Article Sidebar
Main Article Content
Abstract
Highlight:
- Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely.
- MCV levels could mirror health indicator in adult T2DM patients.
Abstract:
HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312; p<0.001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.
Keywords
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
- Alamri B, Bahabri A, Aldereihim A, et al (2019). Hyperglycemia effect on red blood cells indices. Eur. Rev. Med. Pharmacol. Sci. 23, 2139–2150.
- Eyth E, Naik R (2021). Hemoglobin A1C. StatPearls Publishing, Treasure Island.
- Leow M (2016). Glycated hemoglobin (HbA1c): Clinical applications of a mathematical concept. Acta Inform. Medica 24, 233–238.
- Maes M, Planken M, Gastel A, et al (1998). Influence of academic examination stress on hematological measurements in subjectively healthy volunteers. Psychiatry Res. 80, 201–212.
- Maner B, Moosavi L (2021). Mean corpuscular volume. StatPearls Publishing, Treasure Island.
- Morse E, Kalache G, Germino W, et al (1981). Increased electronic mean corpuscular volume induced by marked hyperglycemia. Ann. Clin. Lab. Sci. 11, 184–187.
- Nagao T, Hirokawa M (2017). Diagnosis and treatment of macrocytic anemias in adults. J. Gen. Fam. Med. 18, 200–204.
- World Health Organization (2021). Diabetes [WWW Document]. URL https://www.who.int/news-room/fact-sheets/detail/diabetes. Accessed January 5, 2022.
- PERKENI (2019). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. PB PERKENI, Jakarta.
- Rashed E, Alkout T, Eltomy S, et al (2020). The effects of red blood cells parameters on HbA1c and random blood sugar levels in diabetics diagnosis. Int. J. Diabetes Clin. Res. 7, 1–7.
- Rio M, Tiwari M, Amodu L, et al (2016). Glycated hemoglobin, plasma glucose, and erythrocyte aging. J. Diabetes Sci. Technol. 10, 1303–1307.
- Rodriguez-Segade S, Garcia J, Garcia-Lopez J, et al (2016). Impact of mean cell hemoglobin on HbA1c–defined glycemia status. Clin. Chem. 62, 1570–1578.
- Simmons D, Hlaing T (2014). Interpretation of HbA1c: association with mean cell volume and haemoglobin concentration. Medicine (Baltimore). 31, 1387–1392.
- Wang Y, Yang P, Yan Z, et al (2021). The relationship between erythrocytes and diabetes mellitus. J. Diabetes Res. 2021, 1–9.
- Yokoyama A (2003). Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 24, 1773–1778.
References
Alamri B, Bahabri A, Aldereihim A, et al (2019). Hyperglycemia effect on red blood cells indices. Eur. Rev. Med. Pharmacol. Sci. 23, 2139–2150.
Eyth E, Naik R (2021). Hemoglobin A1C. StatPearls Publishing, Treasure Island.
Leow M (2016). Glycated hemoglobin (HbA1c): Clinical applications of a mathematical concept. Acta Inform. Medica 24, 233–238.
Maes M, Planken M, Gastel A, et al (1998). Influence of academic examination stress on hematological measurements in subjectively healthy volunteers. Psychiatry Res. 80, 201–212.
Maner B, Moosavi L (2021). Mean corpuscular volume. StatPearls Publishing, Treasure Island.
Morse E, Kalache G, Germino W, et al (1981). Increased electronic mean corpuscular volume induced by marked hyperglycemia. Ann. Clin. Lab. Sci. 11, 184–187.
Nagao T, Hirokawa M (2017). Diagnosis and treatment of macrocytic anemias in adults. J. Gen. Fam. Med. 18, 200–204.
World Health Organization (2021). Diabetes [WWW Document]. URL https://www.who.int/news-room/fact-sheets/detail/diabetes. Accessed January 5, 2022.
PERKENI (2019). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. PB PERKENI, Jakarta.
Rashed E, Alkout T, Eltomy S, et al (2020). The effects of red blood cells parameters on HbA1c and random blood sugar levels in diabetics diagnosis. Int. J. Diabetes Clin. Res. 7, 1–7.
Rio M, Tiwari M, Amodu L, et al (2016). Glycated hemoglobin, plasma glucose, and erythrocyte aging. J. Diabetes Sci. Technol. 10, 1303–1307.
Rodriguez-Segade S, Garcia J, Garcia-Lopez J, et al (2016). Impact of mean cell hemoglobin on HbA1c–defined glycemia status. Clin. Chem. 62, 1570–1578.
Simmons D, Hlaing T (2014). Interpretation of HbA1c: association with mean cell volume and haemoglobin concentration. Medicine (Baltimore). 31, 1387–1392.
Wang Y, Yang P, Yan Z, et al (2021). The relationship between erythrocytes and diabetes mellitus. J. Diabetes Res. 2021, 1–9.
Yokoyama A (2003). Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 24, 1773–1778.