Viral Infection

The Effect of C-Reactive Protein Levels, Neutrophil, and Lymphocyte Count to Mortality of COVID-19 Patients with Sepsis in Referral Hospital

COVID-19 Sepsis CRP Neutrophils Lymphocytes



Coronavirus disease 2019 (COVID-19) is an infectious disease caused by infection of Severe Acute Respiratory
Distress Syndrom Coronavirus-2 (SARS CoV-2). COVID-19 patients may develop sepsis, the disregulation of
the immune system that causes organ dysfunction and life-threatening situations. High mortality of COVID-19
and sepsis make it important to study. The purpose of this study is to analyze the effect of CRP levels, neutrophil,
and lymphocyte count to mortality of COVID-19 patients with sepsis. This study is an analytic observational study
with a cross-sectional approach. Samples were randomly retrieved of COVID-19 patients with sepsis admitted
in referral hospital. Univariate, bivariate, and multivariate analysis used SPSS 26th version of Windows. The
results of this study indicate a significant effect of CRP levels and neutrophil count on mortality of COVID-19
patients with sepsis. Meanwhile, lymphocyte count had no significant effects. The multivariate analysis showed
its significance value. Partially, the effect of neutrophils on the patient's mortality has a significant value. The
conclusion of this study is CRP levels and neutrophil count simultaneously have an effect on higher mortality of
COVID-19 patients with sepsis.