Article Sidebar

Submitted
7 January 2021
Accepted
8 January 2021
Published
31 December 2019
Download
PDF
Statistic
Read Counter : 855 Download : 477

Main Article Content

Abstract

Multidrug-Resistant Tuberculosis (MDR TB) is caused by an organism that is resistant to at least isoniazid and rifampisin, the two most potent TB drug. Immune response to against Mycobacterum tuberculosis infection is related to the function of immunity. The function of interferon-γ (pro-inflammatory) is to activate macrophages, to stimulate antimicrobial molecules (to reactive oxygen species and nitric oxide), and to inhibits interleukin-10. Interleukin-10 function is to triggers humoral immunity, to inhibit IFN- γ. This study aimed to analyze level changes and the correlation with clinical data, also months of MDR TB patients who received standard OAT therapy. This was an observational study using cross sectional design. There were 29 patients who received standard MDR TB OAT therapy from 1-24 months, who met the inclusion criteria. Then, the patients were divided based on duration of the therapy, which are the initial/intensive and advanced phase. The initial phase divided into 2: first one is for 1-4 months therapy's time (5 patients) and the second one is for more than 4-8 months (6 patients). Then, the advanced group divided into two groups again, which are third group with more than 8-16 months (13 patients) and fouth group with more than 16-24 months (5 patients). Then, measured serum concentration IFN-γ, IL-10 at the start of the study and 4 weeks later with the ELISA method. This research during the period July-December (6 months). IFN-γ post concentrations were decreased by 39.14 ± 139.12 pg/mL (p > 0.05). The concentration of IL-10 was decreased by 33.93 ± 109.20pg/mL (p>0.05). Based on the TB score bandim method during pre and posts results were 1 patient experienced severity change from severity class 1 to 2, 1 patient from severity class 2 to 1, 1 patient remained in severity 2 and 26 patient remained in severity 1. The results showed that serum IFN-γ and IL-10 levels in initial/intensive and advanced phase patients who received MDR TB regiment after four weeks did not changed,

Keywords

IFN-γ IL-10 TB MDR pre-post

Article Details

License

Copyright (c) 2019 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Setyawati, H., Soedarsono, S., Yulistiani, Y., & Fatmawati, U. (2019). Analysis of IFN-gamma and IL-10 Levels as Markers of Inflammation and Response Therapy of Anti-Tuberculosis in MDR Lung TB Patients. Folia Medica Indonesiana, 55(4), 268–274. https://doi.org/10.20473/fmi.v55i4.24394
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Adrian TBR, Montiel JL, Fernandez G, Valecillo A (2015). Role of cytokines and other factors involved in the Mycobacterium tuberculosis infection.. World Journal of Immunology 5, 16-50
  2. Antonio, Lemoa CM, Matos ED (2013). Multidrug-resistant tuberculosis, Spesial article. The Brazilian Journal of Infections Disease 7, 239-246
  3. Baker MA, et al (2011). The impact of diabetes on tuberculosis treatment outcomes: A systematic review. BMC Medicine 9, 1-15
  4. Cavalcanti YVN, Brelaz MCA, Neves JKAL, Ferraz JC, Pereira VRA (2012). Review article: Role of TNF-Alpha, IFN-Gamma, and IL-10 in the development of pulmonary tuberculosis. Pulmonary Medicine 2012, 1-10
  5. Clifford V, et al (2015). Cytokines for monitoring anti-tuberculous therapy: A systematic review. Elsevier XXX, 1-12
  6. Goldsack L, Kirman JR (2007). Half-truths and selective memory: Interferon gamma, CD4(+) T cells and protective memory against tuberculosis. Tuberculosis (Edinb) 87, 465-73
  7. Holtz TH, et al (2006). Time to sputum culture conversion in MDR-TB: Predictor and relationship to treatment ountcome. Annal of Internal Medicine 144, 650-660
  8. Jain SL, et al (2008). Antibiotic treatment of tuberculosis: Old problems. Microbe 3, 285
  9. Khan A, et al 2016. Interferon-Gamma improves macrophages function againts M. Tuberculosis in multidrug-resistant tuberculosis patients. Hindawi 1-10, 2016.
  10. Kinjo Y, et al (2002). Contribution ol IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: A comparative study with IL-12p40. The Journal of Immunolog 169, 323-329
  11. Mase S, Chorba T, Lobue P, Castro K (2013). Provisional CDC guidlines for the use and safety monitoring of bedaquline fumarate (Sirturo) for MDR TB. MMWR 62, 1
  12. Mihardja L, Lolong BD, Ghani L (2015). Prevalensi diabetes melitus pada tuberkulosis dan masalah terapi. Jurnal Ekologi Kesehatan 14, 350-358
  13. Reviono, et al 2014. Multidrug resistant tuberculosis (MDR-TB): Tinjauan epidemiologi dan faktor risiko efek samping obat anti tuberkulosis. MKB 46, 189-196
  14. Shin S, et al (2007). Adverse reactions among patients being trated for MDT-TBin Tomsk, Russia. Int J Tuberc Lung Dis 11, 1314-1320

Most read articles by the same author(s)

1 2 > >>