Article Sidebar

Submitted
12 January 2021
Accepted
12 January 2021
Published
31 March 2020
Download
PDF
Statistic
Read Counter : 640 Download : 508

Main Article Content

Abstract

Tumor and its microenvironment can interact each other. Macrophage is part of tumor microenvironment. New drugs targeting specific superficial receptor of macrophage or cytokine of macrophage polarization have been found. Therefore, macrophage phenotype and its ratio of M1/M2 macrophage need to be identified. This identification could lead us to prognose breast cancer and monitor its therapy. Analytical observational study with cross sectional approach, conducted on paraffin block sample of breast carcinoma from Anatomical Pathology Laboratory of Dr. Soetomo General Hospital. The samples divided into four groups based on nodal metastasis staging (N0, N1, N2, and N3) and stained with antibody against CD68 and CD163. The ratio of  CD68 and CD163 were analyzed with Anova test. There were difference expression of CD68 as M1 macrophage marker in various axillary node metastasis groups (p=0.015). There were difference ratio of CD68 as M1 macrophage marker and CD163 as M2 macrophage marker in various axillary node metastasis groups (p=0.005). There were difference ratio of macrophage M1 and macrophage M2 between N0 and N3 group, N2 and N3 group also.

Keywords

Macrophage M1 Macrophage M2 breast carcinoma

Article Details

License

Copyright (c) 2020 Folia Medica Indonesiana

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Wiratama, P. A., & Sandhika, W. (2020). Ratio of CD68/CD163 in Breast Carcinoma with and without Axillary Lymph Node Metastatic. Folia Medica Indonesiana, 56(1), 19–23. https://doi.org/10.20473/fmi.v56i1.24560
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Cao W, Peters JH, Nieman D (2015). Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro. British Journal of Cancer 113, 738-46
  2. Cui YL, Li HK, Zhou HY, Zhang T, et al (2013). Correlations of tumor-associated macrophage subtypes with liver metastases of colorectal cancer. Asian Pacific Journal of Cancer Preventio 14, 1003-7
  3. Gordon S (2003) Alternative activation of macrophages. National Review Immunology 3, 23-35
  4. Lucas T, Waisman A, Ranjan R, et al (2010). Differential roles of macrophages in diverse phases of skin repair. The Journal of Immunology 184, 3964-3977
  5. Mosser DM (2003). The many faces of macrophage activation. J Leukoc Biol 73, 209-212
  6. Obeid E, Nanda R, Fu, YX, Olopade OI (2013). The role of tumor-associated macrophage in breast cancer progression. International Journal of Oncology 43, 5-12.
  7. Qian B-Z, Pollard JW (2010). Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51
  8. Roszer T (2015). Understanding mysterious M2 macrophage through activation marker and effector mechanism. Hindawi Publishing Corporation, Mediator of Inflammation 2015
  9. Sica A, Mantovani A (2012). Macrophage plasticity and polarization: in vivo veritas. The Journal of Clinical Investigation 122, 787-95
  10. Srikrishna G, Freeze H (2009). Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer. Neoplasia 11, 615-28
  11. Takeuchi H, Michio T, Ayako T, et al (2015). Predominance of M2-polarized macrophages in bladder cancer affects angiogenesis, tumor grade and invasiveness. Oncology 11, 3403-3408
  12. Tu Z, Xiao R, Xiong J, et al (2016). CCR9 in cancer: oncogenic role and therapeutic targeting. Journal of Hematology and Oncology 9, 10
  13. Yafei Z, Jun G, Guolan G (2016). Correlation between macrophage infiltration and prognosis of ovarian cancer-a preliminary study. Biomedical Research (0970-938X) 27, p305-312

Most read articles by the same author(s)