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Submitted
12 January 2021
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12 January 2021
Published
30 September 2020
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Abstract

The survey results in Indonesia in 2017 showed that the diarrhea morbidity rate for all age groups was 6.897.463. In Indonesia, unripe wooden banana has been used empirically as an antidiarrheal by the people in Senduro village, Lumajang, East Java. The study aimed to prove the antidiarrheal effect of ethanol extract of unripe wooden banana (Musa paradisiaca L) in male Balb-C/mice induced by Escherichia coli bacteria.This study was a laboratory experimental study with post-test only control group design that used 40 micedivided into 8 groups, namely 1group without treatment (normal mice) and 7 groups induced by Escherichia coli(1negative controlgroup given CMC-Na, 3 groups positive controls were given Loperamid HCL 0,5 mg/kgBB, 1 mg/kgBB and 2 mg/kgBB and 3 treatment groups were given extracts 100 mg/kgBB, 200 mg/kgBB and 400 mg/kgBB). Observation of animals in this study was carried out for 4 hours. Data were analyzed of frequency of diarrhea, fecal weight and fecal consistency used Kruskal Wallis and the results showed significant differences between treatment groups (p <0.05). From the results of the Mann-Whitney test, the ethanol extract of unripe wooden banana with a dose of 100 mg/kgBB was notsignificantly different (p> 0.05) with the control group of Loperamid HCL dose of 0.5 mg/kgBB. Unripe wooden banana had been shown to have antidiarrheal activity at an extract dose of 100 mg/kg BB in terms of the parameters of fecal consistency, frequency of diarrhea, and fecal weight. The results showed that the higher the dose, the better antidiarrheal activity

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unripe wooden banana antidiarrheal effect

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How to Cite
Ningsih, A. W., Rochmanti, M., & Basori, A. (2020). Effectiveness of Antidiarrheal Unripe Wooden Banana (Musa paradisiaca L.) in Male Balb-C/Mice Induced with Escherichia coli. Folia Medica Indonesiana, 56(3), 208–215. https://doi.org/10.20473/fmi.v56i3.24558
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References

  1. Fitrahtunnisa O, 2017. Pisang Kayu Sumberdaya Genetik Tanaman Lokal NTB.pp:14-15.
  2. Bagus IG, Ananta T, Rita WS, Oka IM, Parwata A,2018.Potensi ekstrak limbah kulit pisang lokal (Musa sp) sebagai antibakteri terhadap Escherichia coli dan Staphylococcus Aureus.Cakra Kimia, vol:6, no:1,pp:21-29.
  3. Hanani E, 2015. Analisis Fitokimia. Jakarta: Penerbit buku kedokteran EGC.
  4. Alviana N, 2016. Uji Efektivitas Antibakteri Ekstrak Etanol Daun Krisan (Chrysanthemum morifolium Syn. Dendrathema grandiflora) Terhadap Staphylococcus aureus dan Escherichia coli, Skripsi, Universitas Atma Jaya, Yogyakarta.
  5. Suherman LP, Hermanto F, Pramukti ML,2013. Efek antidiare ekstrak etanol daun mindi ( Melia azedarach Linn) pada mencit swiss webster jantan, Kartika Jurnal Ilmiah Farmasi, Des 2013;1(1):38-44.
  6. Dewi IP, 2017.Perbandingan daya antibakteri ekstrak wtanol daun jambu biji (Psidium guajava L) dan ekstrak etanol daun sawo (Manilkara zapota L.) terhadap bakteri Escherichia coli. Jurnal Akademi Farmasi Prayoga. 2017;2(1).
  7. Kemenkes, 2017. Data dan Informasi profil kesehatan Indonesia, Jakarta: Kementrian Kesehatan RI.
  8. Kemenkes, 2017. Profil kesehatan Indonesia tahun 2016, Jakarta : Kementrian Kesehatan RI.
  9. Marbun ED, 2018. Uji efek ekstrak etanol kulit batang kecapi (Sandoricum koetjape Merr) sebagai antidiare yang diinduksi dengan Oleum Ricini dan bakteri Escherichia coli pada marmut jantan, Tesis, Universitas Sumatera Utara, Medan.
  10. Fajrin FA, 2012. Aktivitas antidiare ekstrak etanol daun seledri (Apium graviolens L) pada mencit jantan. PHARMACY, vol.9, No.1.
  11. Ningsih AW, 2010. Uji Efek Antidiare Ekstrak Buah Pisang (Musa Paradisiaca) Pada Mencit (Mus Muculus) Jantan Galur Balb-C, Skripsi, Universitas Jember, Jember.
  12. Ratu AP, Mugiyanto E, 2018. Uji Toksisitas Daun Ketepeng (Cassia Alata L .), Kulit Buah Pisang Ambon (Musa Paradisiaca L . Var Sapientum ) Dan Kulit Rimpang Kencur (Kaempferia Galanga Linn.) Dengan Metode Brine Shrimp Lethality Test ( BSLT ).The 7th University Research Colloqium, STIKES PKU Muhamadiyah Surakarta, PP:189-194.
  13. Rianto L, Handayani IA, Septiyani A, 2015.Uji aktivitas ekstrak etanol 96% biji srikaya (Annona squamosa L.) sebagai antidiare yang disebabkan oleh bakteri S higella dysenteriae dengan metode difusi cakram,Jurnal Ilmiah Manuntung,1(2):181-186.
  14. Dalimartha A setiawan, 2008. Atlas Tumbuhan Obat Indonesia Jilid III. Jakarta: Pustaka Bunda.
  15. Rahmawati I, Fajaryanti N, 2017. Uji aktivitas infusa tanaman anting-anting (Acalyphus australis Linn) sebgai obat diare pada mencit putih (Mus musculus) jantan yang terpapar Oleum Ricini, Jurnal Farmasetis, vol.6, no.1, pp:21-24
  16. Tjay TH, Rahardja K, 2003. Obat-obat penting ed.IV, Jakarta : Departemen Kesehatan RI.
  17. Yu J, Zhang Y, Song X, et al, 2017. Effect of Modified Pulsatilla Powder on Enterotoxigenic Escherichia coli O101-Induced Diarrhea in Mice, Hindawi,pp : 1-11.
  18. Arika F, 2018. Uji aktivitas antidiare ekstrak etanol daun situduh langit (Erigeron Sumatrensis Retz.) terhadaptikus jantan dengan metode transit intestinal,Skripsi, Universitas Sumatera Utara, Medan.
  19. Harborne J, 1987. Metode Fitokimia:Penentuan Cara Modern Menganalisis Tmbuhan. ITB Bandung.
  20. Mufti N, Bahar E, Arisanti D, 2017. Uji Daya Hambat Ekstrak Daun Sawo terhadap Bakteri Escherichia coli secara In Vitro. 6(2):289-294