1–9.
- Pandey A, Sonthalia S (2021). Skin tags. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
- Robinson P, Hotwagner D (2021). Henoch-schönlein purpura Available from
- https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
- Veldurthy V, Shanmuham C, Sudhir N, et al (2015). Pathological study of non-neoplastic skin lesions by punch biopsy. Int. J. Res. Med. Sci 3, 1985–1988.
- Winfield H, Jaworsky C (2009). Connective tissue disease. In: Lever's Histopathology of the Skin. Philadelphia, Lippincott Williams & Williams, p. 279.
References
Ahmed A, Penhale W, Talal N (1985). Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am. J. Pathol 121, 531–551.
Alviariza A, Widyawati S (2020). Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019. Bali Dermatology Venerol. J 3, 52–54.
Andersen L, Davis M (2017). Sex differences in the incidence of skin and skin-related diseases in olmsted county, Minnesota, United States, and a comparison with other rates published worldwide. Int. J. Dermatol 55, 939–955.
Apalla Z, Lallas A, Sotiriou E, (2017). Epidemiological trends in skin cancer. Dermatol. Pract. Concept 7, 1–6.
Arundhati S, Ragunatha S, Mahadeva K (2013). A cross-sectional study of clinical, histopathological and direct immunofluorescence spectrum of vesiculobullous disorders. J. Clin. Diagnostic Res 7, 2788–2792.
Costa G, Bharambe B (2010). Spectrum of non-infectious erythematous, papular and squamous lesions of the skin. Indian J. Dermatol 55, 225–228.
Glinkova V, Shevah O, Boaz M, et al (2004). Hepatic haemangiomas: possible association with female sex hormones. Gut 53, 1352–1355.
Goldsmith L, Katz S, Gilchrest B, et al (2012). Fitzpatrick's dermatology in general medicine. 8th ed. McGraw-Hill, New York.
Gottschalk P, Vasquez R, Lopez P, et al (2014). Scleroderma in the Caribbean: Characteristics in a dominican case series. Reumatol. Clin 10, 373–379.
Greenberg R, Skornick Y, Kaplan O (1998). Management of breast fibroadenomas. J. Gen. Intern. Med 13, 640–645.
Gupta S, Handa S, Kanwar A, et al (2009). Cutaneous vasculitides: Clinico-pathological correlation. Indian J Dermatol Venerol Leprol 75, 356–362.
Hosamane S, Pai M, Philipose T, et al (2016). Clinicopathological study of non-infectious erythematous papulosquamous skin diseases. J. Clin. Diagnostic Res 10, 19–22.
James W, Elston D, Berger T (2015). Andrews' diseases of the skin: Clinical dermatology. 12th ed. Elsevier, London.
Jan H, Masood S (2021). Vitiligo. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
Jha S, Mendez M (2021). Café au lait macules. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
Johnson D, Voorhees R, Lufkin R (1983). Cholesteatomas of the temporal bone: Role of CT. Radiology 148, 733–737.
Khumar A, Shrestha P, Pun J, et al (2015). Profile of skin biopsies and patterns of skin cancer in a tertiary care center of Western Nepal. Asian Pacific J. Cancer Prev 16, 3403–3406.
Klein S (2012). Immune cells have sex and so should journal articles. Endocrinology 153, 2544–2550.
Lawrence E, Aboud K (2021). Potinflammatory hyperpigmentation. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
Odonwodo A, Badri T, Hariz A (2021). Scleroderma. Available from https://www.ncbi.nlm.nih.gov/.
Fol Med Indones, Vol. 58 No. 1 March 2022: 372-380 Asnar et al: Profile of Skin Biopsy Patients in Dr.Soetomo
Accessed 14 January, 2022.
Oliver J, Silman A (2009). Why are woman predisposed to
autoimmune rehumatic diseases? Arthritis Res. Ther 11, 1–9.
Pandey A, Sonthalia S (2021). Skin tags. Available from https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
Robinson P, Hotwagner D (2021). Henoch-schönlein purpura Available from
https://www.ncbi.nlm.nih.gov/. Accessed January 6, 2022.
Veldurthy V, Shanmuham C, Sudhir N, et al (2015). Pathological study of non-neoplastic skin lesions by punch biopsy. Int. J. Res. Med. Sci 3, 1985–1988.
Winfield H, Jaworsky C (2009). Connective tissue disease. In: Lever's Histopathology of the Skin. Philadelphia, Lippincott Williams & Williams, p. 279.