Article Sidebar

Submitted
7 January 2021
Accepted
7 January 2021
Published
31 March 2019
Download
PDF
Statistic
Read Counter : 487 Download : 453

Main Article Content

Abstract

Reperforation after gastric perforation repair is a complication which increases the rate of morbidity and mortality in gastric perforation. The lack of ability of the tissue to use oxygen in septic condition causes anaerobic cellular metabolism and furthermore it will cause failure in closing the perforation. The production of anaerobic metabolism is lactic acid which can be measured from the blood. The aim of this study is to determine the cut-off point of blood lactate level as a predictor of reperforation after repairing gastric perforation. Forty-six patients diagnosed as gastric perforation, who were repaired in Dr Soetomo Hospital from October 2014 to October 2015 were recruited as samples. Serum lactate was taken one hour before repairing the perforation. After being repaired, the patients were observed until the 14th day to evaluate whether any reperforation would occur or not . The design of this research was cross-sectional, analytic observational. The data was analyzed using independent t-test and ROC for obtaining the cut-off point as a predictor of the reperforation after the gastric perforation was repaired. There was a significant difference in the mean of lactate level in the group with reperforation compared with that of the non-reperforation group, that is as big as 3.74±0.59 mmol/L and 2.60±0.76 mmol/L. Using ROC curve analysis, there was the cut-off point of lactate level for reperforation 3.35 mmol/L, with sensitivity 92.9%, specificity 84.4%, positive predictive value 72% and negative predictive Value 96.4%, accuracy 87.0% and in the AUC value 0.902.

Keywords

Lactate reperforation of gastric repair cut-off point

Article Details

License

Copyright (c) 2019 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Budipramana, V. S. (2019). Lactate Level as a Prediction Factor of Reperforation after Repairing Gastric Perforation. Folia Medica Indonesiana, 55(1), 43–47. https://doi.org/10.20473/fmi.v55i1.24386
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Bakker J, Schieveld SJ, Brinkert W (2000). Serum lactate level as an indicator of tissue hypoxia in severely ill patients. Ned Tijdschr Geneeskd; 144:377–83.)
  2. Cellan-Jones CJ (1929): A rapid method of treatment in perforated duodenal ulcer. BMJ ; 1076–1077.
  3. Chung K, Vishalkumar G (2017), Perforated peptic ulcer - an update, World J Gastrointest Surg; 27; 9(1): 1-12
  4. Glatter RD, Winters ME.(2009), What is the Clinical Utility of Obtaining Serum Lactate and Arterial Base Deficit Values in Patients with Early Signs of Sepsis and Septic Shock? Medscape.
  5. Hemmat M, Alireza (2011), Generalized Peritonitis Requiring Re-operation After Leakage of Omental Patch Repair of Perforated Peptic Ulcer, Saudi J Gastroenterol. 17(2): 124–128.
  6. Hirst NA, Tiernan J, Millner P (2013), Systematic review of methods to predict and detect anastomotic leakage in colorectal surgery, Colorectal Disease, 16, 95–109
  7. Howard Y, Julie B, Ash A, et all,(2004) Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression Similarities between Tumors and Wounds, Plos Biology, | Volume 2 | Issue 2 | Page 0206
  8. Hyman N, Cataldo O, Burns E, Shackford S. (2009) Anastomotic Leaks after Bowel Resection: What does Peer Review Teach us about the Relationship to Postoperative Mortality? J Am Coll Surg J; 208(1):48-52.
  9. Lee S, Suk An W (2016), New clinical criteria for septic shock: serum lactate level as new emerging vital sign, J Thorac Dis; 8(7):1388-1390.
  10. Marií«tta J. Bertleff J. Lange B (2010), Perforated Peptic Ulcer Disease: A Review of History and Treatment, Dig Surg ; 27:161–169
  11. Marik PE, Bellomo R.(2013); Lactate Clearance as a Target of Therapy in Sepsis: A Flawed Paradigm. OA Crit Care Mar 2013;01;1(1):3
  12. Mí¸ller, Hylander M (2008), Sepsis in patients with peptic ulcer perforation ” An identification of risk factors in patients surgically treated for peptic ulcer perforation: 12AP3-4, European Journal of Anaesthesiology: Volume 25 - Issue - p 170
  13. Molnar J, Mary J, Clark W (2014), Nutrition and Chronic Wounds, Advances in Wound Care, VOLUME 3, NUMBER 11 j 663
  14. Sommer K, Sander A, Albig M (2013), Delayed Wound Repair in Sepsis Is Associated with Reduced Local Pro-Inflammatory Cytokine Expression, PLOS ONE | Volume 8 | Issue 9
  15. Su M, Won S (2016), New clinical criteria for septic shock: serum lactate level as new emerging vital sign, J Thorac Dis; 8(7):1388-1390
  16. Tanguy M, Seguin P, Yannick M (2007), Bench-to-bedside review: Routine postoperative use of the nasogastric tube – utility or futility? , Critical Care, 11:201
  17. Thomas H, Cathy B,(2011) Checklist for Factors Affecting Wound Healing Advances in Skin & Wound Care: Volume 24 - Issue 4 - p 192
  18. Vikram Kate (2018), Intestinal Anastomosis, Medscape Updated.
  19. Wagner O, Egger B.(2003) Influential Factors in Anastomosis Healing. Swiss Surg; 9(3):105-13.