Detection of Potentially Inappropriate Medication in Elderly Outpatient Based on The Beer's Criteria 2019
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Background: Elderly patients generally have more than one disease, so they need several drugs to treat the condition and Potentially Inappropriate Medication (PIM). Objective: This study aimed to examine the inaccuracy of prescription drugs in the elderly using Beer's criteria 2019. Methods: The research method used an observational study with a descriptive cross-sectional design. Beer's Criteria 2019 was compiled by The American Geriatrics Society (AGS) and grouped PIM into five categories. A total of 138 prescriptions met the inclusion criteria at the Internal Medicine Clinic. Results: The results showed that the elderly who received the prescription was in the age range of 60-69 years (73.2%), male gender (54%), and had comorbidity (77.5%). Of the 138 prescriptions for elderly patients, 117 prescriptions for elderly patients experienced PIM incidence (84.78%). The percentage of PIM incidents was based on categories; namely, category 1 was 74.2%, category 2 was 3.5%, 3 was 16.7%, category 4 was 3%, and category 5 was 2.5%. Medicines that include PIM in category 1 are lansoprazole, glimepiride, glibenclamide, alprazolam, diazepam, amitriptyline, diclofenac sodium, ibuprofen, meloxicam. PIM in category 2 are cilostazol, pioglitazone, and diclofenac sodium. Category 3 PIMs include furosemide, spironolactone, and hydrochlorothiazide (HCT), category 4 PIMs include dexamethasone-sodium diclofenac, methylprednisolone-ibuprofen, and alprazolam-codeine, and category 5 PIMs include spironolactone, ciprofloxacin, and ranitidine.. Conclusion: This study concludes that the elderly are at risk for receiving inappropriate drug prescriptions. Patients received more drugs belonging to category 1 PIM than category 2, 3, 4, and 5.
Abdulah, R. & Barliana, M. I. (2015). Potentially Inappropriate Medication Use for Geriatric Population in Bandung City. Indonesian Journal of Clinical Pharmacy; 4; 226–233. doi: 10.15416/ijcp.2015.4.3.226.
American Geriatrics Society. (2019). American Geriatrics Society 2019 Updated AGS Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. Journal of the American Geriatrics Society; 67; 1-21. doi: 10.1111/jgs.15767.
Astuti, S. D., Lubis, N. D. & Kurniasari, F. (2017). Evaluasi Ketidaktepatan Pemilihan Obat Berdasarkan Kriteria STOPP Pada Pasien Geriatri. Jurnal Farmasi Indonesia; 14; 182–190. doi: 10.31001/jfi.v14i2.347.
Badan Pusat Statistik. (2018). Statistik Penduduk Lanjut Usia. Jakarta: Badan Pusat Statistik.
Badan Pusat Statistik. (2020). Statistik Penduduk Lanjut Usia 2020. Jakarta: Badan Pusat Statistik.
Bird, S. T., Etminan, M., Brophy, J. M., Hartzema, A. G. & Delaney, J. A. C. (2013). Risk of Acute Kidney Injury Associated with the Use of Fluoroquinolones. Canadian Medical Association Journal; 185; 475–482. doi: 10.1503/cmaj.121730.
Darke, S. G., Ross, J. & Teesson, M. L. M. (2003). Health Service Utilization And Benzodiazepine Use Among Heroin Users: Findings From the Australian Treatment Outcome Study (ATOS). Drug Alcohol Depend; 98; 1129–1135. doi: 10.1046/j.1360-0443.2003.00430.x.
Fakultas Kedokteran Universitas Sriwijaya. (2004). Kumpulan Kuliah Farmakologi. Jakarta: EGC.
Food and Drug Administration. (2009). Food Safety. Silver Spring: FDA.
Food and Drug Administration. (2011). Drug Safety Communication: Low Magnesium Levels Can be Associated with Long-term Use of Proton Pump Inhibitor drugs (PPIs). Silver Spring: FDA.
Gumantara, M. P. B. & Oktarlina, R. Z. (2017). Perbandingan Monoterapi dan Kombinasi Terapi Sulfonilurea-Metformin terhadap Pasien Diabetes Melitus Tipe 2. Majority; 6; 55–59.
