Article Sidebar

Submitted
7 January 2021
Accepted
7 January 2021
Published
31 March 2019
Download
PDF
Statistic
Read Counter : 969 Download : 544

Main Article Content

Abstract

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient's demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

Keywords

Drug allergy treatment outcomes type I hypersensitivity type IV hypersensitivity

Article Details

License

Copyright (c) 2019 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Isyroqiyyah, N. M., Soegiarto, G., & Setiawati, Y. (2019). Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation. Folia Medica Indonesiana, 55(1), 54–57. https://doi.org/10.20473/fmi.v55i1.24387
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Anderson (2008). Gender differences in pharmacological response. International Review of Neurobiology 83, 1-10
  2. Beijer HJ, de Blaey CJ (2002). Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharmacy World & Science 24, 46-54
  3. Cho Y, Yang C. & Chu C (2017). Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): an interplay among drugs, viruses, and immune system. International Journal of Molecular Sciences 18, pii E1243
  4. Darmani EH, Indah T Sy D, Anggraini YE, Makmur O (2016). Gambaran karakteristik pasien erupsi obat alergi di RSUD Arifin Achmad Pekanbaru Periode 2010–2014. Jurnal Ilmu Kedokteran 10, 67-70. Available from https://ejournal.unri.ac.id/index.php/ JIK/article/view/4312/4138. Accessed November 29, 2018]
  5. Dietrich JJ, Quinn JM, England RW (2009). Reasons for outpatient consultation in allergy/immunology. Allergy and Asthma Proceedings 30, 69-74
  6. England RW, Ho TC, Napoli DC, Quinn JM (2003). Inpatient consultation of allergy/immunology in a tertiary care setting. Annals of Allergy Asthma and Immunology 90, 393-397
  7. Gamboa PM (2009). The epidemiology of drug allergy-related consultations in Spanish Allergology Services: Alergológica-2005. Journal of Investigational Allergology and Clinical Immunology 19, 45-50
  8. Mihardja L, Soetrisno U (2012). Prevalence and determinant factors for overweight and obesity and degenerative diseases among young adults in Indonesia. Journal of the ASEAN Federation of Endocrine Societies 27, 77-81
  9. Riedl MA, Casillas AM (2003). Adverse drug reactions: types and treatment options. American Family Physician, 68, 1782-1790
  10. Sasidharanpillai S, Riyaz N, Khader A, Rajan U, Binitha MP, Sureshan DN (2015). Severe cutaneous adverse drug reactions: a clinicoepidemiological study. Indian Journal of Dermatology 60, 102
  11. Shakya R, Rao B, Shrestha B (2004). Incidence of hepatotoxicity due to antitubercular medicines and assessment of risk factors. Annals of Pharmacotherapy 38, 1074-1079
  12. Simons FER, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey FR, El-Gamal YM, Brown SGA, Park HS, Sheikh A (2015). 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organization Journal 8, 32
  13. Solensky R, Khan DA (2010). Drug allergy: an updated practice parameter. Annals of Allergy, Asthma & Immunology 105, 273.e1-273.e78
  14. Thong BYH, Tan TC (2011). Epidemiology and risk factors for drug allergy. British Journal of Clinical Pharmacology 71, 684-700
  15. Thong BYH, Leong KP, Tang CY, Chng HH (2003). Drug allergy in a general hospital: results of a novel prospective inpatient reporting system. Annals of Allergy, Asthma & Immunology 90, 342-347