PROPORTION OF HBsAg AND HBeAg POSITIVE IN MATERNAL PATIENTS AND THEIR HBsAg POSITIVES BABIES WITH IMMUNOPROPHYLAXIS OF HBV IMMUNIZATION IN Dr. SOETOMO GENERAL HOSPITAL, SURABAYA
Hepatitis B Virus (HBV) can be transmitted vertically from mother to her baby. Mothers with HBsAg and HBeAg positives have more risk of transmitting HBV to her baby rather than HBsAg positives only. The aim of this study is to determine the proportion of maternal patient with HBsAg and HBeAg positives and their HBsAg positives babies with immunoprophylaxis of HBV immunization. This study was performed by analytical observation using medical records in 2013-2014 at Obstetric and Gyn ecology Department, Dr. Soetomo Hospital. The samples were all maternal patients (3796) during that period and also their babies from HBsAg positives mothers. Unfortunately, several original medical records were not available. Thirty two (0,85%) out of 3781 maternal patients were found to be HBsAg positives, and three (9,37%) of 32 patients with HBsAg positives were HBeAg positives. From 32 mothers who were positive HBsAg, 22 complete medical records of their babies were found and all of them (100%) had been given Hepatitis B Immunoglobulin (HBIG) and hepatitis B vaccine less than twelve hours after birth. In three cases of the babies from HBeAg positives mothers which had been given prophylaxis properly, two cases each of which was with caesarean and spontaneous delivery were HBsAg negatives. Interestingly, the other one which born with spontaneous delivery was found to be HBsAg positives. Further study in this HBsAg positives baby, especially in analyzing its HBV DNA is needed. The epidemiology of hepatitis B in maternal patients, especially that with complete and neat data needs further research.
Riset Kesehatan Dasar [Internet]. Badan Penelitian Dan Pengembangan Kesehatan Kementerian Kesehatan RI. 2013. Available from: http://www.depkes.go.id/resources/download/general/Hasil Riskesdas2013.pdf
DF de PM, T M, DJ T, RA VES, JL N-S, F ST, et al. Prevalence and factors associated with hepatitis B virus infection among senior citizens in a southern brazilian city. Hepat Mon. 2013;13(5).
Kusumawati L, Mulyani NS, Pramono D. Faktor-Faktor yang Berhubungan dengan Pemberian Imunisasi Hepatitis B 0-7 Hari. Ber Kedokt Masy. 2007;23(1):21–7.
Hepatitis B Are You at Risk? Vol. 21, DEPARTMENT OF HEALTH & HUMAN SERVICES Centers for Disease Control and Prevention. 2010.
Lusida MI, Sakugawa H, Nagano-fujii M, Handajani R, Setiawan PB, Nidom CA, et al. Genotype and Subtype Analyses of Hepatitis B Virus ( HBV ) and Possible Co-Infection of HBV and Hepatitis C Virus ( HCV ) or Hepatitis D Virus ( HDV ) in Blood Donors , Patients with Chronic Liver Disease and Patients on Hemodialysis in Surabaya , Indones. Microbiol Immunol. 2003;47(12):969–75.
Soemoharjo S. Hepatitis Virus B Edisi 2. Ed. 2 Cet. Jakarta: EGC; 2008.
Ashraf H, Alam NH, Rothermundt C, Brooks A, Bardhan P, Hossain L, et al. Prevalence and Risk Factors Of Hepatitis B and C Virus Infections in An Impoverished Urban Community in Dhaka, Bangladesh. BMC Infect Dis. 2010;10(208):1–8.
Indonesia DKR. Pedoman Pengendalian Hepatitis Virus. Jakarta: Kementrian Kesehatan RI; 2012.
Hepatitis B Epidemiology and Prevention of Vaccine-Preventable Diseases [Internet]. Centers for Disease Control and Prevention. 2012. Available from: https://www.cdc.gov/vaccines/pubs/pinkbook/hepb.html
Hepatitis B [Internet]. World Health Organization. 2002. Available from: http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf
Horn T, Learned J. Hepatitis Virus dan HIV. AIDS Community Research Initiative of America (ACRIA); 2005.
Bhatt CP. Prevalence of viral Hepatitis B in BPKIHS Dharan, Nepal. J Nepal Med Assoc. 2000;39:281–3.
Memish ZA, Knawy B Al, El-Saed A. Incidence trends of viral
hepatitis A, B, and C seropositivity over eight years of surveillance in Saudi Arabia. Int J Infect Dis. 2010;14(2):115-20.
MS C, S G, PC A, J M-B. Caesarean section to prevent transmission of hepatitis B: A meta-analysis. Can J Gastroenterol Hepatol. 2014;8(8):439–44.
MM J. Hepatitis B and Pregnancy: an underestimated issue. Liver Int. 2009;29(S1):133–9.
Aghamohammadi A, Nooritajer M. Maternal Hbsag Carrier and Pregnancy Outcome. Aust J Basic Appl Sci. 2011;5(3):607–10.
S W, LY C, V Y, Ho L. Hepatitis B carrier and perinatal outcome in singleton pregnancy. Am J Perinatol. 1999;16(9):485–8.
Ikeako L, Ezegwui H, Ajah L, Dim C, Okeke T. Seroprevalence of Human Immunodeficiency Virus, Hepatitis B, Hepatitis C, Syphilis and Co-infections among Antenatal Women in a Tertiary Institution in South-East Nigeria. Ann Med Health Sci Res. 2014;4(6):954–8.
Cooreman MP, Leroux-Roels G, Paulij WP. Vaccine- and Hepatitis B Immune Globulin-Induced Escape Mutations of Hepatitis B Virus Surface Antigen. J Biomed Sci. 2001;8(3):237–47.
Zou H, Chen Y, Duan Z, Zhang H, Pan C. Virologic factors associated with failure to passive–active immunoprophylaxis in infants born to HBsAg-positive mothers. J Viral Hepat. 2011;19(2):e18–25.
The Indonesian Journal of Tropical and Infectious Disease (IJTID) is a scientific peer-reviewed journal freely available to be accessed, downloaded, and used for research. All articles published in the IJTID are licensed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which is under the following terms:
Attribution — You must give appropriate credit, link to the license, and indicate if changes were made. You may do so reasonably, but not in any way that suggests the licensor endorses you or your use.
NonCommercial — You may not use the material for commercial purposes.
ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.