The Correlation Between Erectile Dysfunction and Coronary Heart Disease in Men at RSUP. Prof. Ngoerah
Background : Coronary heart disease (CHD) has become one of the major economic burdens globally, as CHD has been the leading cause of mortality worldwide for the past 25 to 30 years. One of the factors that plays a role as a predictor of coronary heart disease is erectile dysfunction.
Objective : To investigate the correlation between erectile dysfunction and coronary heart disease in male patients at RSUP Prof. Ngoerah.
Methods : This research is an observational analytic study with a case-control design. Erectile dysfunction was measured using the IIEF-5 questionnaire, which consists of 5 items. Other risk factors were measured using a patient data questionnaire. The study sample consisted of 50 participants, divided into 25 cases and 25 controls. The case samples were male patients aged 25–60 with a history of coronary heart disease who were visiting or receiving treatment at the Cardiology Outpatient Clinic, Integrated Cardiac Services Building, RSUP Prof. Ngoerah, Denpasar. The control samples had the same criteria as the case samples but had no history of coronary heart disease.
Results : A significant relationship was found between erectile dysfunction and coronary heart disease (p=0.049), with an OR of 9.33 (95% CI 1.05–82.8).
Conclusion : There is a significant relationship between erectile dysfunction and coronary heart disease. Patients with erectile dysfunction have a 9.33 times higher likelihood of having coronary heart disease.
Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The Global Burden of Cardiovascular Diseases and Risk. J Am Coll Cardiol. 2022 Dec;80(25):2361–71.
Ralapanawa U, Sivakanesan R. Epidemiology and the Magnitude of Coronary Artery Disease and Acute Coronary Syndrome: A Narrative Review. J Epidemiol Glob Health [Internet]. 2021 Jun 1 [cited 2022 Apr 14];11(2):169. Available from: /pmc/articles/PMC8242111/
Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2013. Kementrian Kesehatan RI. 2013;
Kemenkes RI. Hasil Riset Kesehatan Dasar Tahun 2018. Kementrian Kesehatan RI. 2018;53(9):1689–99.
Brown JC, Gerhardt TE, Kwon E. Vol. 05, StatPearls Publishing. 2021 [cited 2022 Apr 22]. Risk Factors for Coronary Artery Disease. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554410/
Zhao D. Epidemiological Features of Cardiovascular Disease in Asia. JACC: Asia. 2021 Jun 1;1(1):1–13.
Rosendorff C, Lackland DT, Allison M, Aronow WS, Black HR, Blumenthal RS, et al. Treatment of hypertension in patients with coronary artery disease: A scientific statement from the american heart association, american college of cardiology, and american society of hypertension. Circulation [Internet]. 2015 May 12 [cited 2022 Apr 15];131(19):e435–70. Available from: https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000000207
Weber T, Lang I, Zweiker R, Horn S, Wenzel RR, Watschinger B, et al. Hypertension and coronary artery disease: epidemiology, physiology, effects of treatment, and recommendations. Wiener klinische Wochenschrift 2016 128:13 [Internet]. 2016 Jun 9 [cited 2022 Apr 15];128(13):467–79. Available from: https://link.springer.com/article/10.1007/s00508-016-0998-5
Huxley R. Risk factors: Smoking and CAD - What’s plaque got to do with it? Nat Rev Cardiol. 2015;12(5):265–6.
Kondo T, Nakano Y, Adachi S, Murohara T. Effects of tobacco smoking on cardiovascular disease. Circulation Journal. 2019;83(10):1980–5.
Salehi N, Janjani P, Tadbiri H, Rozbahani M, Jalilian M. Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review: https://doi.org/101177/03000605211059893 [Internet]. 2021 Dec 2 [cited 2022 Mar 16];49(12):1–11. Available from: https://journals.sagepub.com/doi/full/10.1177/03000605211059893
Aronson D, Edelman ER. Coronary artery disease and diabetes mellitus. Cardiol Clin [Internet]. 2014;32(3):439–55. Available from: http://dx.doi.org/10.1016/j.ccl.2014.04.001
Olesen KKW, Madsen M, Egholm G, Thim T, Jensen LO, Raungaard B, et al. Patients with diabetes without significant angiographic coronary artery diseasehave the same risk of myocardial infarction as patients without diabetes in a real-world population receiving appropriate prophylactic treatment. Diabetes Care. 2017;40(8):1103–10.
Jahangir E, De Schutter A, Lavie CJ. The relationship between obesity and coronary artery disease. Translational Research [Internet]. 2014;164(4):336–44. Available from: http://dx.doi.org/10.1016/j.trsl.2014.03.010
Mandviwala T, Khalid U, Deswal A. Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker? Curr Atheroscler Rep. 2016;18(5).
Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views [Internet]. 2017 [cited 2022 Mar 15];18(3):109. Available from: /pmc/articles/PMC5686931/
Helgadottir A, Gretarsdottir S, Thorleifsson G, Hjartarson E, Sigurdsson A, Magnusdottir A, et al. Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. Nat Genet. 2016;48(6):634–9.
