Article Sidebar

Submitted
14 August 2017
Accepted
14 August 2017
Published
14 August 2017
Download
PDF
Statistic
Read Counter : 852 Download : 1005

Main Article Content

Abstract

Migraine is a health problem which had big impact. A neurochemistry change in the dura, that is the increase of the amount of nitrite oxide, originated from an excessive NOS (inducible NOS) activation during ictal. Some researchers assume NO as a main cause of the pain intensity in ictal. Migraine diagnosis is guided by the International Headache Society. Hopefully, this examination can be used as a more objective diagnosis in the future. Methode of this research is descriptive analytic. This study to find the level of endogenous exhaled NO on 91 subject, consisting of  30 normal people, 31 interictal, 30 ictal. An exclusion was done previously. A validation equipment and measurement had been done in accordance with American Thoracic Association guidance. The result is level of endogenous exhaled NO on the normal group (median=5), interictal group (median=11), ictal group (median=14). Coefficient correlation between VAS and level endogenous exhaled NO was 0,815. So, there is an increase of the NO endogen level in the normal people, migraine interictal, and ictal. Strong correlation between intensity of pain (VAS) and level endogenous exhaled NO during ictal.

Keywords

migraine endogenous exhaled NO

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Saleh, A. Y., Machfoed, H., & Kuntoro, K. (2017). THE PROFILE OF THE LEVEL OF ENDOGENOUS NO IN MIGRAINE SUFFERERS. Folia Medica Indonesiana, 52(4), 290–295. https://doi.org/10.20473/fmi.v52i4.5478
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Ahern G, Hsu S, Klyachko V, Jackson M (2000). Induction of persistent sodium current by exogenous and endogenous nitric oxide. Journal of Biology Chemistry 275, 28810-28815
  2. Alving K, Janson C, Nordvall L (2006). Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Journal of Respiratory Research 7, 67
  3. American Thoracic Society; European Respiratory Society (2005). ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. American Journal of Respiratory of Critical Care Medicine 171, 912-930
  4. Cohen RA (1999). The potential clinical impact of 20 years of nitric oxide research. American Journal of Physiology of Heart and Circulatoty Physiology 276, 1404-1407
  5. Consort (2010). Consort: transparent reporting of trials. Available from http://www.consort-statement.org/ consort-statement/13-19---results/item15_baseline-data/. Accessed December 13, 2015
  6. Dahlan MS (2010). Membaca dan Menelaah Jurnal Uji Klinis, Jakarta, Salemba Medika
  7. Dowson AJ (2003). Migraine and other Headaches, Your Question Answered, London, Churchill Livingstone
  8. Garthwaite J (2008). Concepts of neural nitric oxide-mediated transmission. European Journal of Neuroscience 27, 2783-2802
  9. Goadsby PJ, Lipton RB, Ferrari MD (2002). Migraine current understanding and treatment. The New England Journal of Medicine 346, 257-270
  10. Greco R, Gasperi V, Maccarrone M, Tassorelli C (2010). The endocannabinoid system and migraine. Experimental Neurology 224, 85-91
  11. Grob N, Laskowski D, Dweik R (2008). A technical report on exhaled nitric oxide measurement: asthma monitoring in athletes. J Breath Res 2, 37027
  12. Gupta S, Mehrotra S, Villalón CM, Perusquí­a M., Pramod RS, Maassen VA (2007). Potential role of female sex hormones in the pathophysiology of migraine. Pharmacology & Therapeutics 113, 89
  13. Hemmingsson T, Linnarsson D, Gambert R (2004). Novel hand-held device exhaled nitric oxide-analysis in research and clinical application. Journal of Clinical Monitoring and Computer 18, 379-387
  14. Kurihara N, Alfie ME, Sigmon DH, Rhaleb NE, Shesely EG, Carretero OA (1998). Role of nNOS in blood pressure regulation in eNOS null mutant mice. Hypertension 32, 856-861
  15. Marcelo E, Bigal MD, Richard B, Lipton MD (2006). Modifiable risk factors for migraine progression. Headache 46, 1334-1343
  16. Motulsky H (2010). Intuitive Biostatistics, Britania Raya, Oxford University Press
  17. Olesen J and Lance JW (2004). Chepalalgia. The Inter-national Classification of Headache Disorders 24, 20-25
  18. Perdossi (2006). Epidemiologi of Headache in Indonesia, Bogor, PERDOSSI
  19. Pett AM (1997). Nonparametric Statistics For Health Care Research, Statistic for Small Samples and Unusual Distributions, London, SAGE Publication
  20. Riyanto B (1995). Masalah diagnosis nyeri kepala. Cermin Dunia Kedokteran 104, 10-15
  21. Sanders DH (1980). Statistics: A Fresh Approach, 2nd edition, Philadelphia, McGraw-Hill
  22. Schueren, BJ, Lunnon MW, Laurijssens BE, Guilard F, Palmer J, Hecken AV, Hoon JND (2009). Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficiency in acute migraine?. Journal of Clinical Pharmacology 49, 281-290
  23. Sokolovic E (2005). Prevalence of tension-type headache and migraine among the employees of the Swiss University hospital, their impact on disability, headache management and economic impact for the employer. Master Thesis. pp: 1-5
  24. Vints AM, Oostveen E, Eeckhaut G, Smolders M, De Backer WA (2005). Time-dependent effect of nitrate-rich meals on exhaled nitric oxide in healthy subjects. Chest 128, 2465-2470