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Abstract

The aim of this study was to determine the comparative effects of EA (EA) on the CV12, ST36 and ST40 to weight gain prevention over the short-term regulation of energy balance. The study was conducted with a completely randomized design. Rats were divided into five groups: negative control group (no treatment, n=5), positive control (sham EA/back, n=5), EA CV 12 (n=6), EA ST 36 (n=6) and EA ST 40 (n=7). Rats were exposed to high-fat diet for two weeks and EA was simultaneously performed once daily, five days a week for two weeks with 2 Hz, for 10 minutes with continuous wave. Body weight, BMI, front limb circumference and rear were measured during study. Levels of blood glucose, cholesterol, triglycerides, LDL and HDL were measured at the end of the study; which reflects the short-term regulation of energy homeostasis. For weight loss, EA CV12, ST36 and ST40 group have lost weight significantly compared to the negative and positive control group. The ST40 group has a significant decrease than ST36 and CV12. The most significant decrease in BMI found in the ST40 group. EA did not affect blood glucose levels, but modulated blood lipid profile. In ST 40 group there was a significant decrease in cholesterol, LDL and triglycerides. EA at point ST 40 is potential in preventing increased body weight and BMI in rats exposed to high-fat diet compared to the CV 12 and ST 36. ST 40 is a point with a potential of lowering LDL and triglycerides serum so that it can play a role in the short term regulation of energy homeostasis but also in the prevention of dyslipidemia.

Keywords

electroacupuncture energy homeostasis glucose levels lipid profile BMI

Article Details

How to Cite
Rejeki, P. S., Harjanto, H., Argarini, R., & Subadi, I. (2017). COMPARISON EFFECT OF CV 12, ST 36 AND ST 40 EA ON SHORT TERM ENERGY BALANCE REGULATION IN HIGH FAT DIET RAT. Folia Medica Indonesiana, 52(3), 174–179. https://doi.org/10.20473/fmi.v52i3.5448

References

  1. Ainslie DA, Proietto J, Fam BC, Thorburn AW (2000). Short-term, high-fat diets lower circulating leptin concentrations in rats. Am J Clin Nutr 71, 438-442
  2. Havel PJ (2001). Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med 226, 963–977
  3. Irani BG, Dunn-Meynell AA, Levin BE (2007). Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology 148, 310–316
  4. Lacey JM, Tershakovec AM, Foster JD (2003). Acupuncture for the treatment of obesity: a review of the evidence. International Journal of Obesity 27, 419–427
  5. Ma SX (2004). Neurobiology of acupuncture: toward CAM. Evidence-Based Complementary and Alternative Medicine 1, 41–47
  6. Mori MA, Arau´RJ, Reis FCG, Sgai DG, Fonseca RG, Barros CC, Merino VF, Passadore M, Barbosa AM, Ferrari B, Carayon P, Castro CHM, Shimuta SI, Luz J, Bascands JL, Schanstra JP, Even PC, Oliveira SM, Bader M, PesqueroJB (2008). Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity. Diabetes 57, 1491–1500
  7. Ouyang H, Yin J, Wang Z, Pasricha PJ, Chen JD (2002). EA accelerates gastric emptying in association with changes in vagal activity. Am J Physiol Gastrointest Liver Physiol 282, G390-396
  8. Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA (2003). Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6–dependent insulin resistance in hepatocytes. J Biol Chem 278, 13740 –13746
  9. Stux G and Pomeranz B (1997). Basics of acupuncture, 4th ed, Berlin, Springer-Verlag
  10. Tulipano G, Vergoni AV, Soldi1 D, Muller EE, Cocchi1 D (2004). Characterization of the resistance to the anorectic and endocrine effects of leptin in obesity-prone and obesity-resistant rats fed a high-fat diet. Journal of Endocrinology 183, 289–298
  11. Yepuru M, Eswaraka J, Kearbey JD, Barrett CMM, Raghow S, Veverka KA, Miller DD, Dalton JT, Narayanan R (2010). Estrogen receptor-b-selective ligands alleviate high-fat diet- and ovariectomy-induced obesity in mice. J Biol Chem 285, 31292-31303
  12. Zhang HX, Wu H, Huang H, Xiao Y, Wang D (2013). Effects of electroacupuncture stimulation of "Fenglong" (ST 40) on expression of liver ATP-binding cassette transporter A 1 mRNA and protein in rats with hyperlipidemia. Acupuncture Research 38, 100-105

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