NO ASSOCIATION OF RECURRENT RESPIRATORY PAPILLOMATOSIS AGGRESSIVENESS AND HUMAN PAPILLOMAVIRUS TYPE 6 AND 11

Rizka Fathoni Perdana, Sri Herawati, Bakti Suroso, Eduardus Bimo Aksono

= http://dx.doi.org/10.20473/ijtid.v6i5.3705
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Abstract


Recurrent Respiratory Papillomatosis (RRP) is the most common benign neoplasm of the larynx among children as a result of HPV infection mainly type 6 and 11. RRP is still considered as serious problem since papilloma in the airway can cause hoarseness and obstruction which later described as aggressive and non aggressive types. Patients underwent multiple surgeries to keep airway patency and in order to communicate vocally. Previous studies reported that HPV-11 was associated with a more aggressive disease course. This study aim is to determine the association of RRP aggressiveness with HPV-6 and 11. Papilloma specimens were taken from patients who underwent surgical treatment of RRP patients and subjected HPV typing. All 17 patients with completed data and epidemiologic questionaires were defined for their staging to disease severity. Informations in the database were analyzed to identity statistically significant relationship with HPV type and knowing the HPV type is to predict the disease course. 17 patients RRP (12 males and 5 females) with age at onset 3,15 + 2,28 years and age at diagnosis 3,81 + 2,51 years. Surgery was performed 2,71 ± 1,16 times per year and 9 patients treated more than 3 surgeries per year. 10 patients had distal papilloma and 11 patients had tracheotomy. Agrressive disease was show found in 14 patients among 17 patients. HPV-11 was detected in 10 patients, HPV-6 was detected in 7 patients. According to the statisitcal analysis (Chi square test), there is no relationship between HPV type and disease aggressiveness. HPV-6 and 11 are not the only cause that affect the aggressiveness of Recurrent Respiratory Papillomatosis.


Keywords


Papilloma; recurrent papillomatosis; respiratory papillomatosis; human papilloma virus; juvenile papillomatosis; adult papillomatosis

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References


Ganguly N, Parihar SP. Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis. J Biosci. 2009 Mar;34(1):113–23.

Ghittoni R, Accardi R, Hasan U, Gheit T, Sylla B, Tommasino M. The biological properties of E6 and E7 oncoproteins from human papillomaviruses. Virus Genes. 2010 Feb;40(1):1–13.

Larson DA, Derkay CS. Epidemiology of recurrent respiratory papillomatosis. APMIS. 2010 Jun;118(6–7):450–4.

Derkay CS, Darrow DH. Seminar Series Recurrent Respiratory Papillomatosis. Ann Otol Rhinol Laryngol. 2006 Jan 29;115(1):1-11.

Tasca RA, Clarke RW. Recurrent respiratory papillomatosis. Arch Dis Child. 2006 Aug;91(8):689–91.

Andrus JG, Shapshay SM. Contemporary management of laryngeal papilloma in adults and children. Otolaryngol Clin North Am. 2006;39(1):135–58.

Derkay CS, Faust RA. Recurrent respiratory papillomatosis In Cummings Otolaryngology – Head and Neck Surgery. 5th ed. Philadelphia: Mosby; 2010. 2884-95 p.

Stamataki S, Nikolopoulos TP, Korres S, Felekis D, Tzangaroulakis A, Ferekidis E. Juvenile recurrent respiratory papillomatosis: still a mystery disease with difficult management. Head Neck. 2007 Feb;29(2):155–62.

Xue Q, Wang H, Wang J. Recurrent respiratory papillomatosis: an overview. Eur J Clin Microbiol Infect Dis. 2010 Sep;29(9):1051–4.

Derkay CS, Wiatrak B. Recurrent respiratory papillomatosis: a review. Laryngoscope. 2008 Jul;118(7):1236–47.

Buchinsky FJ, Donfack J, Derkay CS, Choi SS, Conley SF, Myer CM, et al. Age of Child, More than HPV Type, Is Associated with Clinical Course in Recurrent Respiratory Papillomatosis. Kallas EG, editor. PLoS One. 2008 May 28;3(5):e2263.

Wiatrak BJ, Wiatrak DW, Broker TR, Lewis L. Recurrent respiratory papillomatosis: a longitudinal study comparing severity associated with human papilloma viral types 6 and 11 and other risk factors in a large pediatric population. Laryngoscope. 2004 Nov;114(11 Pt 2 Suppl 104):1–23.

Campisi P, Hawkes M, Simpson K, Canadian Juvenile Onset Recurrent Respiratory Papillomatosis Working Group. The epidemiology of juvenile onset recurrent respiratory papillomatosis derived from a population level national database. Laryngoscope. 2010 Jun;120(6):1233–45.

Maloney EM, Unger ER, Tucker RA, Swan D, Karem K, Todd NW, et al. Longitudinal Measures of Human Papillomavirus 6 and 11 Viral Loads and Antibody Response in Children With Recurrent Respiratory Papillomatosis. Arch Otolaryngol Neck Surg. 2006 Jul 1;132(7):711–5.

Bonagura VR, Vambutas A, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, et al. HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis. Hum Immunol. 2004 Aug;65(8):773–82.


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