Association of IL – 23 R rs 7518660 Gene Polymorphism with Susceptibility and Disease Severity of Pulmonary Tuberculosis
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Pulmonary Tuberculosis (TB) is a global health problem. Of all people infected with Mycobacterium tuberculosis only a small proportion develops into TB. IL 23 is the key cytokine in the pathogenesis of TB infection. This study aims to determine the association of IL-23 R rs 7518660 gene polymorphism with susceptibility and disease severity of Pulmonary TB. A case control study involved 105 people consisting of 31 drug sensitive pulmonary TB patients, 40 patients with drug-resistant pulmonary TB and 34 healthy subjects as a control. IL-23 R rs 7518660 gene polymorphism G allele increases susceptibility to both TB drug-sensitive and drug-resistant. G and A allele, AA and AG genotypes indicates (p value >0.05) in correlation with disease severity based on lesion in chest x-ray and high load of Mycobacterium tuberculosis in sputum. There was a significant relationship between allele A and susceptibility to pulmonary TB with an odds ratio of 0.231. It showed that patients with A alleles (AG and AA genotypes) were at risk of developing TB by 1/0.231 = 4.33 times lower than patients with GG genotypes. Meanwhile, the relationship of the G allele with susceptibility to pulmonary TB obtained (p value <0.05) and an odds ratio value of 0.127 indicating that patients with G alleles (GG and AG genotypes) were at risk of developing TB of 1/0.127 = 7.87 times higher than in patients with the AA genotype. Conclusion: We found significant correlation between IL-23 R rs 7518660 gene polymorphism G allele with susceptibility to pulmonary TB, but the result was not significant with disease severity.
WHO. Global Tuberculosis Reports. Published online 2020.
Boisson-Dupuis S, Ramirez-Alejo N, Li Z, et al. Tuberculosis and impaired IL-23–dependent IFN- immunity in humans homozygous for a common TYK2 missense variant. Sci Immunol. 2018;3(30).
Indonesia KKR. Petunjuk Teknis Penanganan Infeksi Laten Tuberkulosis (ILTB). Published online 2020.
Rapolu BL, Pullagurla A, Ganta S, Komaravalli PL, Gaddam SL. Immuno-genetic importance of Th17 in susceptibility to TB. Scand J Immunol. 2021;94(2):1-7.
Butov DO, Kuzhko MM, Makeeva NI, Butova TS, Stepanenko HL, Dudnyk AB. Association of interleukins genes polymorphisms with multi-drug resistant tuberculosis in Ukrainian population. Adv Respir Med. 2016;84(1):168-173.
Palomino JC, Martin A. Drug resistance mechanisms in Mycobacterium tuberculosis. Antibiotics. 2014;3(3):317-340.
Prasetya. Faktor-faktor Yang Berpengaruh Terhadap Keberhasilan Pengobatan Paduan Standar Jangka Pendek Pasien TB Resisten Obat (TB RO) di RSU dr Saiful Anwar Malang. Published online 2019.
Yani Jane S, Enggar Fitri L, Susianti H, Reto Prawiro S. Increasing of IL-17 and IL-23 levels in Acid-Fast Bacilli Conversion of Drug Resistant Tuberculosis Patients after One Month Treatment. SysrevpharmOrg. 2021;12(1):771-780.
Jiang D, Wubuli A, Hu X, et al. The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs. BMC Infect Dis. 2015;15(1):1-10.
Floss DM, Moll JM, Scheller J. IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions. Cells. 2020;9(10):1-24.
Sary M, Muhammad M, Saleh I. Hubungan Polimorfisme Gen XRCC1 Arg 399 Gln terhadap Kejadian Kanker Serviks pada Wanita Ras Melayu 2018;4(1):1-8.
Miggiano R, Rizzi M, Ferraris DM. Mycobacterium tuberculosis pathogenesis, infection prevention and treatment. Pathogens. 2020;9(5):10-13.
Seid G, Ayele M. Undernutrition and Mortality among Adult Tuberculosis Patients in Addis Ababa, Ethiopia. Adv Prev Med. 2020;2020:1-9.
Singh DP, Bagam P, Sahoo MK, Batra S. Immune-related gene polymorphisms in pulmonary diseases. Toxicology. 2017;383:24-39.
Floss DM, Schröder J, Franke M, Scheller J. Insights into IL-23 biology: From structure to function. Cytokine Growth Factor Rev. 2015;26(5):569-578.
Khalilullah SA, Harapan H, Hasan NA, Winardi W, Ichsan I, Mulyadi M. Host genome polymorphisms and tuberculosis infection: What we have to say? Egypt J Chest Dis Tuberc. 2014;63(1):173-185.
Thorson AE. Gender differences in tuberculosis. Int J Infect Dis. 2014;21:65-66.
Urdahl KB, Shafiani S, Ernst JD. Initiation and regulation of T-cell responses in tuberculosis. Mucosal Immunol. 2011;4(3):288-293.
Khader SA, Guglani L, Rangel-Moreno J, et al. IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung . J Immunol. 2011;187(10):5402-5407.
Hunter RL. Tuberculosis as a three-act play: A new paradigm for the pathogenesis of pulmonary tuberculosis. Tuberculosis. 2016;97:8-17.
Yannam GR, Gutti T, Poluektova LY. IL-23 in infections, inflammation, autoimmunity and cancer: Possible role in HIV-1 and AIDS. J Neuroimmune Pharmacol. 2012;7(1):95-112.
Dodd PJ, Sismanidis C, Seddon JA. Global burden of drug-resistant tuberculosis in children: a mathematical modelling study. Lancet Infect Dis. 2016;16(10):1193-1201.
Icksan A.G, Napitupulu M.R, Nawas M.A and NF. Chest X-ray findings comparison between multi-drug-resistant Tuberculosis and Drug-sensitive tuberculosis. Published online 2018.
Blakemore R, Nabeta P, Davidow AL, et al. A multisite assessment of the quantitative capabilities of the Xpert MTB/RIF assay. Am J Respir Crit Care Med. 2011;184(9):1076-1084.
Ben-Selma W, Boukadida J. IL23R(Arg381Gln) functional polymorphism is associated with active pulmonary tuberculosis severity. Clin Vaccine Immunol. 2012;19(8):1188-1192.
Governorate G. Smear Positive Versus Smear Negative Tuberculosis: An Audit of Some Aspect Related to Management Practices in Mahalla Al-Kobra Chest Hospital, Gharbia Governorate, Egypt. Egypt J Community Med. 2015;33(3):1-18.
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