Natural Growth Factor: Platelet Rich Plasma Stimulates Proliferation of Fibroblast Cell Culture

Ernie Maduratna Setiawati

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Platelet rich plasma(PRP) is a source of many natural growth factor that can modulate wound healing. PRP has become a  valuable adjunct in dentistry. Fibroblast cell in ligament periodontal play on important role in periodontal regeneration. The study was performed to investigate the influence PRP 10%–100% on the proliferation of fibroblast cell culture in vitro. A fibroblast culture was estabilished from baby hamster kidney (BHK-21) were tested on proliferation was measured with MTT assay after induced PRP 10–100%. We showed that PRP stimulate the proliferation of fibroblast, PRP 80% as the optimal choice to a good enough proliferative stimulus. PRP has proven to be effective at improving surgical results in periodontal surgery. PRP also show promise in periodontal regenerative medicine.


PRP, natural growth factor, proliferation of fibroblast

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Lembaga Penyakit Tropis (Institute of Tropical Disease)

Universitas Airlangga

Kampus C Mulyorejo

Surabaya 60115