Main Article Content


Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.


advanced cervical cancer serotonin depression score quality of life CBT

Article Details

How to Cite
Soetrisno, S., Sulistyowati, S., Respati, S. H., & Nasrudin, M. (2017). EFFECT OF COGNITIVE BEHAVIORAL THERAPY FOR SEROTONIN LEVEL, DEPRESSION SCORE AND QUALITY OF LIFE IN CERVICAL CANCER PATIENTS. Folia Medica Indonesiana, 52(3), 231–234.


  1. Himpunan Onkologi Ginekologi Indonesia (2013). Panduan Pelayanan Klinik Kanker Ginekologi, Jakarta Himpunan Onkologi Ginekologi Indonesia
  2. IARC (2005). Cervical cancer screening: IARC handobook of cancer prevention Volume 10. Available from pdfs-online/prev/handbook10/. Accessed May 15, 2015
  3. Irianto B (2015). Pengaruh Cognitive Behavioural Therapy (CBT) terhadap kadar kortisol dan skor beck depression inventory pada pasien kanker serviks stadium lanjut. Thesis. Universitas Sebelas Maret, Surakarta
  4. Krebs (2003). Management of Concomitant Depression and Physical Illness. Available from Accessed May 15, 2015
  5. Limberaki E, Eleftheriou P, Gasparis G, Karalekos E, Kostoglou V, Petrou C (2011). Cortisol levels and serum antioxidant status following chemotherapy. Health 3, 512-517
  6. Pramudhita R (2015). Perbedaan kadar kortisol serum pasien kanker serviks stadium lanjut setelah intervensi cognitive behavior therapi (Cbt) dengan terapi standar, Thesis. Universitas Sebelas Maret, Surakarta
  7. Prawiroharjo S (2010). Buku Acuan Nasional Onkologi dan Ginekologi, Jakarta, Balai Penerbit Bina Pustaka, p 442-454
  8. Ruiz de Gordoa JC, Santafé J, Segarra Domenech J, Santisteban A (1994). Modification of rat plasma lipoproteins induced by acute immobilization stress. Psychosom Med 56, 486-492
  9. Salim OC, Sudharma NI, Kusumaratna RK, Hidayat A (2007). Validitas dan reliabilitas World Health Organization Quality of Life-BREF untuk mengukur kualitas hidup lanjut usia. Universa Medicina 26, 27-38
  10. Schiff D (2003). Cancer Neurology in Clinical Practice, New Jersey, Humana Press Inc
  11. Soetrisno (2009). Ekspresi heat shock protein 60,70,90 dan kortisol pada persalinan ibu primigravida yang mendapat psikokuratif. Dissertation. Universitas Airlangga, Surabaya
  12. Surveillance Epidemiology and End Result Program (SEER) (2012). Cervix Uteri Cancer. National Cancer Institute