Article Sidebar

Submitted
15 August 2017
Accepted
15 August 2017
Published
15 August 2017
Download
PDF
Statistic
Read Counter : 926 Download : 1099

Main Article Content

Abstract

This study aims to determine the potency of CV 12 acupuncture as prevention of weight gain in ovariectomizedmice (OVX). Female mice strain BALB/c, 28 mice, 3-4 weeks, 25-35 grams were divided into four groups; namely K1 (n = 8, sham and vehiculum injection), K2 (n = 8, OVX and vehiculum injection), K3 (n = 7, OVX and injection of estrogen intraperitoneal 10 mg/kg/day) and K4 (n = 6, OVX and CV12 acupuncture with a frequency of 2 Hz in 10 mA of continuous spike current wave).Injection and acupuncture given every day for four weeks. Weight change in K1 (0.75 ± 2.8) grams, K2 (2.71 ± 2.4) grams, K3 (0.71 ± 0.95) g and K4 (0.93 ± 2.40) gram with a significant difference in the K2 and K4 (p = 0.011). a receptor expression in K1 (12.25 ± 2.96), K2 (5.43 ± 2.64), K3 (18.86 ± 1.57), K4 (17 ± 2.00) with a significant difference to the K2 K1, K3 and K4 with p<0.05. b receptor expression in K1 (11.38 ± 1.92), K2 (4 ± 1.41), K3 (16.86 ± 1.86), K4 (14.17 ± 5.24) with significantly different a receptor expression in visceral fat mass on the group K2 to K1, K3 and K4 with p<0.05. CV 12 acupuncture increases the expression of a and b estrogen receptor in visceral adipose tissue of OVX mice equivalently and able to prevent the increase of weight due to the estrogen withdrawal. This point could potentially be used as one of the management ofobesity prevention in menopause.

Keywords

mice ovariectomy acupuncture CV 12 ER ER

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Rejeki, P. S., Wiyasihati, S. I., & Atika, A. (2017). POTENCY OF CV12 ACUPUNCTURE AS OBESITY PREVENTION THROUGH MODULATION OF  AND  ESTROGEN RECEPTORS EXPRESSION ON THE ADIPOSE TISSUE OF OVARIECTOMIZED MICE. Folia Medica Indonesiana, 53(1), 24–28. https://doi.org/10.20473/fmi.v53i1.5496
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Allende-Vigo, MZ, 2008. P.R Health Sci J. 27, 190-195
  2. Ariazi EA and Jordan VC, 2006.Curr Top Med Chem, 6, 203-215
  3. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM and Kahn CR, 2009. N Engl J Med, 360, 1509-17
  4. Flegal KM, Graubard BI, Williamson DF, Gail MH. 2005. Excess deaths associated with underweight, overweight, and obesity. JAMA 293:1861–1867
  5. Foryst-Ludwig A, Clemenz M, Hohmann S, Hartge M, Sprang C, Frost N, Krikov M, et al., 2008. PloS Genet 4, e1000108
  6. Friedman JM. 2004. Modern science versus the stigma of obesity.Nat Med 10:563–569.
  7. Geer, EB and Shen W, 2009. Gen Med, Suppl,l, 60-75
  8. Hadi H, 2005, Beban Ganda Masalah Gizi dan Impli-kasinya terhadap Kebijakan Pembangunan Kesehatan Nasional, Pidato pengukuhan Guru Besar, FKUGM, available at http://www.gizi.net/cgibin/berita/fullnews. cgi/newsid1109302893, 75841
  9. Hill JO, Wyatt HR, Reed GW, Peters JC. 2003. Obesity and the environment: where do we go from here? Science 299:853– 855.
  10. Kopelman PG. 2000. Obesity as a medical problem. Nature 404:635– 643
  11. Lacey JM, TershakovecAM and Foster JD, 2003. Acupuncture for the treatment of obesity: a review of the evidence, International Journal of Obesity 27, 419–427
  12. Miller CN, Brown LM, Rayalam S, Della-Fera M, Baile CA, 2011. Estrogens, inflammation and obesity: an overview, Front. Biol., DOI 10.1007/s11515-011-1174-y
  13. Modder et al,. 2004. Dose-responseof estrogen on bone versus the uterus in ovariectomized mice, European Journal of Endocrinology, 157.503-10
  14. Ma SX, 2004. Neurobiology of Acupuncture: Toward CAM, CAM;1(1)41–47
  15. Mori MA, Arau´RJ, Reis FCG, Sgai DG, Fonseca RG, Barros CC, Merino VF, Passadore M, Barbosa AM, Ferrari B, Carayon P, Castro CHM, Shimuta SI, Luz J, Bascands JL, Schanstra JP, Even PC, Oliveira SM, Bader M, and PesqueroJB. 2008. Kinin B1 Receptor Deficiency Leads to Leptin Hypersensitivity and Resistance to Obesity. Diabetes 57:1491–1500
  16. Ouyang H, Yin J, Wang Z, Pasricha PJ, and Chen JD., 2002. Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J PhysiolGastrointest Liver Physiol282: G390-396.
  17. Weinstock RS, Dai H and Wadden TA, 1998. Diet and exercise in the treatment of obesity. Archives of Internal Medicine, 158(22), 2477–2483.
  18. Somoza B, Guzma R, Cano V, Merino B, Ramos P, Di´ez-Fernandez C, Fernandez-Alfonso MS, and Mariano RG. 2007. Induction of Cardiac Uncoupling Protein-2 Expression and Adenosine 5_-Monophosphate-Activated Protein Kinase Phosphorylation during Early States of Diet-Induced Obesity in Mice.Endocrinology148: 924–931
  19. Vickers A, Zollman C. ABC of complementary medicine: acupuncture. BMJ 1999; 319: 973–976.
  20. Yepuru M, Eswaraka J, Kearbey JD, Barrett CM, Raghow S, Veverka KA, Miller DD, Dalton JT and Narayanan R, 2010. Molecular Bases of Disease: Estrogen Receptor ? selective Ligands Alleviate High Fat Diet and Ovariectomy-induced Obesity in Mice, J,Biol. Chem, 285:31292-303.

Most read articles by the same author(s)

1 2 > >>