Dermatology Life Quality Index (DLQI) Score in Acne Vulgaris after Epigallocatechin-3-Gallate (EGCG) 3% as an Adjuvant of Tretinoin 0,025% Cream
Downloads
Background: Acne vulgaris (AV) often occurs at the age of puberty, most people with AV feel ashamed of their appearance. It has been believed that green tea contains high level antioxidant, such as Epigallocatechin-3-gallate (EGCG). Purpose: This study is to compare quality of life from the patient of acne vulgaris before and after using 3% Epigallocatechin-3-Gallate (EGCG) cream as adjuvant therapy of 0,025% tretinoin cream with 0,025% tretinoin cream alone in the treatment of AV. Methods: This study is a quasi-experimental study with a pre-test and post-test design, and a control group design aiming to know the difference in quality of life of 46 samples after administration of EGCG cream combined with tretinoin cream compared to the group that was given tretinoin cream alone in patients with AV for 12 weeks, and then evaluate patients satisfaction and change in quality of life after treatment using the Dermatology Life Quality Index (DLQI). Result: Statistical analysis found that there was a significant difference (p-value <0.05) in the quality-of-life value of research subjects in the treatment group when compared between the initial arrival to week 12 with a p-value of 0.000. Distribution of DLQI values in research subjects who were given 3% EGCG cream therapy as adjuvant therapy with 0.025% tretinoin cream. Conclusion: Both groups showed an improvement in the DLQI value with the interpretation of the DLQI value at week 12 being both 100%, but the treatment groups DLQI decline faster than the control groups.
Tan JKL, Bhate K. A global perspective on the epidemiology of acne. British Journal of Dermatology 2015; Jul:172 Suppl 1:3-12.
Zhang B, Choi YM, Lee J, An IS, Li L, He C, et al. Toll-like receptor 2 plays a critical role in pathogenesis of acne vulgaris. BioMed Central 2019; 2019(3(4)): 2–7.
Lynn DD, Umari T, Dunnick CA, Dellavalle RP. The epidemiology of acne vulgaris in late adolescence. Adolescent Medicine Clinics 2016; 10(190116): 13–25.
Bowe WP, Doyle AK, Crerand CE, Margolis DJ, Shalita AR. Body image disturbance in patients with acne vulgaris. American Journal Of Clinical Dermatology 2011; 4(7): 35–41.
Kelompok Studi Dermatology Kosmetik Indonesia. Panduan praktik klinis PERDOSKI. 1st ed. Jakarta: PERDOSKI; 2017. p. 248
Akyazı H, Baltacı D, Alpay K, Hocaoğlu Ç. Quality of life in adult patients with acne vulgaris before and after treatment erişkin akne vulgaris hastalarında tedavi öncesi ve sonrası hayat kalitesi. Dicle Medical Journal 2011; 38(3): 282–8.
Abad-casintahan F, Chow SKW, Goh CL, Kubba R, Miyachi Y, Noppakun N, et al. Toward evidence-based practice in acne : consensus of an asian working group. Journal Dermatology 2011; 38(910): 1041–8.
Oyetakinwhite P, Tribout H, Baron E. Protective mechanisms of green tea polyphenols in skin. Oxidative Medicine and Cellular Longevity 2012; 2012(4): 1–8.
Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting p . acnes. The Journal of investigative dermatology 2012; 133(2): 429–40.
Yoon JY, Kwon HH, Min SU, Thiboutot DM, Suh DH. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting p . acnes. The Journal of investigative dermatology 2013; 1(12): 429–40.
Berg M, Lindberg M. Possible gender differences in the quality of life and choice of therapy in acne. Journal of the European Academy of Dermatology and Venereology 2011; 969–72.
Hendra A, Pamungkas R, Ramona F, Prakoeswa S. The relationship between skin phototype, gender, and stress level with the incidence of ace vulgaris among adolescents in surakarta. Dermatology Report 2019; 11(1): 44–7.
Damayanti, Rosita C, Prsakoeswa S, Purwanto DA, Endaryanto A. Molecular docking , pharmacokinetics , and toxicity prediction of epigallocatechin-3-gallate ( egcg ) on ikk receptor in photoaging prevention. Indian Journal of Forensic Medicine and Toxicology 2020; 14(2): 1467–73.
Cong T-X, Hao D, Wen X, Li X-H, He G, Jiang X. From pathogenesis of acne vulgaris to anti-acne agents. Archives of Dermatological Research 2019; 311(5): 337–49.
Kerns M, Chien A, Kang S. Skin Aging. In: Kang. S, Amagai M, Bruckner. AL, Enk. AH, Margolis. DJ MA et al, editor. Fitzpatrick dermatology in general medicine. New york: Mc Graw Hill; 2019. p. 1779–80.
Shen W, Pan Y, Jin B, Zhang Z, You T, Qu Y. Effects of tea consumption on anthropometric parameters , metabolic indexes and hormone levels of women with polycystic ovarian syndrome : a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne) 2021; 12: 1–15.
M B, L D, G M. The process of ageing reflected by histological changes in the skin. Romanian Journal of Morphology and Embryology 2013; 54(3): 797–804.
Dai W, Ruan C, Zhang Y, Wang J, Han J, Shao Z, et al. Bioavailability enhancement of EGCG by structural modi fi cation and nano- delivery : a review. Journal of functional foods 2020; 65(12 2019): 1–9.
Fox L, Csongradi C, Aucamp M, Plessis J, Gerber M. Treatment modalities for acne. Multidisciplinary Digital Publishing Institute 2016; 21(1069): 1–20.
AK Mohiuddin. A comprehensive review of acne vulgaris. Clinical Research in Dermatology: Open Access 2019; 6(2): 1-34
Tan J, Bhate K. A global perspective on the epidemiology of acne. The British Journal of Dermatology 2014;(9): 1–21.
Tan AU, Schlosser BJ, Paller AS. International Journal of Women ’ s Dermatology Review. A review of diagnosis and treatment of acne in adult female patients . International Journal of Women's Dermatology 2018; 4(2): 56–71.
Kucharska A, Szmurło A, Sińska B. Significance of diet in treated and untreated acne vulgaris. Advances in Dermatology and Allergology 2016; 33(2): 81–6.
Ghaderi R, Saadatjoo A, Ghaderi F. Evaluating of life quality in patients with acne vulgaris using generic and specific questionnaires. Dermatology Research and Practice 2013; 25: 1–6.
Aksoy B. Which quality of life scale should be used to evaluate acne vulgaris patients ? CADI or DLQI? A prospective study. Archives of Clinical and Experimental Medicine 2019; 4(2): 90–3.
Copyright (c) 2023 Berkala Ilmu Kesehatan Kulit dan Kelamin
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
- Copyright of the article is transferred to the journal, by the knowledge of the author, whilst the moral right of the publication belongs to the author.
- The legal formal aspect of journal publication accessibility refers to Creative Commons Atribusi-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/)
- The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation
The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.