Handajani, A., Roosihermiatie, B. & Maryani, H. (2010). Faktor-Faktor yang Berhubungan dengan Pola Kematian pada Penyakit Degeneratif di Indonesia. Buletin Penelitian Sistem Kesehatan; 13; 42–53.
Holt, S., Schmiedl, S. & Thürmann, P. A. (2010). Potentially Inappropriate Medications in the Elderly: The PRISCUS List. Deutsches í„rzteblatt International; 107; 543–551. doi: 10.3238/arztebl.2010.0543.
Jones, J. D., Mogali, S. & Comer, S. D. (2013). Polydrug Abuse: a Review of Opioid and Benzodiazepine Combination Use. Drug Alcohol Depend; 125; 8–18. doi: 10.1016/j.drugalcdep.2012.07.004.
Kementerian Kesehatan Republik Indonesia. (2013). Gambaran Kesehatan Lanjut Usia di Indonesia. Jakarta: Kementerian Kesehatan Republik Indonesia.
Kementerian Kesehatan Republik Indonesia. (2014). Situasi dan Analisis Lanjut Usia. Jakarta: Pusat Data dan Informasi Kementrian Kesehatan Republik Indonesia.
Lacy, C. F., Armstrong, L. L., Goldman, M. P. & Lance L. L. (2009). Drug Information Handbook, 17th Ed. Washington, DC: American Pharmacists Association.
Lovell, A. R., & Ernst, M. E. (2017). Drug-Induced Hypertension: Focus on Mechanisms and Management. Current Hypertension Reports; 19; 1–12. doi: 10.1007/s11906-017-0736-z.
Lutfiyati, H., Yuliastuti, F. & Khotimah, A. (2017). Pola Pengobatan Hipertensi Pada Pasien Lansia Di Puskesmas Windusari Kabupaten Magelang. Jurnal Farmasi Sains dan Praktis; 3; 14–18. doi: 10.31603/pharmacy.v3i2.1726.
Marinda, F. D., Suwandi, J. F. & Karyus, A. (2016). Pharmacologic Management of Diabetes Mellitus Type 2 in Elderly Woman with Uncontrolled Blood Glucose. Jurnal Medula Unila; 5; 26–32.
Moore, N., Pollack, C. & Butkerait, P. (2015). Adverse Drug Reactions And Drug–Drug Interactions with Over-The-Counter NSAIDs. Therapeutics and Clinical Risk Management; 11; 1061–1075. doi: 10.2147/TCRM.S79135.
Mulyani, T., & Rukminingsih, F. (2020). Evaluasi Peresepan pada Pasien Geriatri di Klinik Penyakit Dalam Instalasi Rawat Jalan RSUD K.R.M.T Wongsonegoro Semarang. Jurnal Riset Kefarmasian Indonesia; 2; 89-96. doi: 10.33759/jrki.v2i2.82.
Negara, Y. R., Machlaurin, A., & Rachmawati, E. (2016). Potensi Penggunaan Obat yang Tidak Tepat pada Peresepan Pasien Geriatri Rawat Jalan di RSD dr. Soebandi Jember Berdasarkan Beers Criteria. e-Jurnal Pustaka Kesehatan; 4; 14–19.
Pahwa, R., Sharma, S., Kumar, V. & Kohli, K. (2016). Ranitidine Hydrochloride: An Update On Analytical, Clinical And Pharmacological Aspects. Journal of Chemical and Pharmaceutical Research; 8; 70–78.
Pham, P. C. T., Toscano, E., Pham, P. M. T., Pham, P. A. T., Pham, S. V. & Pham, P. T. T. (2009). Pain Management In Patients With Chronic Kidney Disease. NDT Plus; 2; 111–118. doi: 10.1093/ndtplus/sfp001.
Rahmawati, F., Mustafidah, N. & Annisa, L. (2019). Prevalensi Penggunaan Fall Risk Medicine pada Pasien Lanjut Usia di Instalasi Rawat Jalan Rumah Sakit Madiun. Journal of Management and Pharmacy Practice; 9; 135–142. doi: 10.22146/jmpf.45206.
