Effect Vinyl Chloride to DNA Methylation: A Systematic Review
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Background: Vinyl chloride (VC) is a toxic chemical hazard which is characterized with colorless gas widely used in the plastics manufacturing industry. Vinyl chloride (VC) has various health threatening effects such as bothering deoxyribonucleic acid (DNA) methylation that can cause hepatocellular carcinoma (HCC) and cancer.
Objectives: The purpose of writing systematic review is to determine the effect vinyl chloride (VC) to deoxyribonucleic acid (DNA) methylation.
Methods: The research design is a systematic review article using PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. This question is structured by taking into account 4 stages, namely: Population, Intervention, Comparison, and Outcome (PICO). By searching for articles/journals that match the keywords in PICO, namely "vinyl chloride (VC)” and "DNA methylation” online via Google Scholar and PubMed. Through this search, 74 articles/ journals were obtained. Then an assessment of the suitability of the inclusion criteria that has been determined in the title, abstract, and content is carried out full text so that 8 articles/ journals were obtained.
Results: Based on the results systematic review, picture of cause and effect relationship vinyl chloride (VC) against deoxyribonucleic acid (DNA) methylation has been found in industrial workers who inhibit deoxyribonucleic acid (DNA) methylation which ultimately causes risk of cancer and hepatocellular carcinoma (HCC).
Conclusions: There is a connection between exposure vinyl chloride (VC) and deoxyribonucleic acid (DNA) methylation that cause health hazardous effects in the form of hepatocellular carcinoma (HCC) and cancer. It's necessary to have efforts to prevent and control exposure vinyl chloride (VC), one of which is the use of Personal Protective Equipment (PPE). Results of this systematic review are very important to be used by the government as a reference in efforts to preventing and controlling chemical exposure vinyl chloride (VC) in the work environment.
Ayu, B.F., Tualeka, A.R. and Wahyudiono, Y.D.A. (2018) ‘The analysis of factors which are related to the compliance of welder workers in using workplace personal protective equipment in Pt. Pal Indonesia', Indian Journal of Public Health Research and Development, 9(5), 47–52. Available at: https://doi.org/10.5958/0976-5506.2018.00410.2.
Barsouk, Adam et al. (2021) ‘Chemical Risk Factors of Primary Liver Cancer: An Update', Hepatic Medicine: Evidence and Research, Volume 12, pp. 179–188. Available at: https://doi.org/10.2147/hmer.s278070.
Chang, L.T. et al. (2021) ‘ Hepatotoxicity caused by repeated and subchronic pulmonary exposure to low-level vinyl chloride in mice. ', Atmosphere, 12(5), 596.
Elmaci, I. et al. (2022) ‘MGMT in glial carcinogenesis. Roles from prevention to treatment.', European Journal of Cancer Prevention, 31(6), 568–576.
El-Mougy, F. et al. (2014) ‘Aberrant p16INK4A methylation: Relation to viral related chronic liver disease and hepatocellular carcinoma', South Asian Journal of Cancer, 3(1), 1–4. Available at: https://doi.org/10.4103/2278-330X.126498.
Goodman, S. et al. (2022) ‘Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review', Mutation Research/reviews in Mutation Research, 789, 108408.
Habeeb, M. and Sugumaran, A. (2022) ‘Strategies of cell signaling and critical focus on etiology of hepatocellular carcinoma', Biointerface Research in Applied Chemistry. AMG Transcend Association, 5187–5198. Available at: https://doi.org/10.33263/BRIAC124.51875198.
Khodaei, R. et al. (2019) ‘Voltammetric immunosensor for E-cadherin promoter DNA methylation using a Fe 3 O 4-citric acid nanocomposite and a screen-printed carbon electrode modified with poly (vinyl alcohol) and reduced graphene oxide', Microchimica Acta, 186, 1–12.
Liao, X. et al. (2021) ‘ A novel one-pot fluorescence tagging and depyrimidination strategy for quantification of global DNA methylation', Analytica Chimica Acta, 34036, 1239.
Luo, B. et al. (2022) ‘Covalent organic framework nanosheet anchored with highly dispersed Au nanoparticles as a novel nanoprobe for DNA methylation detection', Journal of Colloid and Interface Science, 626, 241–250.
Menezo, Y., Dale, B. and Elder, K. (2019) ‘The negative impact of the environment on methylation/epigenetic marking in gametes and embryos: A plea for action to protect the fertility of future generations', Molecular Reproduction and Development, 86(10), 1273–1282.
Nishiyama, A. et al. (2020) ‘Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation', Nature communications, 11(1), 1222.
Rafi'ah, Tualeka, A.R. and Widajati, N. (2018) ‘A correlation analysis of attitude, subjective norm and behavioral control toward the intention of safety behavior: (A study on plate cutting workers of commercial ships division PT. PAL Indonesia (Persero)', Indian Journal of Public Health Research and Development, 9(5), 137–141. Available at: https://doi.org/10.5958/0976-5506.2018.00426.6.
Rashed, W.M. et al. (2020) ‘Hepatocellular Carcinoma (HCC) in Egypt: A comprehensive overview', Journal of the Egyptian National Cancer Institute. Springer. Available at: https://doi.org/10.1186/s43046-020-0016-x.
Rattan, S. et al. (2019) ‘Prenatal and ancestral exposure to di (2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries', Toxicology and applied pharmacology, 379, 114629.
Ren, J. et al. (2019) ‘The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers', Plos one, 14(8), e0220500.
Sanaei, M., Kavoosi, F. and Modaresi, F. (no date) ‘DNA methylation of tumor suppressor genes in hepatocellular carcinoma. ', Iranian Journal of Pediatric Hematology & Oncology.
Sedgwick, B. (2004) ‘Repairing DNA-methylation damage', Nature reviews Molecular cell biology, 5(2), 148–157.
Silva, I.R. et al. (2019) ‘Evaluation of DNA methylation changes and micronuclei in workers exposed to a construction environment', International Journal of Environmental Research and Public Health, 16(6). Available at: https://doi.org/10.3390/ijerph16060902.
Sirait, F.A. et al. (2018) ‘Control of hazardous chemical as an effort for compliance criteria of OHS management system: A cross-sectional study at PT. X Surabaya, Indonesia', Indian Journal of Public Health Research and Development, 9(11), 555–559. Available at: https://doi.org/10.5958/0976-5506.2018.01515.2.
Weihrauch, M. et al. (2001) ‘Frequent k-ras-2 mutations and p16 INK4A methylation in hepatocellular carcinomas in workers exposed to vinyl chloride', British Journal of Cancer, 84(7),.982–989. Available at: https://doi.org/10.1054/bjoc.2000.1675.
Wu, F. et al. (2013) ‘Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers', International Journal of Occupational Medicine and Environmental Health, 26(1), 173–182.
Ye, W., Siwko, S. and Tsai, R.Y.L. (2021) ‘Sex and race-related dna methylation changes in hepatocellular carcinoma', International Journal of Molecular Sciences. MDPI. Available at: https://doi.org/10.3390/ijms22083820.
Yu-Lan Qiu et al. (2019) ‘Association Between Methylation of DNA Damage Response-related Genes and DNA Damage in Hepatocytes of Rats Following Subchronic Exposure to Vinyl Chloride', Chemosphere, 227, 323–328.
Zhao, X. et al. (2022) ‘Novel deoxyribonucleicacid Methylation Peturbations in Workers Exposed to Vinyl Chloride', Toxicology and Industrial Health, 07482337221098600. Available at: http://ejurnal.poltekkes-tjk.ac.id/index.php/JK.
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