Article Sidebar

Submitted
5 July 2018
Accepted
5 July 2018
Published
5 July 2018
Download
PDF
Statistic
Read Counter : 744 Download : 812

Main Article Content

Abstract

Diabetes mellitus is a type of a degenerative disorder that affects the body's ability to make or use insulin. The resistance of insulin may affect the decline of GLUT-1 expression of diabetic muscle, causing impaired glucose uptake. Dynamic concentric activity is one of the activity models based on muscle-contraction-type activity. This study used experimental method. The instrument in this study was a treadmill (brand: modified columbus treadmill) with 10-degree slope (uphill), with the velocity of 21 cm/sec (the speed options showed on the treadmill), and the duration of the exercise was 16 minutes and 30 seconds (measured using stopwatch). In this study, there were 3 groups of samples, Normal (K0), DM (K1), and DM + Dynamics Concentric (K2). Based on statistical results of correlation value p=0.00 (p<0.05), there was significant correlation between blood sugar level and GLUT-1. Dynamic concentric activity for diabetics had an effect in increasing the amount of GLUT-1, resulting in decreased blood glucose levels.

Keywords

Diabetic concentric dynamic GLUT-1

Article Details

License

  • Folia Medica Indonesiana is a scientific peer-reviewed article which freely available to be accessed, downloaded, and used for research purposes. Folia Medica Indonesiana (p-ISSN: 2541-1012; e-ISSN: 2528-2018) is licensed under a Creative Commons Attribution 4.0 International License. Manuscripts submitted to Folia Medica Indonesiana are published under the terms of the Creative Commons License. The terms of the license are:

    Attribution ” You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

    NonCommercial ” You may not use the material for commercial purposes.

    ShareAlike ” If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.

    No additional restrictions ” You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

    You  are free to :

    Share ” copy and redistribute the material in any medium or format.

    Adapt ” remix, transform, and build upon the material.

How to Cite
Yusuf, H., & Safitri, D. (2018). Dynamic Concentric Activity Can Increase the GLUT-1 Expression on Muscle Membrane on Diabetic Mice. Folia Medica Indonesiana, 54(2), 113–115. https://doi.org/10.20473/fmi.v54i2.8860
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Alessio HM, Hagerman AE (2006). Oxidative stress, exercise and aging. London, Imperial College Press
  2. Chambers MA, Moylan JS, Smith JD, Goodyear LJ, Reid MB (2009). Stretch stimulated glucose uptake in skeletal muscle is mediated by ROS & p38 MAPK. The Journal of Physiology 587, 3363-3373
  3. Ciaraldi TP, Mudaliar S, Barzin A, Macievic JA, Edelman SV, Park KS, Henry RR (2005). Skeletal muscle GLUT-1 transporter proteine expression & basal leg glucose uptake are reduced in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 90, 352-358
  4. Kelompok Kajian Animal Modelling Research (KKAMR) (2013). Model hewan coba untuk penelitian diabetes - Seri 1
  5. Riaz S (2009). Diabetes mellitus. Scientific Research and Essay 4, 367-373. Available from http://www. academicjournals.org/SRE. Accessed Agustus 4, 2017
  6. Xi X, Han J, Zhang JZ (2001). Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase. Journal of Biological Chemistry 276, 41029-41034
  7. Zhan ME, Jin SE, Reecy JM, Li1 YP (2006). TACE release of TNFa mediates mechanotransduction-induced activation of p38 MAPK and myogenesis. Journal of Cell Science 120, 692-701
  8. Zainuddin M (2000). Metodologi Penelitian dan Statis-tika. Surabaya, Universitas Airlangga