The effect of 3% binahong leaf extract gel on the wound healing process of post tooth extraction

Olivia Avriyanti Hanafiah, Diana Sofia Hanafiah, Rahmi Syaflida

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Background: One of the common frequently performed procedures in dentistry is tooth extraction. After tooth extraction, a series of biological events occurs in the alveolar socket that ultimately results in healing of the socket. Binahong (Anredera cordifolia) is an herbaceous plant that contains active compounds that may accelerate the wound healing process. Purpose: The aim of this study is to investigate the effect of 3% binahong leaf extract gel on the healing process of the postextraction wound. Methods: 3% binahong leaf extract gel was prepared with the composition of 1 g carbopol, 1 g hydroxypropilmethylcellulose (HPMC), 4 g glycerin, 3 g triethanolamine (TEA), 0.04 g Nipagin, 0.04 g Nipasol, 1.2 g binahong leaf extract and Aq ad 40 g. A total of 18 people were subjected to tooth extraction and were then divided into two groups, with nine people in the binahong group and nine in the control group. Following that, residual socket volume (RSV) was examined on days 3, 7 and 14 after the extraction in both the binahong and control groups. The RSV value was obtained by calculating the mesiodistal x bucolingual width x the depth probing and measured using a calliper and probe. Repeated analysis of variance (ANOVA) and Friedman test followed by Wilcoxon and dependent t-test (p<0.05) were used to analyse data. Results: Significant difference in the mean RSV between the control and binahong groups was observed on days 3, 7 and 14 post tooth extraction. The RSV value in the binahong group was lower when compared to the control group (p <0.05). Conclusion: 3% binahong leaf extract gel can accelerate the process of healing socket wounds.


3% binahong extract gel; binahong; residual socket volume; socket healing; tooth extraction

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Araújo MG, Silva CO, Misawa M, Sukekava F. Alveolar socket healing: What can we learn? Periodontol 2000. 2015; 68(1): 122–34.

Pagni G, Pellegrini G, Giannobile W V., Rasperini G. Postextraction alveolar ridge preservation: biological basis and treatments. Int J Dent. 2012; 2012: 1–13.

Hupp JR, Ellis E, Tucker MR. Contemporary oral and maxillofacial surgery. 6th ed. St Louis Missouri: Mosby Elsevier; 2014. p. 703.

Khullar S, A M, Datta P. Healing of tooth extraction socket. Heal Talk. 2012; 4(5): 37–9.

de Sousa Gomes P, Daugela P, Poskevicius L, Mariano L, Fernandes MH. Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: a focused review. J oral Maxillofac Res. 2019; 10(3): e2.

Farina R, Trombelli L. Wound healing of extraction sockets. Endod Top. 2011; 25(1): 16–43.

Herrera-Briones FJ, Prados Sánchez E, Reyes Botella C, Vallecillo Capilla M. Update on the use of corticosteroids in third molar surgery: systematic review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 116(5): e342–51.

Hernández-Viana S, Silva-Gómez N, Gálvis-Pareja DA, Martínez-Pabón MC. The use of analgesics and anti-inflammatories in an oral surgery service in Medellín, Colombia, 2013-2015. Rev Fac Odontol. 2019; 30(2): 154–68.

Utami P, Puspaningtyas DE. The miracle of herbs. Jakarta: AgroMedia Pustaka; 2013. p. 38–41.

Hariana A. 262 tumbuhan obat & khasiatnya. Jakarta: Penebar Swadaya; 2013. p. 60–1.

Mutiara G, Nurdiana, Utami YW. Efektifitas hidrogel binahong (Anredera cordifolia (Ten.) Steenis) terhadap penurunan jumlah makrofag pada penyembuhan luka fase proliferasi tikus putih (Rattus norvegicus) galur Wistar kondisi hiperglikemia. Maj Kesehat FKUB. 2015; 2(1): 29–40.

Rathee P, Chaudhary H, Rathee S, Rathee D, Kumar V, Kohli K. Mechanism of action of flavonoids as anti-inflammatory agents: a review. Inflamm Allergy Drug Targets. 2009; 8(3): 229–35.

Hanafiah OA, Trimurni A, Ilyas S, Nainggolan M, Syamsudin E. Formulation and evaluation of binahong leaves extract gel on wound healing of the palatal mucosa. J Biomimetics, Biomater Biomed Eng. 2020; 48: 85–91.

