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Abstract
It is well-known that hospitals are health facility with the widely use of antibiotics. It is about 13-37% from the total hospitalized patients in developed countries use antibiotic, even in developing countries can reach 30-80%. There is identified correlation between antibiotic use and the development of bacterial resistance. Even though the resistance cannot be eliminated, but its development can be suppressed by the increasing of prudent use of antibiotics. The aim of this study was to determine the quality of antibiotic use on internal medicine and surgical patients in Aisiyah Hospital Bojonegoro. The study was a prospective cross sectional observational analytical study of among patients of internal and surgical who received antibiotic therapy in the period of August - September 2017. The total 50 samples were collected in this study which consists of 33 internal medicine and 17 surgical patients. From 50 samples, there were 16 types of antibiotics with the total use of 81 of antibiotic use. As the result, in internal medicine patients there were 22 (40%) of appropriate use of antibiotics, 4 (7.27%) of inappropriate use and 29 (52.73%) use of antibiotics without indication. In surgical patients, there were 12 (46.15%) of appropriate use of antibiotics, 2 (7.69%) of inappropriate use and 12 (46.15%) use of antibiotics without indication. This study showed that more than 50% of antibiotic use were inappropriate, and mainly antibiotic with no indication, among patients hospitalized in Aisyiyah Hospital Bojonegoro.
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References
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References
Cunha, C.B. 2017. Principles of Antimicrobial Stewardship. In : Antimicrobial Stewardship Principles and Practice. London : CAB International, pp-1-5.
Gyssen I.C. and Van Der Meer, 2001. Quality of Antimicrobial Drug Prescription in Hospital, Eur Soc of Clin Microb and Infect Dis. pp-12-15.
Gyssens I.C. 2005. Audits for Monitoring the Quality of Antimicrobial Prescriptions. In: Gould IM., van der Meer JWM., Antibiotic Policies: Theory and Practice. Kluwer Academic/Plenum Publishers New York. pp-197-219.
Gyssens I.C. 2011. Antibiotic policy. J Antimicrob Ag, Elsevier. (38S) : pp- 11-20.
Gyssens, I.C. 2017. The Importance of Education in Antimicrobial Stewardship. In LaPlante, K. L., Cunha, C. B., Morrill, H. J., Rice, L. B, Antimicrobial Stewardship Principle and Practice. London : CAB International, pp-24-32.
Hadi, U., Kolopaking, E.P., Gardjito, W., Gyssens, I.C, van den Broek, P. 2006. Antimicrobial Resistance and Antibiotic Use in Low-Income and Developing Countries. Folia Medica Indonesiana. Vol. 42 (3) ; pp-183-195
Hadi, U., Keuter, M., van Asten, H., van den Broek, P. 2008. Optimizing Antibiotic Usage in Adult Admitted Fever by a Multifaceted Intervention in an Indonesian Government. Blackwell Publishing Ltd. Vol. 13 (7) ; pp-888-899.
Hadi, U., et al. 2008. Audit of Antibiotic Prescribing in Two Govermental Teaching Hospitals in Indonesia. Clinical Microbiology and Infection, Vol. 14. pp-698-707.
Hadi, U., Kuntaman., Qibtiyah, M., Paraton, H. 2013. Problem of Antibiotic and Antimicrobial Resistance in Indonesia : are we really making progress?. IJ Tropical and Infectious Disease, vol. 4(4) : pp-5-8
Kasper, D.L., Fauci, A.S., Hauser, S.L., Longo, D.L., Jameson, J.L., Loscalzo, J. 2015. Approach to Therapy for Bacterial Diseases. In Harrison's Principles of Internal Medicion 19th edition, New York : McGraw-Hill Companies, Inc. p-930.
Kemenkes RI, 2011. Pedoman Pelayanan Kefarmasian untuk Terapi Antibiotik. Dirjen Binfar, Jakarta, pp-1-71.
Kuntaman, 2010. Infection Control in Hospital: Focus on ESBL Producing Bacteria, in Kuntaman, Seminar Nosocomial Infection. CMP Medica, p-4.
Levinson, M. E, 2004. Pharmacodinamics of Antimicrobial Drugs, Infect Dis Clin N Am, Elsevier, Edinburgh, pp- 451-465.
Permenkes RI, 2015. Program Pengendalian Resistensi Antimikroba di Rumah Sakit. Menteri Kesehatan Republik Indonesia, pp-10-13.
Phillips, I. 2001. Prudent use of Antibiotics : Are Our Expectations Justified. Clinical Infection Disease. (Suppl 3) : S130-132.
Plachouras, D. et al. 2014. Promoting Prudent Use of Antibiotic : The Experience From a Multifacted Regional Campaign in Greece. BMC Public Health, vol. 14 : pp-866
Pritadewi, A.A. 2013. Analisis Penggunaan Antibiotika pada Pasien Sepsis Neonatorum, Ruang NICU, RSUP Sanglah Denpasar.
Reksoprawiro, 2009. Pedoman Penggunaan Antibiotika di Bidang Bedah, SMF Ilmu Bedah FK Unair-RSUD Dr Soetomo, Surabaya, pp. 419-450
Rice, L.B. 2017. Mechanism of Resistance to Antibacterial Agents. In LaPlante, K. L., Cunha, C. B., Morrill, H. J., Rice, L. B, Antimicrobial Stewardship Principles and Practice. London : CAB International, pp-39-48.
Tenofer, F. C, 2006. Mechanism of Antimicrobial Resistance in Bacteria, Centers for Disease Control and Prevention, vol. 34, no. 5: pp. S3-S10.
Tortora, G.J., Funke, B.R., Case, C.L. 2016. Microbiology an Introduction 12th edition, New York: Pearson Education, Inc, pp-550-574.
Van der meer, J.W.M., Gyssens, I.C. 2001. Quality of antimicrobial drug prescription in hospital. Clin. Microbial infect :7(6): pp-12-15.
Wagner, J.L., Davis, S.L. 2017. Principles of Switching from Intravenous to Oral Administration. In : Antimicrobial Stewardship Principles and Practice. London : CAB International, pp-255-264.
WHO, 2012. The evolving threat of antimicrobial resistance: Options for Actions. WHO Patient Safety Programme, GPS Publishing, Geneva. pp- 1-119.
WHO, 2014. Antimicrobial Resistance. Global Report on Surveillance, WHO Publishing, Geneva, pp-1-256.