Rudolph, J. L., Salow, M. J., Angelini, M. C. & McGlinchey, R. E. (2008). The Anticholinergic Risk Scale and Anticholinergic Adverse Effects in Older Persons. Archives of Internal Medicine; 168; 508–513. doi: 10.1001/archinternmed.2007.106.
Setyowati, D., Sudarso., & Utaminingrum, W. (2011). Evaluasi Pola Peresepan Berdasarkan Beers Criteria Pada Pasien Geriatri Rawat Jalan Pada Poli Penyakit Dalam di RSUD Prof. Dr. Margono Soekarjo Purwokerto Periode Agustus 2010-Maret 2011. Pharmacy; 8; 26–27. doi: 10.30595/pji.v8i03.1127
Shinohara, Y. (2010). Factors Affecting Health-Related Quality of Life Assessed with The SF-36v2 Health Survey In Outpatients with Chronic-Stage Ischemic Stroke In Japan - Cross-Sectional Analysis of the OASIS Study. Cerebrovascular Diseases; 29; 361–371. doi: 10.1159/000281834.
Suga, T., Takenoshita, M., Watanabe, T., Tu, T. T. H., Mikuzuki, L., Hong, C., Miura, K., Yoshikawa, T., Nagamine, T. & Toyofuku, A. (2019). Therapeutic Dose of Amitriptyline for Older Patients with Burning Mouth Syndrome. Neuropsychiatric Disease and Treatment; 15; 3599–3607. doi: 10.2147/NDT.S235669.
Sukmawati, S., Kosman, R. & Damayanti, I. (2016). Identifikasi Penggunaan Obat Pada Pasien Hipertensi Usia Lanjut Dengan Beer's Criteria di Instalasi Rawat Inap Rumah Sakit Ibnu Sina Makassar Periode Tahun 2012. As-Syifaa Jurnal Farmasi; 8; 52–58. doi: 10.33096/jifa.v8i1.151.
Supadmi, W. & Hakim, L. (2012). Kaitan Penggunaan Obat Analgetik dan Anti Inflamasi Non Steroid dengan Kejadian Gagal Ginjal Kronik pada Pasien Hemodialisis di RSU PKU Muhammadiyah Yogyakarta. Jurnal Ilmiah Farmasi; 9; 1-8. doi: 10.20885/jif.vol9.iss2.art2.
Suryatenggara, A. N., & Astrawinata, D. A. W. (2018). Sindrom Hormon Antidiuretik Berlebih. Indonesian Journal of Clinical Pathology and Medical Laboratory; 18; 134–140. doi: 10.24293/ijcpml.v18i2.1013.
Tamher, S. N. (2009). Kesehatan Usia Lanjut dengan Pendekatan Asuhan Keperawatan. Jakarta: Salemba Medika.
Tjokroprawiro, A. (2015). Buku Ajar Ilmu Penyakit Dalam. Surabaya: UNAIR Press.
Utami, P., Cahyaningsih, I., & Setiawardani, R. M. (2016). Identification of Drug Related Problems in Congestive Heart Failure Patients in Hospital During January to June 2015. Jurnal Farmasi Sains dan Praktis; 4; 37–43.
Walsh, T. (1997). Kapita Selekta Penyakit dan Terapi. Jakarta: Penerbit Buku Kedokteran EGC.
World Health Organization. (2002). Active Ageing, a Policy Framework. Madrid: World Health Organization.
Yu, E. W., Bauer, S. R., Bain, P. A. & Bauer, D. (2011). Proton Pump Inhibitors and Risk of Fractures: a Meta-Analysis of 11 International Studies. American Journal of Medicine; 124; 519–526. doi: 10.1016/j.amjmed.2011.01.007.
Yuliawati, Krisdawati, Sutrisno, D. & Yulion, R. (2020). Potentially Inappropriate Medication Use in Geriatric Patients Based on 2015 Beers Criteria. SCIENTIA Jurnal Farmasi dan Kesehatan; 10; 70–76. doi: 10.36434/scientia.v10i1.217.
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