Yüce E, Kömerik N. Potential effects of advanced platelet rich fibrin as a wound-healing accelerator in the management of alveolar osteitis: A randomized clinical trial. Niger J Clin Pract. 2019; 22(9): 1189–95.

Srinivas B, Das P, Rana MM, Qureshi AQ, Vaidya KC, Ahmed Raziuddin SJ. Wound healing and bone regeneration in postextraction sockets with and without platelet-rich fibrin. Ann Maxillofac Surg. 2018; 8(1): 28–34.

Faheem, Samra. Patients compliance and follow-up rate after tooth extraction. IOSR J Dent Med Sci. 2017; 16(5): 115–20.

Motamedi MHK, Navi F, Koushki ES, Rouhipour R, Jafari SM. Hemostatic tampon to reduce bleeding following tooth extraction. Iran Red Crescent Med J. 2012; 14(6): 386–8.

Mozzati M, Gallesio G, di Romana S, Bergamasco L, Pol R. Efficacy of plasma-rich growth factor in the healing of postextraction sockets in patients affected by insulin-dependent diabetes mellitus. J Oral Maxillofac Surg. 2014; 72(3): 456–62.

Hanafiah OA, Abidin T, Ilyas S, Nainggolan M, Syamsudin E. Wound healing activity of binahong (Anredera cordifolia (Ten.) Steenis) leaves extract towards NIH-3T3 fibroblast cells. J Int Dent Med Res. 2019; 12(3): 854–8.

Supriatno. Antitumor activity of Papua’s Myrmecodia pendans in human oral tongue squamous cell carcinoma cell line through induction of cyclin-dependent kinase inhibitor p27Kip1 and suppression of cyclin E. J Cancer Res Ther. 2014; 2(3): 48–53.

Hanafiah OA. Pengaruh pemberian gel ekstrak daun binahong (Anredera cordifolia (Ten.) Steenis) dan gel Aloclair® terhadap ekspresi TGFβ1 dan PDGF-BB sebagai penanda proliferasi sel fibroblas pada penyembuhan luka di mukosa palatal tikus Wistar. Dissertation. Medan: Universitas Sumatera Utara; 2019. p. 100–3.

Shah P, Keppler L, Rutkowski J. A review of platelet derived growth factor playing pivotal role in bone regeneration. J Oral Implantol. 2014; 40(3): 330–40.

Gilbert RWD, Vickaryous MK, Viloria-Petit AM. Signalling by transforming growth factor beta isoforms in wound healing and tissue regeneration. J Dev Biol. 2016; 4(2): 21.

Gurcharan Singh GK a/p, Utami NV, Usman HA. Effect of topical application of binahong [Anredera cordifolia (Ten.) Steenis] leaf paste in wound healing process in mice. Althea Med J. 2014; 1(1): 6–11.

Ardiana T, Kusuma APK, Firdausy MD. Efektivitas pemberian gel binahong (Adredera Cordifolia) 5% terhadap jumlah sel fibroblast pada soket pasca pencabutan gigi marmut (Cavia Cobaya). ODONTO Dent J. 2015; 2: 64–70.

Kumar V, Abbas AK, Aster JC. Robbins and Cotran pathologic basis of disease. 9th ed. Philadelphia: Elsevier Saunders; 2015. p. 73–91.

Ågren M. Wound healing biomaterials - volume 1: therapies and regeneration. Duxford: Elsevier; 2016. p. 7–8.

Agyare C, Dwobeng AS, Agyepong N, Boakye YD, Mensah KB, Ayande PG, Adarkwa-Yiadom M. Antimicrobial, antioxidant, and wound healing properties of Kigelia africana (Lam.) Beneth. and Strophanthus hispidus DC. Adv Pharmacol Sci. 2013; 2013: 692613.

Leliqia NPE, Sukandar EY, Fidrianny I. Antibacterial activities of Anredera Cordifolia (Ten.) V. Steenis leaf extracts and fractions. Asian J Pharm Clin Res. 2017; 10(12): 175–8.

Kim S, Lee H, Lee S, Yoon Y, Choi K-H. Antimicrobial action of oleanolic acid on Listeria monocytogenes, Enterococcus faecium, and Enterococcus faecalis. PLoS One. 2015; 10(3): e0118800.

Wang C-M, Jhan Y-L, Tsai S-J, Chou C-H. The pleiotropic antibacterial mechanisms of ursolic acid against methicillin-resistant staphylococcus aureus (MRSA). Molecules. 2016; 21(7): 884.


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