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Abstract
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- A 28-year-old male suffered chylothorax and mediastinal seminoma.
- The patient received bleomycin, etoposide and cisplatin chemotherapy for the management of mediastinal seminomas but he died beforeundergoing 5th cycle chemotherapy.
Abstract:
Seminoma is a type of germ cell tumor. In this case presentation, a rare primary germ cell tumor was reported in the form of mediastinal seminoma. A 28-year-old man with symptoms of shortness of breath, chest pain, swelling in the right upper extremity, enlarged lymph nodes in the colli region. Thoracic physical examination revealed signs of pleural fluid in the right hemithorax. After obtaining the results of radiological and pathological investigations, a mediastinal mass was obtained, then BEP chemotherapy was given. After 3 cycles of chemotherapy, a partial response was obtained. Patients with mediastinal seminoma treated with BEP base chemotherapy gave a partial response.
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References
- Al Shaarani M, Shackelford RE, Master SR, et al (2019). Plasmablastic lymphoma, a rare entity in bone marrow with unusual immunophenotype and challenging differential diagnosis. Case Reports in Hematology 2010, 1-10.
- Alikhan M, Song JY, Sohani AR, et al (2016). Peripheral T-cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3−/dimCD4+ population by flow cytometry: An important clue to the diagnosis of a Hodgkin lymphoma mimic. Modern Pathology 29, 1173-1182.
- Boujelbene N, Cosinschi A, Boujelbene N, et al (2011). Pure seminoma: A review and update. Radiat Oncol 6, 1-12.
- Cheville JC, Rao S, Iczkowski KA, et al (2000). Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 113, 582-588.
- Friedlander TW, Ryan CJ, Small EJ, et al. (2014). Testicular cancer: Abeloff’s Clinical oncology. Elsevier Ltd, Canada.
- Jameson JL, Kasper DL, Longo LD, et al (2018). Harrison’s principles of internal medicine: 20th edition. Mc Graw Hill Education, New York.
- King JF, Lam JT (2020). A practical approach to diagnosis of B-cell lymphomas with diffuse large cell morphology. Arch Pathol Lab Med 144, 160-167.
- Kriegsmann M, Muley T, Harms A, et al (2015). Differential diagnostic value of CD5 and CD117 expression in thoracic tumors?: A large scale study of 1465 non-small cell lung cancer cases. Diagn Pathol 10, 1-6.
- Light RW, Lee YCG (2016). Pneumothorax, chylothorax, hemothorax and fibrothorax: Sixth edit. Elsevier Inc, Canada.
- Light RW, Lee YCG (2016). Textbook of pleural diseases. CRC Press, Florida.
- Maldonado F, Hawkin F, Daniels C, et al (2009). Pleural fluid characteristic of chylothorax. Mayo Clin Proc 84, 129-133.
- McGrath EE, Blades Z, Anderson PB (2010). Chylothorax: Aetiology, diagnosis and therapeutic options. Respir Med 104, 1-8.
- Nakagawa K, Matsuno Y, Kunitoh H, et al (2005). Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest 128, 140-144.
- Parikh D. Rajesh PB (2018). Chylothorax. Tips tricks thorac surgery. Springer, Switzerland.
- Yao X-D, Hong Y-P, Ye D-W, et al (2012). Primary yolk sac tumor of seminal vesicle: A case report and literature review. World Journal of Surgical Oncology 10, 1-5.
References
Al Shaarani M, Shackelford RE, Master SR, et al (2019). Plasmablastic lymphoma, a rare entity in bone marrow with unusual immunophenotype and challenging differential diagnosis. Case Reports in Hematology 2010, 1-10.
Alikhan M, Song JY, Sohani AR, et al (2016). Peripheral T-cell lymphomas of follicular helper T-cell type frequently display an aberrant CD3−/dimCD4+ population by flow cytometry: An important clue to the diagnosis of a Hodgkin lymphoma mimic. Modern Pathology 29, 1173-1182.
Boujelbene N, Cosinschi A, Boujelbene N, et al (2011). Pure seminoma: A review and update. Radiat Oncol 6, 1-12.
Cheville JC, Rao S, Iczkowski KA, et al (2000). Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 113, 582-588.
Friedlander TW, Ryan CJ, Small EJ, et al. (2014). Testicular cancer: Abeloff’s Clinical oncology. Elsevier Ltd, Canada.
Jameson JL, Kasper DL, Longo LD, et al (2018). Harrison’s principles of internal medicine: 20th edition. Mc Graw Hill Education, New York.
King JF, Lam JT (2020). A practical approach to diagnosis of B-cell lymphomas with diffuse large cell morphology. Arch Pathol Lab Med 144, 160-167.
Kriegsmann M, Muley T, Harms A, et al (2015). Differential diagnostic value of CD5 and CD117 expression in thoracic tumors?: A large scale study of 1465 non-small cell lung cancer cases. Diagn Pathol 10, 1-6.
Light RW, Lee YCG (2016). Pneumothorax, chylothorax, hemothorax and fibrothorax: Sixth edit. Elsevier Inc, Canada.
Light RW, Lee YCG (2016). Textbook of pleural diseases. CRC Press, Florida.
Maldonado F, Hawkin F, Daniels C, et al (2009). Pleural fluid characteristic of chylothorax. Mayo Clin Proc 84, 129-133.
McGrath EE, Blades Z, Anderson PB (2010). Chylothorax: Aetiology, diagnosis and therapeutic options. Respir Med 104, 1-8.
Nakagawa K, Matsuno Y, Kunitoh H, et al (2005). Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest 128, 140-144.
Parikh D. Rajesh PB (2018). Chylothorax. Tips tricks thorac surgery. Springer, Switzerland.
Yao X-D, Hong Y-P, Ye D-W, et al (2012). Primary yolk sac tumor of seminal vesicle: A case report and literature review. World Journal of Surgical Oncology 10, 1-5.