Pérez-Méndez Ó, Pacheco HG, Martínez-Sánchez C, Franco M. HDL-cholesterol in coronary artery disease risk: Function or structure? Clinica Chimica Acta [Internet]. 2014;429:111–22. Available from: http://dx.doi.org/10.1016/j.cca.2013.12.001
Madhavan M V., Gersh BJ, Alexander KP, Granger CB, Stone GW. Coronary Artery Disease in Patients ≥80 Years of Age. J Am Coll Cardiol [Internet]. 2018 May 8 [cited 2022 Apr 19];71(18):2015–40. Available from: https://www.jacc.org/doi/10.1016/j.jacc.2017.12.068
Nakazato R, Arsanjani R, Achenbach S, Gransar H, Cheng VY, Dunning A, et al. Age-related risk of major adverse cardiac event risk and coronary artery disease extent and severity by coronary CT angiography: results from 15 187 patients from the International Multisite CONFIRM Study. Eur Heart J Cardiovasc Imaging [Internet]. 2014 May 1 [cited 2022 Apr 19];15(5):586–94. Available from: https://academic.oup.com/ehjcimaging/article/15/5/586/2399607
Mudyawati Kamaruddin, Nurhidayat Triananinsi, Nurqalbi Sampara, Sumarni, Minarti AMR. Media kesehatan masyarakat. Media Kesehatan Masyarakat [Internet]. 2020;16(1):116–26. Available from: https://ejurnal.undana.ac.id/MKM/
Kapoor R, Kapoor A. Erectile dysfunction: A present day coronary disease risk equivalent. Indian Journal of Medical Research. 2016;144(September):307–10.
Birowo P, Deswanto IA, Rasyid N. Epidemiology of erectile dysfunction: A cross-sectional web-based survey conducted in an Indonesian national referral hospital. F1000Research 2019 8:817 [Internet]. 2019 Jun 7 [cited 2022 Mar 31];8:817. Available from: https://f1000research.com/articles/8-817
Desai M, Naik G, Kamat US, Cacodcar JA. Concurrence of erectile dysfunction and coronary artery disease among patients undergoing coronary angiography at a tertiary Medical College Hospital in Goa. Indian Heart J. 2020 Mar;72(2):123–5.
Mohamed Abd Elsamie I, Abou Khodair H, Bashandy MS, Aboelwafa H. Prevalence of Erectile Dysfunction among Patients with Coronary Artery Disease. Andrologia. 2024 Mar 25;2024:1–10.
Vasiliki C, Fedra Zoi K, Omar E, Rasha E, Joseph A M. Prevalence of Hypertension in patients with chronic Coronary Artery Disease in Cyprus. Annals of Clinical Hypertension. 2022 Dec 6;6(1):015–9.
Xue H, Wang C, Xin Q. PREVALENCE AND CLINICAL CHARACTERISTICS OF COMORBID HYPERTENSION AND CORONARY ARTERY DISEASE IN CHINA, 2008-2018. J Hypertens. 2024 May;42(Suppl 1):e121.
Chen Y, Zhou ZF, Han JM, Jin X, Dong ZF, Liu L, et al. Patients with comorbid coronary artery disease and hypertension: a cross-sectional study with data from the NHANES. Ann Transl Med. 2022 Jul;10(13):745.
Mak KH, Vidal-Petiot E, Young R, Sorbets E, Greenlaw N, Ford I, et al. Prevalence of diabetes and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities. Eur J Prev Cardiol. 2022 Jan 11;28(16):1795–806.
Shrivastav D, Dabla PK, Singh DD, Mehta V. Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study. Explor Med. 2023 Jun 28;336–42.
Hartopo AB, Inggriani MP, Jhundy BW, Fachiroh J, Rosha PT, Wardani RK, et al. Modifiable risk factors for coronary artery disease in the Indonesian population: a nested case-control study. Cardiovascular Prevention and Pharmacotherapy. 2023 Jan 31;5(1):24–34.
Oshunbade AA, Kassahun‐Yimer W, Valle KA, Hamid A, Kipchumba RK, Kamimura D, et al. Cigarette Smoking, Incident Coronary Heart Disease, and Coronary Artery Calcification in Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2021 Apr 6;10(7).
Reda AA, Soliman MA, Elkersh AM, Yousef SR. Prevalence of Cardiovascular Risk Factors and Heterozygous Familial Hypercholesterolemia in Premature Atherosclerotic Patients Presenting with Acute Coronary Syndrome. World J Cardiovasc Dis. 2021;11(03):195–209.
Kumar Bariha P, Chandra Karua P, Mohapatra MK. A Cross Sectional Study on Clinical Profile, Risk Factors, and Outcome of Patients with Coronary Artery Disease in Western Odisha. Original Research Article J Evid Based Med Healthc. 2021;8:2349–562.
Held C, Hadziosmanovic N, Aylward PE, Hagström E, Hochman JS, Stewart RAH, et al. Body Mass Index and Association With Cardiovascular Outcomes in Patients With Stable Coronary Heart Disease – A STABILITY Substudy. J Am Heart Assoc. 2022 Feb;11(3).
Hamur H, Duman H, Keskin E, Inci S, Kucuksu Z, Degirmenci H, et al. The relation between erectile dysfunction and extent of coronary artery disease in the patients with stable coronary artery disease. Int J Clin Exp Med. 2015;8(11):21295–302.
Sayadi M, Elmafshar R, Razeghian-Jahromi I, Zibaeenezhad MJ. Detection of Coronary Artery Disease by an Erectile Dysfunction Questionnaire. Cardiol Res Pract. 2021 Mar 13;2021:1–6.
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