Article Sidebar

Submitted
14 December 2020
Published
5 September 2021
Download
PDF
Statistic
Read Counter : 1229 Download : 1612

Main Article Content

Abstract

This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW (P1), ethanol extract of gemitir flowers (Tagetes erecta L.) 200 (P2), 400 BW (P3), and 800 mg/kgBW (P4). On day 51, the total cholesterol, LDL-C, MDA, and ApoB blood serum levels were checked. The results showed total cholesterol, Low-Density Lipoprotein (LDL), Malondialdehyde (MDA), and Apolipoprotein B (ApoB) given ethanol extract of gemitir flowers 200 and 400 mg/kgBW (P2) had a significant reduction (P < 0.05). Giving ethanol extract of gemitir flower (Tagetes erecta L.) could reduce levels of total cholesterol, LDL, MDA, and Apo B.

Keywords

ApoB LDL marigold flower (Tagetes erecta L) total cholesterol MDA cardiovascular disease

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Kresnapati, I. N. B. A., Khaerunnisa, S., & Safitri, I. (2021). Ethanol Extract of Marigold Flower (Tagetes Erecta L.) Decreases The Total Cholesterol, Low Density Lypoprotein (LDL), Malondialdehyde (MDA), and Apoliprotein B (APOB) on Hyperlipidemia Rat Models. Folia Medica Indonesiana, 57(3), 245–249. https://doi.org/10.20473/fmi.v57i3.23838
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Baskaran G, Salvamani S, Azlan A, et al (2015). Hypocholesterolemic and antiatherosclerotic potential of Basella alba leaf extract in hypercholesterolemia-induced rabbits. Evidence-Based Complementary and Alternative Medicine 2015, 1-8.
  2. Carlos CC (2019). Reactive oxygen species: training, function and oxidative stress. Medicina Legal de Costa Rica 36, 91-100.
  3. Chan J, Karere GM, Cox LA, et al (2015). Animal models of diet-induced Hypercholesterolemia. IntechOpen, Rijeka.
  4. Friesen JA, Rodwell VM (2004). The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases. Genome Biology 5, 1-7.
  5. Fukai T, Ushio-Fukai M (2011). Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxidants & Redox Signaling 15, 1583-1606.
  6. Gopi G, Elumalai A, Jayasri P (2012). A concise review on Tagetes erecta. International Journal of Phytopharmacy Research 3, 16-19.
  7. Itabe H (2009). Oxidative modification of LDL: Its pathological role in atherosclerosis. Clinical Reviews in Allergy & Immunology 37, 4-11.
  8. Jiang W, Guo MH, Hai X (2016). Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat. World Journal of Gastroenterology 22, 10180-10188.
  9. Kulczyński B, Gramza-Michałowska A, Kobus-Cisowska J, et al (2017). The role of carotenoids in the prevention and treatment of cardiovascular disease: Current state of knowledge. Journal of Functional Foods 38, 45-65.
  10. Kusmiati K, Caesarianto W, Afiati F, et al (2019). Effect lutein of marigold flower (Tagetes erecta L.) on decreasing glucose and malondialdehyde levels in Alloxan-induced blood mice. AIP Conference Proceedings 2120, 1-7.
  11. Li P, Jia J, Zhang D, et al (2014). In vitro and in vivo antioxidant activities of a flavonoid isolated from celery (Apium graveolens L. var. dulce). Food & Function 5, 50-56.
  12. Lingzhi X, Fei G, Zengling Y, et al (2016). Discriminant analysis of terrestrial animal fat and oil adulteration in fish oil by infrared spectroscopy. International Journal of Agricultural and Biological Engineering 9, 179-185.
  13. Manzoni AG, Passos DF, da Silva JL, et al (2019). Rutin and curcumin reduce inflammation, triglyceride levels and ADA activity in serum and immune cells in a model of hyperlipidemia. Blood Cells, Molecules, and Diseases 76, 13-21.
  14. Pramitha DAI, Suaniti NM, Sibarani J (2018). Aktivitas antioksidan bunga pacar air merah (Impatiens balsamina L.) dan bunga gemitir (tagates erecta L.) dari limbah canang. Chimica et Natura Acta 6, 8-11.
  15. Pulungan A, Pane YS (2020). The benefit of cinnamon (Cinnamomum burmannii) in lowering total cholesterol levels after consumption of high-fat containing foods in white mice (Mus musculus) models. F1000Research 9, 1-15.
  16. Raghuveer R, Sreeja K, Sindhuri T, et al (2011). Antihyperlipidemic effect of Tagetes erecta in cholesterol fed hyperlipidemic rats. Der Pharmacia Lettre 3, 266-270.
  17. Rane BT, Worlikar PS, Mulkalwar SA, et al (2019). Evaluation of the effect of lycopene on lipid profile, serum antioxidant enzymes and blood sugar level in New Zealand white (NZW) rabbits. International Journal of Basic & Clinical Pharmacology 7, 1-8.
  18. Shattat GF (2014). A review article on hyperlipidemia: Types, treatments and new drug targets. Biomedical & Pharmacology Jurnal 7, 399-409.
  19. Singh UN, Kumar S, Dhakal S (2017). Study of oxidative stress in hypercholesterolemia. Int J Con-temp Med Res 4, 1204-1207.
  20. Siriamornpun S, Kaisoon O, Meeso N (2012). Changes in colour, antioxidant activities and carotenoids (lycopene, β-carotene, lutein) of marigold flower (tagetes erecta L.) resulting from different drying processes. Journal of Functional Foods 4, 757-766.
  21. Treml J, Å mejkal K (2016). Flavonoids as potent scavengers of hydroxyl radicals. Comprehensive Reviews in Food Science and Food Safety 15, 720-738.
  22. World Health Organization (2019). Cardiovascular disease (CVDs). Available from https://www.who.int/. Accessed November 17, 2020.
  23. Yang RL, Shi YH, Hao G, et al (2008). Increasing oxidative stress with progressive hyperlipidemia in human: Relation between malondialdehyde and atherogenic index. Journal of Clinical Biochemistry and Nutrition 43, 154-158.
  24. Yoshida H, Kisugi R (2010). Mechanisms of LDL oxidation. Clinica Chimica Acta 411, 1875-1882.

Most read articles by the same author(s)