Article Sidebar

Submitted
5 July 2018
Accepted
5 July 2018
Published
5 July 2018
Download
PDF
Statistic
Read Counter : 1013 Download : 1052

Main Article Content

Abstract

There is an increase in renal cell carcinoma in males aged over fifty years with smoking risk factors. Clear cell renal cell carcinoma is the most common malignant tumor found in the kidneys that have an aggressive nature. This carcinoma is classified according to TNM into T1, T2, T3 and T4 stages. The higher the T stage, the worse the prognosis of the patient, as it involves the role of the HIF-1a transcription factor accumulated under hypoxic condition due to inactivation of VHL, thus activating VEGF. So far, clear cell renal cell carcinoma frequently found in smoking males of fifth decade of age or older has not been explained.. An observational analytic study was conducted on the sample of paraffin blocks of patients with clear cell renal cell carcinoma in 2010-2016. T1, T2, T3, and T4 stages of 9 samples, 12 samples, 12 samples and 6 samples, respectively, were collected in Anatomic Pathology Laboratory, Dr. Soetomo Hospital, Surabaya. Detection of HIF-1a and VEGF expression was performed using immunohisto-chemical immunity with HIF-1a and VEGF antibodies. The results were analyzed statistically by Kruskal-Wallis and Mann-Whitney methods. The correlation between HIF-1a and VEGF in T stages was analyzed using Spearman method. There was a difference of HIF-1a expression between stage T1 with T2, T1 with T3, T1 with T4 (p=0.041, p=0.000, and p=0.002), stage T2 with T3 and stage T2 with T4 (p=0.001, and p=0.013). There was a difference in VEGF expression in stage T1 with T2, T1 with T3, T1 with T4 (p=0.007, p=0.000, and p=0.002), and stage T2 with T3 (p=0,001). There was a correlation between HIF-1a and VEGF expressions with all T stages (rs=0.624 with p 0.000). As a conclusion, the higher the stage of T, the higher the expression of HIF-1a and VEGF. The higher the levels of HIF-1a and VEGF, the worse the prognosis of clear cell renal carcinoma. HIF-1a and VEGF play a role in the pathogenesis of clear cell renal cell carcinoma. Thus, HIF-1a and VEGF can be developed as prognostic markers.

Increased Hif-1aAnd Vegf Expression Found In Various T Stages Of Clear Cell Renal Cell Carcinoma

Keywords

Clear cell renal cell carcinoma HIF-1alpha VEGF T stages

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Octavianda, Y., & Rahaju, A. S. (2018). Increased HIF-1alpha And VEGF Expression Found in Various T Stages of Clear Cell Renal Cell Carcinoma. Folia Medica Indonesiana, 54(2), 102–107. https://doi.org/10.20473/fmi.v54i2.8858
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. De S, Dey YN, Sarkar P, Gaidhani S (2012). An over-view of angiogenesis and renal cell carcinoma. Inter-national Journal of Nutrition, Pharmacology, and Neurological Diseases 2, 3-7
  2. Hudes G, Rini B, Srinivas S (2008). Antiangiogenic therapy for advanced renal cell carcinoma.” Angio-genesis Foundation,1-2
  3. Knock B, Skuli N, Simon C (2011). Hypoxia-induced angiogenesis: good and evil. Genes and Cancer 2, 1117-1133
  4. Lidgren A, Hedberg Y, Grankvist K, Rasmuson T, Bergh A, Ljungberg B (2006). Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analy-zed by tissue microarray. Eur Urol 50, 1272-1277
  5. Murphy WM, Grignon DJ, Perlman EJ (2011). AFIP atlas of tumor pathology. Tumors of the kidney, bladder, and related urinary structure. Washington DC, Springer-Verlag, p 101-159
  6. Pantuck, et al (2003). Pathobiology, prognosis and targeted theraphy for renal cell carcinoma: Exploiting the hypoxia-induced pathway. Clinical cancer Research 9, 4641-4652
  7. Papetti M, Herman IM (2002). Mechanism of normal and tumor-derived angiogenesis. Am J Physiol Cell Physiol 282, C947-C970
  8. Umbas R, et al (2012). Panduan penanganan kanker ginjal. Ikatan Ahli Urologi Indonesia, 1-20
  9. Vaupel P (2004). The role of hypoxia-induced factors in tumor progression. The Oncologist 9, 10-17
  10. Wan L, et al (2015). Expression and significance of FOXP1, HIF-1ï¡ and VEGF in renal clear cell carcinoma. JBUON 2015 20, 188-195
  11. Waxman J (2005). Renal cell carcinoma. Journal of Urological Cancers, 274
  12. Weldemann A, Johnson RS (2008). Biology of HIF-1ï¡. Nature Publishing Group, 621-627