Post-Preparation Total Motile Sperm Count in Infertile Men and The Success Rate of Intrauterine Insemination at Rumah Sakit Kasih Ibu Denpasar in 2022
Downloads
Background: Every married couple hopes to have children, but not all can fulfil that desire. A married couple finds themselves unable to achieve pregnancy after 12 months of regular unprotected sexual intercourse, which can be called infertility. Infertility can also occur in men. In dealing with infertility, intrauterine insemination (IUI) is a cost-effective and non-invasive Assisted Reproductive Technology (ART) procedure. The condition of male infertility can be detected through semen analysis. One of the parameters in semen analysis is the total motile sperm count (TMSC).
Objective: This research seeks to establish the relationship between post-preparation TMSC and the success rate of the IUI procedure.
Methods: This research adopts a descriptive-analytical design employing a cross-sectional methodology. Non-probability sampling was utilized as the sampling technique, and the data analyzed were secondary data from the medical records of male patients aged 25 to 45 years old diagnosed with infertility. The subjects had undergone IUI at Rumah Sakit Kasih Ibu Denpasar from January 1 to December 31, 2022.
Results: From the 35 obtained samples, 12 individuals (34.3%) had a post-preparation TMSC of ≥10 í— 106, while 23 individuals (65.7%) had a post-preparation TMSC of <10 í— 106. The success rate of the Intrauterine Insemination (IUI) procedure was 17.1%, with 4 couples (33.3%) having a post-preparation TMSC of ≥10 í— 106 and 2 couples (8.7%) with a post-preparation TMSC of <10 í— 106. The Fisher's Exact test carried out has obtained a result (p=0.151), while the value of the odds ratio (OR) obtained (OR=5.250)
Conclusion: Based on statistical analysis, it can be concluded that there is no significant association between post-preparation TMSC in infertile men and the success rate of IUI procedures (p > 0.05). The odds ratio (OR) obtained is 5.250 (95% CI 0.799-34.496).
World Health Organization. Infertility [Internet]. WHO. 2023 [cited 2024 Jan 1]. Available from: https://www.who.int/publications/i/item/978920068315
Ombelet W. WHO fact sheet on infertility gives hope to millions of infertile couples worldwide. Facts, views Vis ObGyn. 2020;12(4).
Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015;13(1).
Birowo P, Jelita NK, Sari P, Rasyid N. Hubungan Kadar FSH dengan Gambaran Spermatogenik pada Pasien Azoospermia Berdasarkan Kriteria Johnson. eJournal Kedokteran Indonesia. 2018;5(3).
Persandi. Standarisari Analisa Semen Nasional. 2016.
Hajder M, Hajder E, Husic A. The Effects of Total Motile Sperm Count on Spontaneous Pregnancy Rate and Pregnancy After IUI Treatment in Couples with Male Factor and Unexplained Infertility. Med Arch (Sarajevo, Bosnia Herzegovina). 2016 Feb 1;70(1):39–43.
Yavuzcan A, Yurtçu E, Keyif B. Is There Any Effect of Change in Pre-Wash and Post-Wash Semen Parameters on the Success of Intrauterine Insemination? 2024;4–15.
Qureshi SM, Kafeel S, Bibi R, Mohmand J. Post-wash total motile sperm count a useful predictor in the decision to perform IVF/ICSI in patients with non-male factor infertility. J Shifa Tameer-e-Millat Univ. 2020;3(2).
Hododjojo E, Queljoe E De, Tendean OS. Indikasi Inseminasi Intrauterine Akibat Faktor Pria. J Kedokt Komunitas Dan Trop. 2015;3(3).
Allahbadia GN. Intrauterine Insemination: Fundamentals Revisited. Vol. 67, Journal of Obstetrics and Gynecology of India. 2017.
Muthigi A, Jahandideh S, Bishop LA, Naeemi FK, Shipley SK, O'Brien JE, et al. Clarifying the relationship between total motile sperm counts and intrauterine insemination pregnancy rates. In: Fertility and Sterility. Elsevier Inc.; 2021.
Lemmens L, Kos S, Beijer C, Brinkman JW, van der Horst FAL, van den Hoven L, et al. Predictive value of sperm morphology and progressively motile sperm count for pregnancy outcomes in intrauterine insemination. Fertil Steril. 2016;105(6).
Carlson BM. Chapter 14 - The Reproductive System. In: The Human Body. Academic Press; 2019. p. 373–96.
Linck RW, Chemes H, Albertini DF. The axoneme: the propulsive engine of spermatozoa and cilia and associated ciliopathies leading to infertility. Vol. 33, Journal of Assisted Reproduction and Genetics. 2016.
Hamilton JAM, Cissen M, Brandes M, Smeenk JMJ, De Bruin JP, Kremer JAM, et al. Total motile sperm count: A better indicator for the severity of male factor infertility than the WHO sperm classification system. Hum Reprod. 2015 May 1;30(5):1110–21.
Leslie SW, Soon-Sutton TL KM. Male Infertility [Internet]. StatPearls [Internet]. StatPearls Publishing; 2023 Jan-; 2023 [cited 2023 Mar 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562258/
Charit AB, Sirait BI. Jumlah Sperma Motil yang Memberikan Keberhasilan Tertinggi pada inseminasi Intra Uterin di Morula IVF Jakarta Periode Juni-Oktober 2018. Vol. I, Jurnal Ilmiah WDYA Kesehatan dan Lingkungan. 2020. p. 221–8.
Gnoth C, Johnson S. Strips of hope: Accuracy of home pregnancy tests and new developments. Geburtshilfe Frauenheilkd. 2014;74(7).
Murugan VA, Murphy BO, Dupuis C, Goldstein A, Kim YH. Role of ultrasound in the evaluation of first-trimester pregnancies in the acute setting. Ultrasonography. 2020;39(2).
Nordhoff V, Kliesch S. Sperm preparation for therapeutic IVF. In: Principles of IVF Laboratory Practice: Optimizing Performance and Outcomes. 2017.
Fácio CL, Previato LF, Machado-Paula LA, Matheus PCS, Araújo Filho E. Comparison of two sperm processing techniques for low complexity assisted fertilization: Sperm washing followed by swim-up and discontinuous density gradient centrifugation. J Bras Reprod Assist. 2016;20(4).
Ali AH, Ajina T, Ali M Ben, Mehdi M. Efficacy of density gradient centrifugation technique (DGC) in enhancing sperm cell DNA quality for assisted reproductive technique. Middle East Fertil Soc J. 2022;27(1).
Salim A, Kurniawan Y, Pramesemara IGN. Relationship Between Smoker Male Partner and Intrauterine Insemination Success in Kasih Ibu General Hospital Denpasar. Indones Androl Biomed J. 2021;2(2).
Starosta A, Gordon CE, Hornstein MD. Predictive factors for intrauterine insemination outcomes: a review. Fertil Res Pract. 2020;6(1).
Copyright (c) 2024 I Kadek Sadam Wibawa, I Gusti Ngurah Pramesemara, I Made Oka Negara, I Gusti Ayu Widianti
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
