Peran Insulin-like Growth Factor-1 dan Adiponektin dalam Hubungan antara Asupan, Aktifitas Fisik, dan Sindrom Metabolik pada Anak dan Remaja Melayuaustronesia: Protokol Resensi Sistematis
Unduhan
Latar Belakang: Faktor risiko sindrom metabolik berkembang di masa kanak-kanak dan berlanjut sepanjang hidup, yang dapat menyebabkan mereka berisiko lebih tinggi terkena penyakit kardiovaskular dan kematian dini. Pola makan yang sehat dan aktif secara fisik diharapkan dapat mengubah risiko sindrom metabolik (MetS). Namun, pengamatan tersebut terutama dilakukan pada sampel orang dewasa dan mekanisme biologis yang menghubungkan faktor perilaku tersebut dan MetS pada anak-anak dan remaja masih perlu dieksplorasi. Orang Asia lebih mungkin tertular MetS dibandingkan orang kulit putih, namun studi pada anak-anak Melayu-Austronesia sangat minim.
Tujuan: Penelitian ini bertujuan untuk meninjau dan menilai secara komprehensif penelitian yang menjelaskan faktor biologis (insulin-like growth factor-1 dan adiponektin) yang mungkin mengaitkan hubungan antara faktor risiko tersebut dan MetS pada anak-anak Melayu-Austronesia.
Metode: Pencarian akan dilakukan di PubMed, Scopus, Web of Science, Google Scholar, dan database lokal Garuda (Garba Rujukan Digital, Bahasa Indonesia) dan Mycite (indeks kutipan Malaysia). Semua studi kohort prospektif yang menguji hubungan salah satu faktor perilaku (asupan makanan atau aktivitas fisik) dan salah satu faktor biologis (Faktor pertumbuhan seperti insulin atau adiponektin) dengan MetS atau komponennya pada anak-anak sehat dengan paparan dimulai dari usia 1 dan 12 tahun dan hasil mulai dari 1 tahun dua bulan sampai usia 18 tahun memenuhi syarat. Hanya literatur dalam bahasa Inggris dan bahasa lokal dari awal hingga 31 Desember 2023 yang memenuhi kriteria kelayakan yang akan disertakan. National Institute of Health tool untuk studi observasional akan digunakan untuk menilai kualitas studi yang disertakan. Resensi sistematis ini sudah teregistrasi pada PROSPERO dengan nomor CRD42023471481.
Hasil: Temuan ini mungkin menjelaskan bagaimana faktor biologis yang telah ditentukan sebelumnya berkaitan dengan faktor perilaku tersebut pada MetS pada anak-anak. Temuan ini juga akan dipublikasikan dalam jurnal peer-review.
Kesimpulan: Tinjauan ini menggunakan database yang relevan untuk mengoptimalkan pencarian studi yang memenuhi syarat. Studi yang memenuhi syarat akan diambil oleh lebih (empat) peneliti yang bekerja secara independen dengan template ekstraksi data yang telah ditentukan sebelumnya. Ada kemungkinan beberapa penelitian melaporkan temuan signifikan pada protein pengikat IGF-1 dibandingkan total IGF-1 atau rasio molarnya yang akan menantang analisis statistik
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