Relationship Between the Age of Female Partner and the Intrauterine Insemination Success in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar
Downloads
Infertility is the inability of couples who have regular sexual intercourse without using protection to achieve pregnancy within one year. The prevalence of infertility was 21.3% in Indonesia. Intrauterine Insemination (IUI) is an assisted reproductive technology chosen by infertile couples to have children. Various factors influence the success of IUI. One factor that influences the success of IUI is the female partner's age. To determine the relationship between the age of female partners and the success of IUI. This study is descriptive-analytical research with the Cross-Sectional method using secondary data obtained from medical records of patients who underwent IUI procedures from January to March 2020 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. Total research subjects are 31 patients with an average age of 32 years. Positive pregnancies in female partners aged 25-35 years are 8 patients (33,3%) and female partners aged 35-40 are 1 patient (14.3%). Most patients had secondary infertility with a duration of 1-3 years. There is no relation between the increasing age of female partners and the decreasing success of IUI at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar (p=0,329). But female partners aged 25-35 years tended to have a positive pregnancy 2,333 times higher than female partners aged 35-40 years (RR=2,333; CI 95%: 0,349-15,612).
WHO. Infertility Definitions and Terminology. Human Reproduction Programme. World Health Organization; 2021. p. 1.
Soebijanto S. Konsensus Penanganan Infertilitas. Konsensus penanganan infertil. 2013.
Guan H, Tang H, Pan L, Song H, Tang L. Pregnancy Predictors in Unexplained Infertility After Intrauterine Insemination. Vol. 50, Journal of Gynecology Obstetrics and Human Reproduction. Elsevier Masson; 2021. p. 102071.
Patel AP, Patel MS, Shah SR, Jani SK. Predictive Factors For Pregnancy After Intrauterine Insemination: A Retrospective Study of Factors Affecting Outcome. J SAFOG. 2016;8(2):140–144.
Govindarajan M, Mallikarjunan S, Ahmed HR, Lakshmanan N, Silambuchelvi D, Sujatha M, et al. Retrospective Study of Factors Affecting Intrauterine Insemination Pregnancy Outcome: The Impact of Male Habits and Working Environment. J Hum Reprod Sci. 2017;10(2):114.
Dua M, Malik S, Prakash V, Bhatia V. ART Outcome in Young Women With Premature Ovarian Aging. J Midlife Health. 2013;4(4):230.
Revelli, A. et al. IVF Results in Patients with Very Low Serum AMH are Significantly Affected by Chronological Age, Journal of Assisted Reproduction and Genetics. Springer, 2016. 33(5):603–609.
K. J, Abraham S, Nambiar D. Factors Affecting Success of Intrauterine Insemination: A 3 Year Prospective Study. Int J Reprod Contraception, Obstet Gynecol. 2016;5(4):1077–1083.
Atasever M, Kalem MN, Hatırnaz Åž, Hatırnaz E, Kalem Z, Kalaylıoğlu Z. Factors Affecting Clinical Pregnancy Rates After IUI for The Treatment of Unexplained Infertility and Mild Male Subfertility. J Turkish Ger Gynecol Assoc. 2016;17(3):134–138.
Vichinsartvichai P, Siriphadung S, Traipak K, Promrungrueng P, Manolertthewan C, Ratchanon S. The Influence of Women Age and Successfulness of Intrauterine Insemination (IUI) Cycles. J Med Assoc Thai. 2015;98(9):833–838.
Ashrafi M, Rashidi M, Ghasemi A, Arabipoor A, Daghighi S, Pourasghari P, et al. The Role of Infertility Etiology in Success Rate of Intrauterine Insemination Cycles: An Evaluation of Predictive Factors for Pregnancy Rate. Int J Fertil Steril. 2013;7(2):100–107.
Hoshino, Y. Updating The Markers for Oocyte Quality Evaluation: Intracellular Temperature as A New Index, Reproductive Medicine and Biology. Wiley-Blackwell, 2018. pp. 434–441.
Crawford NM, Steiner AZ. Age-related infertility. Vol. 42, Obstetrics and Gynecology Clinics of North America. Obstet Gynecol Clin North Am; 2015. p. 15–25.
Kini S, Li HWR, Morrell D, Pickering S, Thong KJ. Anti-Mullerian Hormone and Cumulative Pregnancy Outcome In In-Vitro Fertilization. J Assist Reprod Genet. 2010;27(8):449–456.
Wang S, Zhang Y, Mensah V, Huber WJ, Huang YT, Alvero R. Discordant Anti-Müllerian Hormone (AMH) and Follicle Stimulating Hormone (FSH) among Women Undergoing In Vitro Fertilization (IVF): Which One ss The Better Predictor For Live Birth?, Journal of Ovarian Research. J Ovarian Res, 2018. 11(1).
Jeon YE, Jung JA, Kim HY, Seo SK, Cho SH, Choi YS, et al. Predictive Factors for Pregnancy During The First Four Intrauterine Insemination Cycles Using Gonadotropin. Gynecol Endocrinol. 2013;29(9):834–838.
Weiss NS, Van Vliet MN, Limpens J, Hompes PGA, Lambalk CB, Mochtar MH, et al. Endometrial Thickness in Women Undergoing Iui With Ovarian Stimulation. How Thick is Too Thin? A Systematic Review and Meta-Analysis. Vol. 32, Human Reproduction. Oxford Academic; 2017. p. 1009–1018.
Liu Y, Ye XY, Chan C. The Association Between Endometrial Thickness and Pregnancy Outcome in Gonadotropin-Stimulated Intrauterine Insemination Cycles. Reprod Biol Endocrinol. 2019;17(1):1–8.
Yavuz A, Demirci O, Sözen H, Uludoğan M. Predictive Factors Influencing Pregnancy Rates After Intrauterine Insemination. Iran J Reprod Med. 2013;11(3):227–234.
Panda B, Mohapatra L, Sahu MC, Padhy RN. Success in Pregnancy Through Intrauterine Insemination at First Cycle In 300 Infertile Couples: An Analysis. J Obstet Gynecol India. 2014;64(2):134–142.
Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, et al. Letrozole, Gonadotropin, or Clomiphene for Unexplained Infertility. N Engl J Med. 2015;373(13):1230–1240.
Rachmiawaty A, Djuwantono T, Sasotya RMS. Analisis Faktor yang Mempengaruhi Keberhasilan Kehamilan pada Inseminasi Intrauterin. Indones J Obstet Gynecol Sci. 2018;1(1):24–30.
Dorjpurev U, Kuwahara A, Yano Y, Taniguchi T, Yamamoto Y, Suto A, et al. Effect of Semen Characteristics on Pregnancy Rate Following Intrauterine Insemination. J Med Investig. 2011;58(1–2):127–133.
Allow AK, Abdulmogny SSM, Maryam B, Ghafouri KN, Fakhrildin M-B, Muhamad, et al. The Relationship between Duration of Infertility and Intrauterine Insemination: A Multi-Centers Study. J Clin Dev Biol. 2016;1(3):1–7.
Schorsch M, Gomez R, Hahn T, Hoelscher-Obermaier J, Seufert R, Skala C. Success Rate of Inseminations Dependent on Maternal Age? An Analysis of 4246 Insemination Cycles. Geburtshilfe Frauenheilkd. 2013;73(8):808–811.
Copyright (c) 2022 Indonesian Andrology and Biomedical Journal
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
